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Biomedical subjects

Y Morimoto

Publications and source records attributed to Y Morimoto.

At least 559 records · Page 31Linked to original sources
PubMed1978

Pharmacological properties of 6-(o-chlorophenyl)-8-ethyl-1-methyl-4H-s-triazolo[3,4-c]thieno[2,3-e] [1,4]diazepine (Y-7131), a new anti-anxiety drug.

6-(o-Chlorophenyl)-8-ethyl-1-methyl-4H-s-triazolo[3,4-c]thienol[2,3-e][1,4]diazepine (Y-7131), a new derivative of the thienodiazepines, had marked activities in antipentylenetetrazole effect in mice, attenuation of conflict behavior in rats, inhibition of aggressive behavior induced by hypothalamic stimulation in cats and muscle relaxant effects in normal and decerebrate cats. Y-7131 had weak activities in anti-MES effect in mice and loss of righting reflex in mice. The acute toxicity of Y-7131 was considerably lower than that of diazepam. No significant autonomic or neuroleptic effects were noted. Y-7131 appears to be a characteristic and potent anti-anxiety agent different from the benzodiazepines.

Aggression↗
PubMed1975

[Effects of various psychotropic drugs on self-stimulation behavior in the rat].

Effects of various psychotropic drugs on tegmental and hypothalamic self-stimulation behavior in rats with chronically implanted electrodes in the brain were studied. Effects of elecrtical stimulation in several brain structures on self-stimulation behavior and influences of drugs on the stimulation effect were also investigated. The hypothalamic self-stimulation behavior was more markedly inhibited by chlorpromazine than the tegmental self-stimulation, whereas the latter was more strongly inhibited by diazepam. The effects of pentobarbital on the self-stimulation behavior were similar to those of diazepam. Methamphetamine facilitated both the tegmental and hypothalamic self-stimulation behavior. Suppressive effect of hypothalamic stimulation on the tegmental self-stimulation behavior was inhibed by chlorpromazine, while those of amygdaloid and septal stimulation were augmented. All the effects of hypothalamic, amygdaloid and septal stimulating on the tegmental self-stimulation behavior were inhibed by diazepam and pentobarbital, while these were facilitated by methamphetamine. Suppressive effects of tegmental, amygdaloid and septal stimulation on the hypothalamic self-stimulation behavior were all facilitated by both chlorpromazine and methamphetamine. The effects of amygdaloid and septal stimulation on this behavior were inhibed by diazepam and pentobarbital, while those of tegmental stimulation were enhanced. The effects of imipramine, in all experiments, were variable in each rat and not significant.

Animals↗
PubMed1975

Circadian rhythm of plasma corticosteroid in adult female rats: chronological shifts in abnormal lighting regimens and connection with oestrous cycle.

The circadian rhythm of plasma corticosteroid (CS) levels in adult female rats was studied chronologically under the following conditions: normal light-dark (LD), inverted light-dark (DL), constant dark (DD) and constant light (LL). Animals were accustomed to LD condition for 7 days before exposure to each abnormal lighting regimen. Normal circadian rhythm established under LD condition was clearly inverted on the third day of DL regimen, and the inverted rhythm persisted thereafter under DL condition. The circadian CS rhythm persisted essentially unchanged throughout DD condition, but lost its regular periodicity showing "free running" and changed day by day under LL condition. The average CS levels over a 24 h period were higher under LL than under DD condition. Plasma CS levels in each lighting regimen exhibited diurnal variations regardless of the vaginal smear patterns of autopsied animals. Exposure of rats to LL for 21 days made the circadian CS rhythm flat, but induced persistent oestrus in only a few animals. The data suggest that (1) an unexpectedly rapid inversion of the circadian CS rhythm occurs if animals are exposed to inverted light-dark environment; (2) constant darkness seems to be a near-natural environment for rats, and changes little of the pre-established circadian CS rhythm; (3) constant light, on the contrary, is assumed to be a stress for rats, and disrupts the circadian CS rhythm and elevates CS levels; (4) the change in circadian CS rhythm in adult female rats is not mediated by a change in gonadal function and the two conditions may not be connected directly with each other.

Adrenal Cortex Hormones↗