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Biomedical subjects

Y Matsukado

Publications and source records attributed to Y Matsukado.

At least 91 records · Page 5Linked to original sources
PubMed1985

Syringomyelia associated with a foramen magnum meningioma.

In a 14-year-old boy with a meningioma at the foramen magnum extending to C-2, cervical syringomyelia was found on metrizamide computed tomographic myelography. The mechanism of syrinx enhancement on delayed computed tomographic scanning was considered to be due to transneural passage of metrizamide into the spinal cord. Long-standing spinal block may be responsible for development of syringomyelia. Syringomyelia associated with spinal extramedullary tumors was reviewed in the literature.

Adolescent↗
PubMed1985

Cervical dermal sinus associated with meningitis and motor paralysis.

A patient is described with a congenital dermal sinus in the high cervical region who developed recurrent episodes of purulent meningitis associated with fluctuating paresis of the extremities. Subtotal excision of the dermal track in the cord resulted in good functional recovery.

Humans↗
PubMed1985

Dephosphorylation of microtubule-associated protein 2, tau factor, and tubulin by calcineurin.

Calcineurin dephosphorylated microtubule-associated protein 2 (MAP2) and tau factor phosphorylated by cyclic AMP-dependent and Ca2+, calmodulin-dependent protein kinases from the brain. Tubulin, only phosphorylated by the Ca2+, calmodulin-dependent protein kinase, served as substrate for calcineurin. The concentrations of calmodulin required to give half-maximal activation of calcineurin were 21 and 16 nM with MAP2 and tau factor as substrates, respectively. The Km and Vmax values were in ranges of 1-3 microM and 0.4-1.7 mumol/mg/min, respectively, for MAP2 and tau factor. The Km value for tubulin was in a similar range, but the Vmax value was lower. The peptide map analysis revealed that calcineurin dephosphorylated MAP2 and tau factor universally, but not in a site-specific manner. The autophosphorylated Ca2+, calmodulin-dependent protein kinase was not dephosphorylated by calcineurin. These results suggest that calcineurin plays an important role in the functions of microtubules via dephosphorylation.

Animals↗
PubMed1985

Clinical and histopathological characteristics of gonadotropin-producing pituitary adenomas.

The clinical and histopathological characteristics in six cases of gonadotropin-producing adenoma are presented. Definitive diagnosis was made by the determination of gonadotropin levels in culture medium. Several authors have reported that gonadotropin-producing adenomas are very rare; however, hormonal assay of adenoma cell culture medium may indicate the real incidence of gonadotropin-producing adenomas to be greater than is thought. In reported cases, practically no endocrinological symptoms have been found suggesting increased gonadotropin levels, and basal values of plasma gonadotropins have been reported as only slightly over the normal range. Gonadotropin-producing adenomas may have been misdiagnosed as nonsecreting adenomas. The clinical characteristics of gonadotropin-producing adenomas can be summarized as follows: 1) a tendency for more rapid growth than nonsecreting adenomas; 2) prominent suprasellar extension with marked enhancement on computerized tomography; and 3) diminished response of luteinizing hormone (LH) alone in response to LH-releasing hormone (LH-RH) stimulation, and the ratio of peak follicle-stimulating hormone to peak LH in the LH-RH stimulation test is more frequently over 1:1 in cases of gonadotropin-producing adenoma than in cases of nonsecreting adenoma and craniopharyngioma. Immunoperoxidase staining revealed two kinds of adenoma cells, one intensely and the other faintly stained. Abundant mitochondria and few secretory granules were characteristic electron microscopic features. Oncocytic transformation of adenoma cells was suggested by immunoperoxidase staining and the electron microscopic appearance, and may suppress the elevation of circulating plasma gonadotropin levels. Thus, hormonal assay of adenoma cell culture medium and immunoperoxidase staining are essential for definitive diagnosis of gonadotropin-producing adenomas.

Adenoma↗
PubMed1985

[Treatment of meningeal carcinomatosis--neocarzinostatin perfusion therapy in the CSF pathway].

The authors presented the results of perfusion chemotherapy in the CSF pathway with neocarzinostatin (NCS) for the treatment of meningeal carcinomatosis. In three cases of stomach cancer and one case of malignant lymphoma, cranial polyneuropathy, progressive hydrocephalus and positive cytology of the CSF were found during treatment of malignant tumors. NCS therapy was performed by means of perfusion from the spinal subarachnoid space to the ventricle utilizing Ommaya's reservoir, or simply by repeated lumbar punctures. In all of four cases the number of malignant cells in the CSF was significantly diminished, and temporary neurological improvement was observed until the patient's death due to advanced primary lesions. These results indicated that in cases of meningeal carcinomatosis, NCS perfusion therapy using the CSF pathway was a much more favorable method than treatment with other chemotherapeutic agents with less noticeable side effects.

Adult↗
PubMed1985

[Origin of component N16 in short latency somatosensory evoked potentials (SSEP) to median nerve stimulation--correlation between component N16 and thalamus].

Short latency somatosensory evoked potentials (SSEP) to median nerve stimulation consists of four main subcortical components, namely P 9, P 11, P 13 and N 16 which appears before cortial N 18. However, the origin of component N 16 is a subject of controversy. In an attempt to learn about the generator source(s) of component N 16, SSEP was recorded from 25 patients with various focal lesions of the brain stem and/or thalamus, and abnormalities of the each potential was correlated to the clinically and radiologically defined site of the lesions. Furthermore, the effects of the different frequency in stimulation were also investigated in 6 normal subjects, because latency changes of each component might contribute to the understanding of the generation. Recordings were obtained from 13 patients with brain stem lesion which included 3 cases with pontine hemorrhage, 3 cases with pontine tumor, 3 cases with cerebello-pontine angle tumor, one case of pontine angioma, one case of chordoma, one case of tentorial tumor and one case of MLF syndrome. SSEP changes in these cases were classified into four types as follows: type 1: no response over the base line was recorded, type 2; some responses over the base line were recorded but N 16 was uncertain, type 3; component N 16 was clearly identified but its latency was significantly prolonged, type 4; component N 16 was divided into two peaks. Bilateral abnormality on SSEP with splitted combination of these four types in various degree was observed. Furthermore, these SSEP abnormalities were seen even in the some cases without sensory disturbance. On the other hand, component N 16 was clearly identified in all 12 patients with thalamic lesion which included 11 cases with thalamic hemorrhage and one case with thalamic tumor on the effected side. Comparison of latency and amplitude between normal side and affected side statistically showed no laterality of components P 9, P 11 and P 13, but a tendency of delay in latency of component N 16 on the affected side. Different stimulus repetition rate revealed some other characteristics of each component. Electrical stimuli to median nerve at the wrist were delivered at rates of 3, 6, 9, 12, 15, 18, 21, 24 and 27 Hz. Latencies of components P 9, P 11, P 13, N 16 in Fro.-Cv 7 lead and component N 18 in Par.-Erb lead were measured and all latency changes were calculated relative to the 3 Hz stimulation.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1985

[Isolated fourth ventricle simulating the Guillain-Barré's syndrome].

Recently the symptoms caused by isolated dilatation of the fourth ventricle have become the subject of discussion under the name of the Isolated Fourth Ventricle (IFV). IFV is caused by occlusion of the aqueduct of Sylvius as well as the foramen of Luschka and Magendie after shunt procedure for the internal hydrocephalus, although the etiological back-ground is not fully understood yet. Most of the symptoms of hitherto reported cases are due to dysfunction of the lower cranial nerve and cerebellum. We reported an interesting adult case of IFV, whose symptoms were very much simulating the Guillain-Barré's syndrome and were completely relieved with fourth ventricle-peritoneal shunt. Clinical history was analyzed with repeated CT scans and was discussed with review of the literature.

Adult↗
PubMed1985

[Origin of the early components of somatosensory evoked potentials by the posterior tibial nerve stimulation--a comparative study of median nerve stimulation in clinical cases].

In order to determine the generation sites of short latency somatosensory evoked potentials to the posterior tibial nerve stimulation, scalp topography was performed on 10 normal subjects in the two different band-pass recordings, i.e., wide band-pass filter (5-3000 Hz) and narrow band-pass filter (100-1000 Hz). Furthermore, comparative study of the changes of evoked potentials between posterior tibial nerve stimulation and median nerve stimulation was carried out in 22 cases with well localized lesion of the central nervous system in the same wide band-pass filter setting. The early components of somatosensory evoked potentials elicited by the posterior tibial nerve stimulation were obtained as P 30, N 34, and P 38 in the wide band-pass filter, and P 29, N 32, P 36 in the narrow band-pass filter. Components P 30, N 34 and components P 29, N 32 were widely distributed on the scalp, but were disappeared on the scalp-scalp recording. These results suggested all those components were generated from the deep subcortical structures. In the case with high cervical lesion, component P 30 at the posterior tibial nerve stimulation was remarkably prolonged in latency, and component P 13 at the median nerve stimulation was disappeared. P 30-N 34 interpeak latency at the posterior tibial nerve stimulation was prolonged in the case with pontine lesion, while P 13-N 16 interpeak latency at the median nerve stimulation was also prolonged. In the cases with thalamic and internal capsular lesion, P 30 and N 34 at the posterior tibial nerve stimulation and P 13 and N 16 at the median nerve stimulation were all preserved in normal range. These results revealed that components P 30 and N 34 were almost identical to components P 13 and N 16, respectively. On the other hand, component P 38 at the posterior tibial nerve stimulation was suppressed or disappeared in the cases with well localized lesion at the midcentro parietal region, that includes the primary foot sensory area.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗
PubMed1985

[Bilateral complete deafness following head injury in a child].

A case of head injury is reported because it presented such an unusual symptom as sudden, bilateral complete deafness. An 11-year-old boy was involved in a traffic accident while riding on a bicycle. He was admitted immediately after the accident in semicomatose state. The pupils were isocoric and pupillary light reflex was normal. Conjugate deviation to the right was seen. Oculo-cephalic response was absent. X-rays of his skull showed two linear fractures in the occipital bone. CT scan of the head showed symmetrical ventricular dilatation which was suspected to be a sequela of asphyxia at his birth although there was no obvious finding of cerebral contusion. His mental and physical development had been uneventful. One week after admission, his consciousness improved to some extent and at that time right hemiparesis and right infranuclear facial palsy were revealed. One month after the accident, he became alert and able to eat and to read the books on the bed, and then bilateral deafness was noticed. Audiometry showed that hearing was lost completely to both high and low notes, and there was absence of bone conduction bilaterally. Auditory brainstem response test revealed no response from wave I through wave V bilaterally. Right hemiparesis and right infranuclear facial palsy completely subsided and his mental and intellectual state became normal. He was discharged ambulatorily in good condition except for bilateral complete deafness. Now he is leading a useful life and attending a prefectural deaf and mute school.(ABSTRACT TRUNCATED AT 250 WORDS)

Audiometry↗
PubMed1985

[Hydrocephalus due to membranous obstruction of the fourth ventricle aperture].

Three cases of hydrocephalus due to membranous obstruction of the fourth ventricle aperture are reported. Patient's age was 4, 34 and 68 years old and they complained of slowly progressive cerebellar ataxia, gait disturbance and other hydrocephalic symptoms. CT scan revealed symmetrical dilatation of lateral ventricles, and, especially, the fourth ventricle aperture was confirmed by ventriculography or metrizamide CT cisternography. Suboccipital craniectomy was performed in all cases and cerebellum was of normal shape and semilucent membrane was found obliterating the foramen of Magendie. Histological finding of the membrane was chiefly composed of fibroblast, but inflammatory evidence suggesting any particular etiological process. The cause of membranous obstruction was undetermined and obsolete infectious or inflammatory change was suspected.

Adult↗
PubMed1985

[Internal carotid aneurysmal formation following spontaneous regression of the dural arteriovenous malformation in the posterior fossa--a case report].

The patient was first admitted on August 19, 1975 with 5 years' headache and tinnitus. Physical examination revealed bruit over the left mastoid area. Left angiography, performed in August, 1975, revealed a dural arteriovenous malformation, which was supplied by enlarged left middle meningeal artery, occipital artery, meningohypophyseal artery and superior cerebellar artery and was draining into the left sigmoid sinus. At the first operation, the left external carotid artery was ligated at the neck, and then coagulation of dural vessels was performed through left temporo-occipital craniotomy. Tinnitus and bruit were disappeared after operation. Postoperative right angiogram showed no residual dural AVM, however, ligation of the right external carotid artery was required to reduce symptomes. In June, 1979 the left brachial arteriography was performed, and revealed a dural AVM around the left sigmoid sinus supplied by anastomotic vessels between external carotid artery and cervical artery arising from the vertebral artery. Because of subarachnoid hemorrhage, repeated angiography in April, 1982, revealed progressively enlarging dural AVM, although no aneurysm was seen in the left internal carotid arterial system. The patient readmitted on October, 28, 1983 with severe headache and confusion. CT scan showed slightly high density in the left basal cistern. Angiogram showed no dural AVM and a saccular aneurysm arising from the left internal carotid artery at C2 portion, which was successfully clipped by surgery. Only two cases of spontaneous regression of dural AVM in the posterior fossa were reported previously, and the authors added a case, which showed a newly developed aneurysm after spontaneous regression of the posterior fossa dural AVM.

Carotid Artery Diseases↗
PubMed1985

[Ossifying fibroma of the temporal bone].

A case of ossifying fibroma of the cranial vault is described. Several reports emphasized the rare existence of this lesion limiting in the cranial vault. The patient was a 76-year-old woman who suffered mild headache in the parietal region after a trivial head trauma. Physical and neurological examination were normal. Plain skull X-P revealed irregularly bordered, 4 X 4 cm sized radiolucent area in the left temporal bone. The bone scintigraphy using 99mTc-MDP showed an abnormal uptake like a doughnut. Levels of serum P, Ca and alkaline phosphatase were within normal range. A tumor was softer than normal skull, and undertaken piecemeal removal. The dura was normal. After the total removal of the tumor, cranioplasty using Resin plate was performed. Microscopically the lesion was composed immature, irregular spicules of bone and fibrous tissue. Abundant fibroblasts were arranged in a random fashion in the stroma. Characteristically, the spicules of bone surrounded by rimming of osteoblasts. Ossifying fibroma is a benign fibroosseous tumor. Although this tumor is typically found in the maxillary sinus and mandible, it has also been reported in the paranasal sinuses, frontal, ethmoid, sphenoid bone and orbital roof of the young adult. But previously reported cases involving the cranial vault alone were only 7 cases. Etiology of ossifying fibroma is almost unknown.

Aged↗
PubMed1984

Migration of a dissected peritoneal shunt catheter into the scrotum.

Migration of a dissected peritoneal piece of the shunting material into the scrotum was encountered in a 1-year-old boy who had received a V-P shunt. Removal of the migrated shunt tube by inguinal exploration and herniorrhaphy were performed, and another V-P shunt was installed simultaneously. This case was considered worthy of reporting as a rare complication of a V-P shunt, and the causal mechanism is discussed with a review of the literature.

Cerebrospinal Fluid Shunts↗