Biomedical subjects

Y M Cycowicz

Publications and source records attributed to Y M Cycowicz.

13 recordsLinked to original sources

PubMed2001

Recognition and source memory for pictures in children and adults.

The present experiment investigated the developmental aspects of source compared to item memory. College students and 7-8-year-old children viewed pictures drawn in red or green during a study phase, and were asked either to remember the pictures for a subsequent recognition test, or to remember both the pictures and their associated colors for a subsequent source memory test. In the test phase, new and old pictures were presented in black. In the recognition task, participants were asked to make binary old/new recognition judgments, while in the source task, they were asked to make trinary old-green/old-red/new source judgements. Performance on all tasks improved with increasing age, but the age difference for source was much larger than that for item memory. It has been suggested that the frontal lobes play a critical role in the retrieval of source information, and that this brain region relative to the medial temporal lobes continues to develop into late adolescence. Thus, it is possible that immaturity of the frontal lobes may be causally related to the children's lower performance on the source memory task.

Adolescent↗

PubMed2001

The novelty P3: an event-related brain potential (ERP) sign of the brain's evaluation of novelty.

A review of the literature that examines event-related brain potentials (ERPs) and novelty processing reveals that the orienting response engendered by deviant or unexpected events consists of a characteristic ERP pattern, comprised sequentially of the mismatch negativity (MMN) and the novelty P3 or P3a. A wide variety of evidence suggests that the MMN reflects the detection of deviant events, whereas the P3a is associated more with the evaluation of those events for subsequent behavioral action. On the scalp, the novelty P3a is comprised of at least two aspects, one frontal the other posterior, each with different cognitive (and presumably neurologic) correlates. Intracranial ERP investigations and studies of patients with localized brain lesions (and, to some extent, fMRI data) converge with the scalp-recorded data in suggesting a widespread neural network, the different aspects of which respond differentially to stimulus and task characteristics.

Brain↗

PubMed2001

Remembering the color of objects: an ERP investigation of source memory.

Subjects studied pictures of common objects outlined in either red or green and were asked to memorize the objects and their associated colors. Event-related potentials (ERPs) were recorded during subsequent inclusion (i.e. item) and exclusion (i.e. source) memory tasks. The main goal of the experiment was to determine if brain signatures for familiarity and recollection, two behavioral processes thought to account for episodic memory performance, would be observed in the pattern of ERP results. For correctly recognized items, early, posterior old/new effects were recorded (approximately 300--600 ms) that did not differ in magnitude or scalp distribution between item and source memory tasks. A subsequent long-duration occipitally focused negativity (approximately 800 ms peak) was evident in the source but not the item memory task. The ERPs associated with 'source errors' in the source memory task also showed robust early old/new effects. However, 'source error' ERPs lacked frontal scalp activity compared to those associated with correct source attribution. The data suggest that a recollective response may require frontal involvement whereas a decision based on familiarity may not.

Adult↗

PubMed2000

Memory development and event-related brain potentials in children.

This review examines the evidence for the maturation of memory function during childhood using event-related brain potentials (ERP), and behavioral measures. It has been shown that brain structures implicated in different forms of memory mature during the first and into the second decade of life. Whereas the maturation rates of implicit and explicit memory have not been directly assessed in the literature, studies of the maturation of the corresponding brain regions imply that there should be a progression in the maturation of the different forms of memory. This review also motivates the use of brain imaging techniques for investigation of memory systems during the developing years. Although, only a handful of such studies with children are currently available, they demonstrate that such techniques can provide information that may be unavailable otherwise. For example, when children fail to generate the ERP old/new effect, an index of episodic retrieval, it has been suggested that they may lack the necessary pre-existing representations in their long-term lexical or semantic memories. Similarly, age-related differences in ERP scalp topography during source memory paradigms suggest that children, who do not appear to show frontal scalp activity, lack inputs from frontal regions that are necessary for successful retrieval of source information. Future research with children will reveal more details about the nature of mnemonic processing during the developmental years.

Adolescent↗

PubMed2000

A developmental trajectory in implicit memory is revealed by picture fragment completion.

Dissociations between performance on implicit and explicit tasks have often been taken as evidence that different neural structures subserve the two types of memory. One such dissociation involves developmental differences that emerge in explicit tasks, but which appear to be absent in implicit tasks. Such findings are consistent with the idea that implicit memory is subserved by a more primitive system that evolves earlier at both phylogenetic and ontogenetic levels. The present paper reviews previous studies that claimed to find evidence that implicit memory is fully developed in very young children. Issues of measurement error, ceiling effects, and insufficient power brought up questions about those studies with respect to the developmental issue. The present study compares performance on implicit (picture fragment completion) and explicit (free recall and recognition) memory tasks with groups ranging in age from 5-28 years. We find a reliable developmental trend in both implicit and explicit performance in which the former cannot be attributed to the operation of explicit memory processes. Thus, we conclude that implicit memory, like explicit memory, develops with age.

Adolescent↗

PubMed1999

ERP recordings during a picture fragment completion task: effects of memory instructions.

Sequential implicit (picture fragment completion) and explicit (free recall and recognition) memory tasks were performed by two groups of young adults. Subjects assigned to the intentional condition were asked to memorize the stimuli presented during the picture fragment completion task, whereas subjects assigned to the incidental condition were not so instructed. In the picture fragment completion task, all subjects showed savings (priming), i.e., their identification thresholds for previously seen fragments were lower than those for fragments not previously seen, and no between-group performance difference was found. Free recall performance was better for the intentional than the incidental group, but recognition performance did not differ between the groups. Despite similar between-group performance, event-related brain potentials (ERPs) recorded during the picture fragment completion and recognition tasks revealed between-group differences in information processing. The ERP data suggest that similar behavioral performance during memory tasks may have been associated with distinct neuronal mechanisms subserving priming and recollection.

Adult↗

PubMed1999

The effect of intention to learn novel, environmental sounds on the novelty P3 and old/new recognition memory.

Brain electrical activity was recorded while 32 young adults listened to frequent tones, infrequent target tones, and infrequent novel environmental sounds (some of which repeated). Subjects in the incidental group were not informed about the novel sounds, while subjects in the intentional group were informed and, in addition, were asked to memorize them for a subsequent memory test. Following the novelty oddball task, all subjects were given an old/new sound recognition memory task. The novelty P3 showed a more anterior scalp distribution and an effect of repetition in the incidental compared to the intentional group, suggesting that pre-categorizing the novel sounds influenced how they were processed. For the intentional group only, a subsequent memory effect was elicited by novel sounds that were subsequently recognized compared to those that were not, although both groups showed robust old/new ERP effects during the recognition task. The robust subsequent memory effects in the intentional group were associated with greater recognition accuracy of familiar environmental sounds relative to the incidental group. These data suggest that the encoding activity reflected in the ERP subsequent memory effect may have engendered an advantage in subsequent recognition memory performance.

Acoustic Stimulation↗

PubMed1998

Effect of sound familiarity on the event-related potentials elicited by novel environmental sounds.

The effect of sound familiarity was examined within the context of an event-related potential (ERP) novelty oddball paradigm. Brain electrical activity was recorded while subjects (16 young adults) listened to frequent tones, infrequent target tones, and infrequent novel environmental sounds. Subjects were instructed to press a button in response to the target tones only. There were 48 different novel sounds, 32 of which were repeated, and about two-thirds of which represented familiar sound concepts. The novel sounds elicited two ERP components, the novelty P3 and the P32. The novelty P3 was modulated by both repetition and familiarity, such that repeated familiar sounds elicited decreased novelty P3 amplitude at frontal sites, while repeated unfamiliar sounds elicited increased novelty P3 amplitude at posterior sites. This differential effect may reflect the operation of a neural network that distinguishes among different degrees of novelty.

Adult↗

PubMed1998

Effects of aging on the novelty P3 during attend and ignore oddball tasks.

The effects of attention were assessed on novelty P3 amplitude and scalp distribution elicited by environmental sounds in young and elderly volunteers who participated in either actively attended or ignored oddball conditions. For the young, novelty P3 amplitude decreased with time on task during both attend and ignore sequences. Amplitude decrements were greatest at frontal sites during the attend condition, but at all sites during the ignore condition. A reliable amplitude decrement was not observed for the elderly in either the attend or ignore oddball series. The data suggest that attention differentially activates multiple generators that contribute to scalp-recorded novelty P3 activity. The lack of novelty P3 habituation seen in the elderly is consistent with changes in frontal lobe function as age increases.

Acoustic Stimulation↗

PubMed1997

Picture naming by young children: norms for name agreement, familiarity, and visual complexity.

Researchers concerned with the development of cognitive functions are in need of standardized material that can be used with both adults and children. The present article provides normative measures for 400 line drawings viewed by 5- and 6-year-old children. The three variables obtained-name agreement, familiarity, and visual complexity-are important because of their potential effect on memory and other cognitive processes. The normative data collected in the present study indicate that young children are different from adults in both the name most frequently assigned and the number of alternative names provided. The alternative names given by the children are either coordinate names or names of objects that are visually similar to the pictured object. In addition, the failure (to name) rate is higher among young children compared to adults. Thus, we conclude that unequivocal interpretation of age-related differences in cognitive functions can be made only when age-appropriate pictorial stimuli are chosen.

Adult↗

PubMed1997

A developmental study of the effect of temporal order on the ERPs elicited by novel environmental sounds.

Event-related brain potentials (ERPs) were recorded from 16 subjects in each of the following age groups, 5-7, 9-11, 14-16, and 20-28 years of age. Subjects performed a novelty oddball task, in which frequent, standard tones (80% probability) were intermixed with infrequent tones to which the subject responded (10%), along with 48 unique novel, environmental sounds (10%). Analyses focused on the effects of temporal order (either serial order within the block or block number) in interaction with age group on the ERPs to the novel sounds. The amplitude and scalp distribution of two ERP components were analyzed, the 'novelty P3,' assumed to reflect aspects of the orienting response, and the P32, a component that may be synonymous with the P3b. Evidence suggests that the frontal aspect of the scalp distribution of the novelty P3 depends upon the integrity of the prefrontal cortex. Temporal order produced systematic (primarily linear) reductions in novelty P3 amplitude that were greater at frontal than posterior electrode sites. The P3(2) did not show consistent effects of temporal order. Both of these phenomena were highly similar for all four age groups. It is concluded that the brain's response to novelty is similar across a wide age range, involving a neural circuit with both frontal and posterior elements.

Acoustic Stimulation↗

PubMed1996

Naming norms for brief environmental sounds: effects of age and dementia.

Brief nontonal sounds are used in electrophysiology in the novelty oddball paradigm. These sounds vary in the brain activity they elicit and in the degree to which they can be identified, named, and remembered. Because ease of sound identification may influence sound processing, naming and conceptual norms were determined for 100 sounds for 77 young adults (Experiment 1). Naming ability decreases in normal and pathological aging. Therefore, norms were also derived for older adults (Experiment 2) and for probable Alzheimer's disease patients (Experiment 3). With respect to the young adults, perseverative naming behavior increased in these groups, and sound and picture naming performance were correlated. In Experiment 4, the sound-naming performance of children aged 5-6, 9-11, and 14-16 years was compared. Name and conceptual agreements improved with age, whereas perseverative behavior decreased. These normative data should be useful in guiding sound selection in future studies and help clarify the relationships between sound naming and other variables, including direct and indirect memory performance.

Acoustic Stimulation↗

PubMed1996

An ERP developmental study of repetition priming by auditory novel stimuli.

Event-related potentials were recorded from participants 5-7, 9-11, 14-16, and 22-28 years old during an auditory novelty oddball task. In this task, stimuli about which the participant is not instructed (i.e., novel or uncategorized) typically elicit a more frontally oriented P3 scalp topography (novelty P3). In contrast, stimuli to which the participant must respond (i.e., target or precategorized) elicit a P3 with a more posterior scalp topography. Repetition of identical novel stimuli led to a similar reduction in novelty P3 amplitude for all age groups. Moreover, with repetition the shift in scalp topography of the novelty P3 to a more parietally oriented distribution was similar in children and adults. A second component, the P3(2) (assumed to be an analog of the P3b), exhibited a repetition priming effect in both the adults and the youngest children. The fact that age-related differences induced by novel repetition were small and not systematic indicates that the processing of novel information is similar across a wide age range.

Acoustic Stimulation↗