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Y Marmary

Publications and source records attributed to Y Marmary.

At least 37 records · Page 2Linked to original sources
PubMed1994

Effect of interleukin-2 on salivary gland morphology and function in mice.

C57BL mice were injected intraperitoneally with 300,000 Cetus units/day of human recombinant interleukin-2 (rIL-2) for 2, 4, and 5 days to study its effect on salivary gland function and morphology. The pilocarpine-stimulated parotid salivary flow was collected via cannulation of the glandular duct. Total salivary protein was assayed spectrophotometrically, salivary electrolytes were determined by atomic absorption, and glandular lymphoid cell infiltration was evaluated histologically. After 5 days of rIL-2 administration salivary output and total salivary protein concentrations were reduced significantly. Similar changes, albeit to a lesser extent, were observed following 2 and 4 days of rIL-2 treatment. Increased lymphoid infiltration of the salivary glands was observed, and was directly related to the duration of rIL-2 administration. The effect of the lymphokine on the parotid gland gradually dwindled after cessation of treatment: 4 days posttreatment this salivary gland showed signs of recovery, which at 10 days proved to be complete. The possible use of this animal model in the study of lymphocyte-induced salivary gland diseases is discussed.

Animals↗
PubMed1992

Oral changes in interleukin-2 treated patients: a preliminary report.

Immunotherapy with high doses of interleukin-2 (IL-2) in patients with metastatic cancer is accompanied by multiorgan side effects. To determine the effect of this treatment on oral tissues, 5 cancer patients receiving a course of recombinant IL-2 (rIL-2) were followed. Oral pathology and subjective oral complaints were noted. Whole saliva parameters and routine blood and urine values were recorded daily before, during and after treatment. Mucositis and diminution of salivary flow occurred in all patients. Concomitantly, salivary sodium and protein were elevated.

Adult↗
PubMed1991

The value of arthrography in the decision-making process regarding surgery for internal derangement of the temporomandibular joint.

In this study, the clinical and arthrographic findings from 43 internally deranged temporomandibular joints (TMJs) were compared with the intra-surgical observations. In 40 of 43 joints, arthrography did not provide any additional information useful for diagnosis or treatment. In six joints, the problem was misdiagnosed. Only in three joints did arthrography demonstrate the existence of perforation in the posterior attachment that had not been suspected during the clinical examination. Because of the doubtful importance of arthrographic information for the decision-making process, it is suggested that the method be applied only in cases in which clinical examination and plain radiographs have failed to uncover the signs and symptoms indicative of a TMJ disorder.

Adolescent↗
PubMed1990

The use of monoclonal anti-CEA antibody immunohistochemistry in detecting the origin of oral cavity metastasis.

A 75-year-old woman presented with a painless swelling in the right mandibular retromolar area and numbness of the left lower lip. Radiographic examination of the mandible demonstrated an osteolytic lesion of the ascending ramus. Biopsy revealed adenocarcinoma of obscure origin. Staining of the specimen with a monoclonal antibody specific to colon carcinoma revealed its origin. On subsequent examinations, a primary tumor in the rectosigmoid region with extensive lung, liver and skeletal metastases were diagnosed. This unusual case of colonorectal carcinoma, presenting as a metastatic lesion of the mandible, was readily diagnosed by a novel immunohistochemical technique that utilizes highly specific monoclonal antibodies.

Adenocarcinoma↗
PubMed1989

Beta-adrenergic responsiveness in a human submandibular tumor cell line (A253).

Salivary epithelial functions are regulated by the autonomic nervous system. In this regard, we have been studying the morphology and neuroreceptor composition of A253, an immortal cell line isolated from a human submandibular carcinoma (Giard et al., JNCI, 51:1417-1421, 1973). Phase contrast and electron microscopic observations indicate that A253 cells are of epithelial origin. Physiologically, A253 cells possess beta-adrenergic, but not alpha-adrenergic or muscarinic-cholinergic receptors. The beta-adrenergic receptors (BARs) are composed primarily of a single class of high affinity, beta 2-subtype receptors as judged by [3H]dihydroalprenolol antagonist binding studies. The BARs are functional inasmuch as isoproterenol stimulation increases both intracellular cAMP content and [3H]mannose incorporation into endogeneous glycoproteins. Differences in ultrastructure and neuroreceptor composition between A253 and other immortal salivary tumor cell lines are discussed.

Cell Line↗
PubMed1989

Lack of acute effects of methotrexate on rat parotid salivary gland function.

Like other cytotoxic drugs, methotrexate (MTX) produces adverse reactions in oral tissues. Parotid gland function was examined, in vivo and in vitro, 18 h after MTX administration (15 mg/kg, i.p.). No salivary effects could be detected consistently. In addition, the integrity of the oral mucosa remained intact. Thus, at this dose, MTX does not exert an acute cytotoxic effect either on a rapidly replicating oral tissue like the mucosa, or on tissue with a slow turnover rate like the parotid.

Animals↗
PubMed1989

Hyperostosis corticalis generalisata: surgical management and long-term follow-up of one patient.

A 24-year-old woman presented for treatment of her distorted facial appearance. She showed marked widening of the face and skull, which had first become noticeable in childhood. Significant thickening of the cortical bone was seen radiographically throughout the skeleton. Routine laboratory and endocrinological tests showed normal results. These findings, together with a family history of bone disorder, led to the diagnosis of hyperostosis corticalis generalisata. The lower border of the mandible was resected, resulting in improved facial appearance. During the 8-year follow-up, no changes were seen with regard to the mandible.

Adult↗
PubMed1987

Fluid secretion rates from mouse and rat parotid glands are markedly different following pilocarpine stimulation.

1. Parotid saliva production in two commonly employed laboratory animals, mouse and rat, was studied following pilocarpine stimulation. 2. When normalized to body wt, average parotid saliva output rates in mice were 3-4-fold greater than those observed in rats. When parotid salivary flow rates were normalized to gland weight, mice still displayed 2-3-fold higher values than rats. 3. The Na+ and K+ content of parotid saliva showed small differences between the two species, while saliva from rats contained 3-fold higher protein levels than observed with mice.

Animals↗
PubMed1986

Juvenile recurrent parotitis: clinicoradiologic follow-up study and the beneficial effect of sialography.

In twenty-two children juvenile recurrent parotitis (JRP) was diagnosed on the basis of age at onset, duration of parotid swelling episodes, frequency of attacks, lack of pus formation, and typical sialograms. Age at onset and severity of the disease varied widely. There was a high incidence of upper respiratory tract infection, and in some cases a familial history of JRP was noted. The sialograms revealed acinar and ductal atrophy and severe sialectasis. A dominant feature was impaired glandular function. The follow-up period was notable for a striking decrease in the number of incidents of glandular swelling regardless of the patient's age at the time of his or her first visit to our clinic. Since drug treatment was administered prior to our first examination and no medicaments were prescribed by us, the improvement in the clinical status of the patients is attributed to the sialographic procedures.

Child↗
PubMed1986

Alveolar bone repair following extraction of impacted mandibular third molars.

Bone regeneration following extraction of impacted mandibular third molars was measured on 83 preoperative and postoperative radiographs. The patient sample was divided into two age groups, 20 to 29 years and 30 to 50 years. Postoperatively, there was an average net gain of 2.15 mm in bone level. The degree of bone healing is affected primarily by age and, to a lesser extent, by the presence of generalized inflammation (periodontitis).

Adult↗
PubMed1986

A radiographic survey of periapical jawbone lesions.

A radiographic survey of the jawbone adjacent to the teeth revealed a high incidence of bone pathosis in 889 randomly chosen patients. Jaw lesions, nearly all inflammatory, were present in every second person. Bone-destructive inflammatory processes (rarefying osteitis) were the most frequently encountered lesions, occurring in both the maxilla and the mandible. Bone-appositioning inflammatory processes (condensing osteitis), on the other hand, appeared mostly in the mandible, very often involving the first molar, thus indicating the differing biologic behavior of the two jawbones. Other bony manifestations in the mandible, such as enostosis and periapical cemental dysplasia, although relatively rare, also formed part of the picture. In light of the absence of related symptoms, the clinical significance of these widely prevalent periapical lesions has to be reconsidered.

Alveolar Process↗
PubMed1986

A novel and non-invasive method for the removal of salivary gland stones.

A non-invasive method for salivary gland stone disintegration by shock waves is proposed. An in vitro experiment, in which a large sialolith was subjected to shock waves produced by a Dornier lithotriptor, demonstrated the complete destruction of the stone. The advantages of the method and the need for modification of the existing equipment is discussed.

Aged↗
PubMed1986

Thyroid papillary carcinoma presenting as jaw and parotid gland metastases.

A slowly progressing colloidal goiter of 20 years standing was excised in a 67-year old woman. Two years later, a metastatic tumor inducing facial swelling was diagnosed radiologically in the left parotid gland and left ascending mandibular ramus. The incisional biopsy confirmed papillary carcinoma of thyroid origin. The patient refused treatment. Six months later, she returned to the clinic and presented with advanced destructive changes of the involved structures. This rare case of unrestricted malignant growth may shed light upon the sequence and mode of metastatic invasion.

Aged↗