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Y M Lu

Publications and source records attributed to Y M Lu.

45 records · Page 3Linked to original sources
PubMed1991

Effects of l-daurisoline on quinolinic acid-induced Ca2+ influx in hippocampus neurons in freely moving rats.

In freely moving rats, hippocampus neuronal extracellular calcium concentration (Ca2+)e and seizures were investigated. Application of quinolinic acid 156 nmol (exciting N-methyl-D-aspartate receptor, NMDA) to dorsal hippocampus elicited a decrease in (Ca2+)e by 48 +/- 5% in the infusion area and produced a characteristic abnormal EEG. l-Daurisoline dramatically prevented the reduction in (Ca2+)e, but not seizures (EEG). The results suggest that NMDA-operated calcium channels, but not NMDA-receptors, are involved in the effects of l-daurisoline on Ca2+ influx observed.

Alkaloids↗
PubMed1991

Inhibitory effect of 0,0-bisacetyldaurisoline on Ca2+ influx into synaptosomes.

The inhibitory effects of 0,0-bisacetyldaurisoline (BDSL) on 45Ca2+ uptake and [3H]GABA release from synaptosomes were investigated. BDSL (1-100 mumol.L-1) produced a concentration-related inhibition of high K(+)-stimulated 45Ca2+ uptake and [3H]GABA release (IC50 = 5.6 +/- 0.7 and 31.4 +/- 2.3 mumol.L-1, respectively) in synaptosomes but verapamil (Ver) was only weakly active. Neither BDSL (100 mumol.L-1) nor Ver (100 mumol.L-1) modified 45Ca2+ uptake in control medium (K+ 5 mmol.L-1 resting uptake) and [3H]GABA release in Ca(2+)-free medium (K+ 45 mmol.L-1 basal release). The results suggest that BDSL may be a potent Ca2+ channel blocker in neurons.

Alkaloids↗
PubMed1991

[A survey on eight patients and one family history of Peutz-Jeghers syndrome].

Eight patients with Peutz-Jeghers Syndrome (PJS) have been diagnosed by fiber light colonoscope in recent ten years in our hospital. Four of them coming from the same family. It was called "Gao family". We made a survey on 42 members in 5 generation of the family including 13 definite patients and 3 suspicious patients. The specification of PJS, the malignant change of polyps and the misdiagnosis of hamartoma are discussed in this paper.

Adolescent↗
PubMed1990

The effects of (-)-daurisoline on Ca2+ influx in presynaptic nerve terminals.

1. The effects of (-)-daurisoline on 45Ca2+ uptake and [3H]-gamma-aminobutyric acid ([3H]-GABA) release from synaptosomes of rat cerebral cortex and on contractile activity of rat aorta were examined. 2. Application of (-)-daurisoline (1-100 microM) produced concentration-related inhibition of high K(+)-stimulated 45Ca2+ uptake and [3H]-GABA release (IC50 = 7.7 +/- 0.9 microM and 10.0 +/- 1.5 microM, respectively) in synaptosomes but verapamil was only weakly active. 3. Neither (-)-daurisoline (100 microM) nor verapamil (100 microM) modified 45Ca2+ uptake in control medium (5 mM K+, resting uptake) and [3H]-GABA release in Ca-free medium (45 mM K+ basal release). 4. High K+ and noradrenaline-evoked contractions of rat aorta were inhibited by both (-)-daurisoline and verapamil. 5. In conclusion, (-)-daurisoline, which differed from verapamil in its mode of blocking Ca2+ influx may be a potent Ca2+ antagonist of Ca2+ channels in neurones.

Alkaloids↗
PubMed1990

[Clinical effect of China-made amrinone in the treatment of refractory congestive heart failure].

Clinical and hemodynamic studies were carried out in 20 patients suffering from refractory congestive heart failure with invasive technique and non-invasive methods such as tolerance exercise test, 24-hour Holter monitoring, etc. Digitalis was then withdrawn and China-made amrinone (AMR) was administered orally for 15 days. All the indices mentioned above were repeated and each patient served as his own control. The results indicate that AMR can improve hemodynamic parameters as well as exercise tolerance. Holter monitoring revealed no significant increase in arrythmogenic potentiality. The total clinical effective rate was 95%. No severe side effects were found except thrombocytopenia observed in 20% of the patients. It is suggested that China-made AMR is effective in treating refractory congestive heart failure.

Adult↗
PubMed1989

Müllerian adenosarcoma of uterus--a case report.

A rare case of Müllerian adenosarcoma occurred in the uterine endometrium of a 40-year-old woman. Histologically, the tumor was composed of an admixture of benign-appearing glands and a sarcomatous stroma. This neoplasm appears to have a relatively low malignant potential in contrast to the more aggressive form of malignant mixed Müllerian tumor. Our case was treated with hysterectomy and radiation. She was well after two and a half years.

Adult↗