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Biomedical subjects

Y M Traub

Publications and source records attributed to Y M Traub.

34 records · Page 2Linked to original sources
PubMed1981

Complications of antihypertensive therapy.

Effective use of modern antihypertensive agents requires an intimate understanding of the various side effects associated with each of the drugs. Some of the undesirable side effects are unavoidable because they are inherent in the action of the drug. For example, hypokalemia and hyperuricemia are inherent side effects of diuretic therapy. Other adverse reactions are idiosyncratic and difficult to predict. With careful monitoring and individual therapeutic planning, these side effects need not inhibit efforts to control hypertension.

Antihypertensive Agents↗
PubMed1980

Renal artery occlusion and malignant hypertension in polycystic kidney disease.

A patient with polycystic kidneys is presented, in whom obliteration of a renal artery led to the development of high renin malignant hypertension. During chronic hemodialysis 3 years later the patient had normal renin values and the blood pressure became volume-dependent. It is concluded that the occurrence of malignant hypertension and/or elevated renin values in patients with polycystic kidney disease should lead to the search for a coexisting renal artery stenosis or occlusion.

Humans↗
PubMed1980

Elevation of serum potassium during beta blockade: absence of relationship to the renin-aldosterone system.

Eighteen patients with essential hypertension were treated in a single-blind, crossover study with pindolol and with propranolol. The two drugs were compared because of known differences between them on renin secretion. We noted that plasma renin activity and plasma aldosterone concentration were suppressed by propranolol but not by pindolol. Blood pressure was reduced about equally by both drugs. Serum potassium levels rose in 17 patients on pindolol (p < 0.001) and in 14 patients on propranolol (p = 0.08). Our data suggest that serum potassium elevations induced by beta blockade do not depend on the renin-angiotensin-aldosterone system. Alternative possibilities are discussed.

Adrenergic beta-Antagonists↗
PubMed1979

Hazards in treatment of systolic hypertension.

Eight patients with arteriosclerotic systolic hypertension whose blood pressure had been nonresponsive to conventional antihypertensive therapy, were given minoxidil in daily doses of 4 to 15 mg. Within 2 to 5 days the blood pressure of seven patients was brought to more "normal" levels. After 10 to 20 days of treatment, a significant weight increase was observed with a concomitant rise of blood pressure, which could be overcome by more vigorous diuretic therapy. However, six of the seven blood pressure responders and the one nonresponder complained of severe adverse effects curtailing further use of the drug. It is concluded that despite the effectiveness of arteriolar vasodilation in the reduction of elevated systolic blood pressure, such lowering may be deleterious in patients with atherosclerotic involvement of vital organs.

Aged↗
PubMed1977

Once-a-day pindolol in hypertension.

The possibility of using pindolol on a once-a-day schedule was investigated in the treatment of mild to moderate hypertension. Eighteen patients whose blood pressure responded satisfactorily to thrice-daily administration has a similar response to the single daily dose (p greater than 0.05). The advantages of once-daily pindolol therapy as well as some of the biochemical changes produced by the drug are commented upon.

Adult↗
PubMed1976

Stimulation of renin secretion by various methods: optional results with hydrochlorothiazide.

Serum renin concentration (SRC) was determined in 97 hypertensive patients under basal conditions and during stimulation of renin secretion. Renin secretion was stimulated by upright posture and by either of the following means: (a) diet containing 20 mEq Na/24 hours for 3 days; (b) 300 mg i.v. diazoxide injections; (c) oral ingestion of 80 mg furosemide; (d) oral hydrochlorothiazide (HCT), 25 mg twice daily for 3 days. HCT was used in 6 patients previously treated with daizoxide and in 8 patients previously treated with furosemide. Using pairs of basal and stimulated SRC determinations, the patients could be classified as high, normal, or low renin hypertensives. HCT proved to be the most convenient stimulus as far as efficacy, reliability and the patients' tolerance were concerned, and compared well with sodium restriction.

Adult↗
PubMed1976

Endometriosis mimicking ureterolithiasis.

A case of endometriosis obstructing the right ureter is described, with a clinical picture mimicking ureterolithiasis. The usefulness of rapid sequence camera-scintigram in the early diagnosis of ureteral obstruction is discussed.

Adult↗
PubMed1975

Treatment of severe hypertension with minoxidil.

Minoxidil in daily doses of 6 to 40 mg was administered to 11 patients with severe hypertension. Two patients died of causes unrelated to the drug and one patient withdrew from the study. Blood pressure was controlled in the remaining eight subjects, who received the drug for periods ranging from 5 to 40 months. In three patients minoxidil could subsequently be replaced by conventional antihypertensive therapy. Adverse effects of minoxidil included fluid retention (as assessed by edema and plasma volume studies), nonspecific ECG changes, hypertrichosis and conjunctival redness. Concomitant administration of diuretic and beta-adrenergic blocking agents resulted in excellent tolerance of the treatment and high patient compliance.

Adrenergic beta-Antagonists↗