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Biomedical subjects

Y Mallet

Publications and source records attributed to Y Mallet.

4 recordsLinked to original sources
PubMed2003

Aggressiveness and quantification of epithelial proliferation of middle ear cholesteatoma by MIB1.

OBJECTIVE: To assess an easy method that predicts cholesteatoma aggressiveness. STUDY DESIGN: An experimental prospective study. METHODS: Monoclonal antibody MIB1 was used to determine epithelium proliferation in 91 cholesteatomatous ears. Clinical and surgical parameters were compared with proliferation activity to determine pathological and clinical correlation. RESULTS: Statistical correlations were established between hyperproliferation of the cholesteatoma and severe bone erosion (leading to major cholesteatoma complications) and between hyperproliferation and middle ear inflammation (associated with more surgical difficulties and a higher risk of recurrence). A high proliferation index was also found in children's cholesteatoma, which is known to have more aggressive behavior. CONCLUSION: Immunohistochemical use of the MIB1 antibody is a simple technique that can help to determine the aggressiveness of a cholesteatoma.

Adolescent↗
PubMed2003

[Radiological and surgical classification of head and neck lymph node anatomy].

OBJECTIVE: The purpose of this review is to present a systematic description of cervical lymph drainage by nodal level. MATERIAL AND METHODS: We present, in French, the radiological and surgical classification of the cervical lymph nodes with numerous illustrations. A critical analysis of the advantages and limitations of this tool is presented together with practical guidelines. RESULTS: This classification system is a useful tool for the evaluation of cervical metastases. It provides for more precise treatment and better understanding and communication between specialists, offering the standardization necessary for comparing results obtained by different teams and for multicenter studies. CONCLUSION: This classification of cervical lymph nodes by level is a useful tool for the management of cervical node involvement in head and neck cancer.

Humans↗
PubMed2001

Near total laryngectomy with epiglottic reconstruction. our experience of 65 cases.

From 1980 to 1998, 65 patients whose glottic lesions were classified T1 or T2 were operated with a reconstructive anterior frontal laryngectomy with epiglottoplasty such as described by Tucker (Arch Otolaryngol Head Neck Surg 115:1341-1344). This procedure consists of resection of the two vocal cords, in some cases one arytenoid, the anterior commissure with a part of the thyroid cartilage, the anterior part of both false vocal cords, and of 1 cm of the subglottis. The epiglottis is grasped downward to close the larynx. There were no per or postoperative deaths. Our functional results confirm those reported in the previous publications. The mean time of removal of the nasogastric tube was about 12 days and the patients were generally satisfied about their residual voice. Decannulation was performed after satisfactory peroral feeding, generally about 2 weeks postoperatively. Three patients only required subsequent procedures which can be considered due to functional failures. There were four recurrences, which means a 5-year actuarial local control rate of 94%. This operation takes place as part of our surgical treatment policy of laryngeal carcinomas, considering that this surgery is like an extensive frontolateral laryngectomy. In case of an infiltrating tumor or in case of invasion to the arytenoid cartilage, we perform a supracricoid partial laryngectomy with crico-hyoido-epiglottopexy (the Majer-Piquet's procedure).

Adult↗