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Biomedical subjects

Y M Gao

Publications and source records attributed to Y M Gao.

8 recordsLinked to original sources
PubMed1992

Increase in plasma thrombomodulin and decrease in plasma von Willebrand factor after regular radiotherapy of patients with cancer.

In this study, we investigated plasma levels of thrombomodulin (TM) and von Willebrand factor (vWF) in 51 patients suffering from cancer or tumor undergoing 60 cobalt radiotherapy. Plasma TM and vWF antigen were measured by immunoradiometric assay and ELISA, respectively. During radiotherapy, an increase in plasma TM in patients was observed, which was radiation-dose dependent and there was a positive correlation between plasma TM level and radiation doses. However, the level of plasma vWF in the patients was decreased during radiotherapy and there was an inverse correlation between the amount of plasma vWF and radiation doses. Our data indicate that plasma TM is an useful molecular marker for early detection of radiation injury to endothelial cells in patients undergoing radiotherapy.

Adolescent↗
PubMed1992

[Flow cytometric analysis of the garlic oil effect on DNA content of cancer cell cycle].

Flow cytometry (FCM) is a new technique developed in the recent decade. This technique may measure DNA content of 5000 cells per second and trace the dynamic changes in cell proliferation cycle and offer a hint for designing clinical treatment protocol, monitor prognosis and elucidate the mechanisms of antitumor drugs. The authors previous studies showed significant effect of garlic oil on prolongation of life expectancy and inhibition of tumor growth in mice. Using FCM the authors analysed the effect of garlic oil on cell cycle in S180 tumor cells, 2-6 hrs after single administration or multiple administration the cell number in S phase rapidly decreased, in G1 phase increased. This suggests garlic oil may blockade cells to progress from G1 phase to S phase and result in accumulation of cells in G1 phase and directly inhibit the synthesis of DNA and the cell cycle. Theoretical basis for clinical application was offered and some aspects of antitumor mechanism of garlic oil were elucidated.

Allyl Compounds↗
PubMed1989

Hepatic resection under the guidance of B-mode ultrasonography.

From Dec. 1987 to June 1988, we performed hepatic resection on 8 cases of primary liver cancer and 10 cases of benign liver tumor under the guidance of B-mode ultrasound. Of 18 cases, 2 received right hemihepatectomy, 5 underwent left hemihepatectomy or left lateral lobectomy, 9 had segmentectomy and 2 were treated by tumor removal. There was no operative death. Postoperatively, pleural effusion occurred in 3 cases and biliary fistula in 2 cases. The hospitalization time was 14-52 days with a mean of 29 days. Our results showed that the intraoperative B-mode ultrasound could not only demonstrate the number, size and boundary of lesions but also exhibit the location and orientation of the intrahepatic conduit system and its 3-dimensional relation with the lesions. It is very helpful in dealing with the intrahepatic vessels and ducts.

Adult↗
PubMed1985

Morphological and functional investigations on macrophages with heterogeneous fluorescent staining.

Four heterogeneous colors of fluorescence were demonstrated in macrophages from rabbit lymph nodes and mouse peritoneal exudate using fluorescent staining. They were bright blue, light blue, bluish green and yellow colors of fluorescence respectively. All of these 4 types of macrophages with heterogeneous colors of fluorescence could form EA or EAC rosettes and were able to phagocytose chicken erythrocytes and ink carbon granules. Among them the macrophages with bright blue color of fluorescence could form large EA or EAC rosettes and showed more rapid and stronger activity to phagocytose chicken erythrocytes, while those with bluish green and yellow colors of fluorescence showed stronger activity to phagocytose ink carbon granules.

Animals↗