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Biomedical subjects

Y M Fakunle

Publications and source records attributed to Y M Fakunle.

30 records · Page 2Linked to original sources
PubMed1978

Cryoglobulinaemia and circulating immune complexes in tropical splenomegaly syndrome.

Large amounts of cryoglobulins and soluble immune complexes were detected in the sera of thirteen patients with tropical spenomegaly syndrome (TSS). Complexes were detected by three different methods: radiobioassay, a modified rheumatoid factor-binding activity method and a modified Clq-binding assay. Protein precipitable by 4% polyethylene glycol (PEG) was also measured. The cryoglobulins contained IgM, IgG and in some cases, C3. It is likely that in TSS, marked immune complex formation is associated with hypergammaglobulinaemia and that continuous engulfment of these complexes by cells of the reticuloendothelial system (RES) is the cause of the hepatosplenomegaly.

Antigen-Antibody Complex↗
PubMed1978

Diarrhoea, constipation and intestinal transit in a northern Nigerian population.

Healthy Nigerians from Zaria have a short intestinal transit time. It is usual for them to open their bowels daily and their concept of diarrhoea and constipation differs widely from the standard medical definition. To avoid confusion care must be taken to inquire exactly what patients mean when they present with these symptoms.

Constipation↗
PubMed1977

Primary liver cell carcinoma (PLCC) in the Northern Guinea Savanna of Nigeria.

There is a high prevalence of primary liver cell carcinoma in the Guinea Savanna country of Nigeria, one of the highest frequencies in the world. The highest frequency of the tumour was among males aged 20 to 49 years. The clinical and laboratory findings are similar to those found in other series in Africa. Alpha1-foeto-protein occurred in 85% of cases while HBsAg was noted in 49% of cases.

Adolescent↗
PubMed1977

Low molecular weight (7S) IgM and free light chains in the sera of patients with the tropical splenomegaly syndrome.

The presence of naturally occurring LMW (7S) IgM was suspected on Sephadex G-200 filtration of a serum pool from patients with tropical splenomegaly syndrome (TSS). It was found in nineteen out of thirty-one sera from these patients using a polyacrylamide/agarose gel-diffusion method, and in fifteen of the sera after precipitation of the 19S IgM with 10% polyethylene glycol (PEG). Free K-light chains was detected in twenty-five out of thirty-one sera from patients with the TSS while free lambda-light chains was detected in four. The presence of 7S IgM and free light chains in sera of these patients is in keeping with our hypothesis that there is a disorder of control of immunoglobulin production in the tropical splenomegaly syndrome.

Chromatography, Gel↗
PubMed1976

A suppressor T-cell defect in tropical splenomegaly syndrome.

Serum-IgM is always abnormally high in tropical splenomegaly syndrome. It is postulated that patients with this disease have an abnormal immunoglobulin response to malaria because they lack effective T suppressor cells. This defect may be genetically determined, thus explaining the tribal and familial aggregation of the disease. Hypermacroglobulinaemia is associated with the formation of large amounts of high-molecular-weight immune complexes. These complexes are important in the pathogenesis of the clinical features of the syndrome.

Antibody Formation↗
PubMed1976

Metabolism of IgM in the tropical splenomegaly syndrome.

IgM metabolism was studied in five patients with the tropical splenomegaly syndrome and in five controls. The half-life and turnover time of I125 IgM was similar in the two groups. We conclude that the raised serum IgM levels found in patients with the tropical splenomegaly syndrome are not due to decreased IgM catabolism but are due to increased IgM production.

Humans↗
PubMedDate not supplied

Upper gastrointestinal endoscopy in Zaria, northern Nigeria.

The indications for and findings in 431 consecutive patients who had upper gastrointestinal endoscopy in Zaria from June 1978 to August 1982 are reviewed. The major indications were dyspepsia (78.1%), upper gastro-intestinal bleeding (12.1%) and portal hypertension (4.2%). Other indications were persistent vomiting, dysphagia and abdominal masses. The mean age of the patients was 32 years. The male: female ratio (3:1) was not different from that in the hospital population. There were no abnormal findings in 32.7%. 26.6% had duodenal ulcers. Duodenitis was noted in 24.8%, oesophageal varices in 6.3%, gastritis in 6.3% and hiatus hernia in 4.6%. In those who presented with upper-gastrointestinal haemorrhage, oesophageal varices (34.6%) and peptic ulcer (17.3%) were the commonest findings. Complication seen commonly were soreness in the throat and thrombophlebitis at the site of valium injection. One death was recorded from the procedure over the period.

Adolescent↗
PubMedDate not supplied

Chronic duodenitis in Zaria, northern Nigeria.

Thirty-four consecutive patients presenting to the Endoscopy clinic of the Ahmadu Bello University Teaching Hospital, Zaria with symptoms of upper abdominal pain were investigated for chronic duodenitis by endoscopy and histology and for associated diseases. Twenty-two patients had histological evidence of chronic duodenitis. No clinical features separated these from those who had no duodenitis. Endoscopy was a good enough tool for diagnosis. Stool parasites were significantly commoner in those with histological duodenitis. Gastritis was also commoner in those with duodenitis. Ranitidine appeared superior to polycrol in relieving symptoms. Endoscopy is useful in the diagnosis of severe duodenitis. Specific ulcer healing drugs may be tried in treating symptoms associated with duodenitis, though their effectiveness is still open to further research.

Antacids↗