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Biomedical subjects

Y Lanson

Publications and source records attributed to Y Lanson.

At least 55 records · Page 3Linked to original sources
PubMed1985

[Metabolic evaluation in urinary lithiasis. What is a reasonable level? 1: Theoretical approach].

Whereas the etiology of urinary calculi and their metabolic exploration should be known, it appears unreasonable to conduct exhaustive metabolic explorations in all patients, therapy being usually symptomatic and based on advice on hygiene and diet. However, etiologic diagnosis is essential in a small number of cases: those which could benefit from effective preventive and curative measures and for which morbidity is elevated: cystinuria, hyperparathyroidism, uric acid calculi, patients at high developmental risks. It is possible, by simple, low cost means to select 95% of these patients. After a theoretical study of the distribution and lithiasic etiology, a practical conduct is proposed which takes into account the cost-effective ratio.

Acidosis↗
PubMed1985

[Bladder exstrophy and pregnancy. Apropos of 2 cases].

The authors report two cases of pregnant women suffering from exstrophy of the bladder. One of the patients had been operated on in childhood for reconstruction of the bladder, and the other had undergone Coffey's operation, so that both were able to lead practically normal lives in adulthood. Three children were born by prophylactic cesarean. Exstrophy of the bladder is often associated with other urological, genital or, on occasion, orthopedic, malformations. This article analyzes the consequences of these malformations on the course of pregnancy and delivery, and the consequences of pregnancy on the urinary tract or on the different types of surgical reconstruction. The indications for the type of delivery (natural passages or cesarean section) are discussed in the light of the author's personal experience and a review of the literature.

Abortion, Spontaneous↗
PubMed1985

[Priapism through the centuries].

Priapism is known from egyptian antiquity, but greek doctors give the name of god Priape, to this pathology. The physiopathology is controversial, between Paré and the authors of Middle age tradition medical. The treatment is at first the use of quack medicines, and the Velpeau used surgery.

History, 17th Century↗
PubMed1985

[Metabolic evaluation of urinary calculi. What is a reasonable limitation? 2: Practical approach].

There appears to be little justification for conducting major metabolic screening for all cases of urinary calculi, both because of the cost, and the weak therapeutic advantages faced with the increased urine output. It is more logical to use simple methods to distinguish two groups of patients: Those in whom the affection is easily curable: dietary excess, abuse of therapeutic means, hyperparathyroidism, uric acid stones. Those in whom the affection may become worse: cystinuria, urinary malformations, recurrent calculi. Simple investigations in all patients should be: Antecedents, regimens, drugs. Radiography, analysis of stones, allowing for errors. Cystinuria, urinary pH. Creatininemia, uricemia, calcemia. Examinations must be performed effectively, even in outpatients, and the results read (not always the case). For patients at risk, discovered initially or only after this first selection, excretion anomalies are investigated, only a few of them being submitted to a Pak's test.

Humans↗
PubMed1984

Carcinoid tumor occurring in a teratoid malformation of the kidney. An immunohistochemical study.

A case of a carcinoid tumor of the kidney that was intimately related to a mixed dysplastic and teratomatous lesion is reported. This lesion displayed focal transitional, mucinous, and endocrine differentiations. Immunofluorescence studies permit the identification of three immunoreactive products: somatostatin, glucagon, and serotonin. It is suggested that the carcinoid tumor arises from this peculiar lesion, which exhibits cells of endocrine lineage.

Aged↗
PubMed1984

[Renal carcinoma with argyrophil cells].

A case of an unusual type of renal carcinoma is reported. The tumor had a poorly differentiated appearance with focal endocrine differentiation. Scattered argyrophilic cells were revealed by the Grimelius procedure. The relationship of this tumor to other neoplastic processes displaying endocrine differentiation is considered. The present case must be segregated from the classic carcinoid group. It belongs to the heterogeneous class of carcinoma with argyrophil cells and bears some resemblance to the atypical carcinoid.

Carcinoid Tumor↗
PubMed1984

[Exstrophy of the bladder and pregnancy].

Two patients with bladder extrophy who had been operated on during infancy (the one by reconstruction of the bladder and the other by Coffey's operation) had delivered by Caesarean section, in the one patient of one child and in the other of two normal children. They formed the basis of this study. Vesical extrophy or ectopia vesicae is a rare malformation (in 1/40 000 to 1/50 000 births). It occurs most often in male children. It can be associated with genital, urological and orthopaedic malformations. The principal complications that can occur in pregnancy are urinary tract infections, prematurity, malpresentations and genital prolapse. As far as the urological side is concerned the complications are of ureteric stones, metabolic troubles, stenosis or obstruction of the uretero-sigmoid anastomosis following Coffey's operation, and ileal prolapse if Bricker's operation had been undertaken. The ways in which the babies should be delivered are discussed, as are the risks of this malformation recurring in children who are born to mothers with vesical extrophy.

Adult↗
PubMed1984

[Organ donors: survey of 1000 persons].

According to the french law, organs may be removed from all persons who have not, prior to their death, notified their opposition. The survey shows that 56% had not heard of the law, although 77% were willing to donate. There were marked differences in the answers of the different social groups, the lower groups being less informed and more reserved towards the idea of organ donation. The women asked were less willing than the men to donate their own organs or those of their families, and yet they said they had given more thought to this problem. Finally, although this survey was carried out in an area where there been widespread information on the subject, 94% considered that the public were not sufficiently informed. It is true that, of the 20% against donation, only 1 in 10 knew the practical possibilities for refusal. Could we not envisage a system, as exists in other countries, whereby the acceptance or refusal is mentioned on the identity card? We know in advance that 77% would be willing to donate.

Adolescent↗
PubMed1983

Endocrine cells in the prostate gland, urothelium and Brenner tumors. Immunohistological and ultrastructural studies.

Endocrine cells are a normal constituent of the prostate gland, prostatic urethra and urinary bladder mucosa. Positive results using immunohistochemical technics were obtained only with antiserotonin antibodies. In normal tissues, there was a close similarity between the distribution of argyrophilic cells (Grimelius) and serotonin-storing cells. Some striking features were the patchy distribution of endocrine cells, the presence of slender cytoplasmic processes occasionally reaching the luminal surface and the paucity of specialized cells in bladder mucosa. It is unlikely that endocrine cells participate in conventional neoplasms of prostate and bladder. Exceptions are lobular hyperplasia, certain adeno-carcinomas of prostate and inverted papilloma of bladder. An ultrastructural study permitted the distinction of two types of endocrine cells characterized by a different morphology of their granules. Another relevant finding was the presence of serotonin-storing cells in Brenner tumors. The latter observation emphasizes the close similarity between this neoplastic epithelium and urothelium. This implies that endocrine cells may be of mesodermal derivation.

Brenner Tumor↗
PubMed1979

[Assay of "pregnancy alpha 2 glycoprotein" in the serum of prostatic cancer patients and changes during estrogen therapy].

Preliminary results are presented after measuring Pregnancy alpha 2 glycoprotein (P.A.G.) in a series of healthy males and those with cancer of the prostate, some of whom were being treated with oestrogens. Serum P.A.G. levels were measured in 21 patients with cancer of the prostate to observe any changes occurring during treatment with oestrogens. There was no significant difference between the P.A.G levels in healthy males and those with untreated prostatic cancer. Treatment however causes increased P.A.G. levels with wide individual variations. There is no apparent relationship between P.A.G. levels and the tumor stage, or efficacy of treatment. A relationship does exist however between the curves of serum P.A.G. levels in pregnant women and patients with prostatic cancer treated with oestrogens. Until proved otherwise, these measurements are of no practical value in patients with prostatic cancer, and future confirmation of these results by the study of a larger number of cases would be of value only in that they avoid other teams from repeating the same investigations.

Aged↗
PubMed1976

[Recto-sigmoid carcinoma after uretero-sigmoidostomy. One case, with a review of the literature (author's transl)].

A case of recto-sigmoid adenocarcinoma, developing 25 years after bilateral uretero-sigmo dostomy for extrophia vesicae in a 29 year old man. A study of the literature emphasises the long delay before its appearance, the gastrointestinal nature of the tumour and its grave prognosis. The pathogenesis of this lesion is unknown at present, and consideration should be given to the effects of urine on the digestive mucosa and the role of a possible inflammatory granuloma, but also the possibility of a urinary tract origin, despite the apparent histological contradiction.

Adenocarcinoma↗
PubMedDate not supplied

[Carcinoma in situ of the testis].

Carcinoma in situ (C.I.S.) of the testis is the only known precancerous lesion of germ cell tumours. The prevalence and the incidence of C.I.S. are both unknown, although predisposing factors have been identified: history of germ cell tumour of the contralateral testis, cryptorchidism or history of ectopic testis, decreased fertility or sterility. The incidence is higher in the presence of a combination of several of these factors. No complementary investigations have been demonstrated to be of any value in the detection of C.I.S. which can only be diagnosed, at the present time, by means of surgical biopsy. Once C.I.C. has developed, it never resolves spontaneously. In one half of cases the C.I.S. evolves into an invasive tumour over a period of 5 years. There is no consensus concerning the population in which testicular biopsy should be proposed looking for C.I.S. A large scale C.I.S. screening and detection programme has been proposed in Denmark. However, it is not clear that there is any major gain in testicular cancer morbidity and mortality in comparison with a surveillance programme of patients at risk. Apart from conservative follow-up, two types of treatment can be proposed: orchidectomy or external beam radiotherapy which appears to eradicate the C.I.S. while preserving endocrine function.

Carcinoma in Situ↗