Sulfaquinoxaline, a possible means for the control of the house dust mite Dermatophagoides pteronyssinus.
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Biomedical subjects
Publications and source records attributed to Y Mumcuoglu.
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House dust samples from rural districts contain more mite species (in particular stored food mites) than samples from urban areas, and the total number of mites is also approximately three times greater. 77 patients from rural districts, 48 of whom allergic to their own house dust, and 29 controls, were tested with mite extracts from Dermatophagoides pteronyssimus, D. farinae, Chortoglyphus arcuatus, Acarus siro, Glycyphagus destructor and Tyrophagus putrescentiae, and a house dust extract. Out of 32 patients who showed positive scratch tests to one or more mite extracts, 29 (90,6 percent) reacted positively to D. pteronyssimus, 25 (78.1 percent) to D. farinae and from 7 to 12 (20-40 percent) to the stored food mites. Out of the 48 patients allergic to their own house dust, 27 (56.2 percent showed positive reactions to D. pteronyssinus, 24 (50.0 percent) to the house dust extract and 21 (43.7 percent) to D. farinae. Only 5 (17.2 percent) out of the 29 controls reacted positively to one or more of the solutions tested. The stored food mites showed 2.5 to 4.5 times more positive reactions in the rural patients compared with the results obtained in urban patients. The importance of these mites in the sensitization of patients from rural districts is discussed.
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With Dermatophagoides pteronyssinus and house-dust sensitized guinea-pigs showed cross-reactions between house-dust, D. pteronyssinus and D. farinae in the Schultz-Dale test. Euroglyphus maynei gave positive reactions only in animals sensitized with D. pteronyssinus. The stored food mites Tyrophagus putrescentiae, Chortoglyphus arcuatus and Glycyphagus destructor and the rearing medium (horse dander/yeast) did not cause any cross-reactions in any test group.
The allergenic properties of the nine mite species prevalent in the house dust of northwestern Switzerland (Basel and surroundings) were studies. For the preparation of mite extracts, the average weight of each species was first determined and then the number per culture glass counted. Thus the extracts were prepared according to the weight of the mites. They were tested on 115 patients with ashma and/or rhinitis. Tests with patients own house dust and with a human dander/yeast mixture, which served as culture medium for the mites, were carried out simultaneously. Test results were either positive or negative for all substances in 93 patients (80 per cent). Dermatophagoides pteronyssinus, D. farinae and Euroglyphus maynei caused the most frequent and most severe reactions. The species Glycyphagus destructor, G. privatus, Chortoglyphus arcuatus, Gohieria fusca, Tyrophagus putrescentiae and Acarus siro seem to play a less important role, if any, in house dust allergies.
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The prevalence of the house-dust mite Dermatophagoides pteronyssinus in four different kinds of test mattresses was investigated. In a first series of experiments the mites showed no preference to any of the mattresses - irrespective of the stuffing material - when the surface was smooth and unstitched. In a second series of experiments two buttons each were sewed on on both sides of the mattresses. Subsequently the mites showed a distinct preference to the depressed area around the buttons. These findings were confirmed in used mattresses provided by patients. The importance of these "nishes" in relation to mite allergies is discussed.
Seasonal examinations of dust samples from Basel and surroundings have shown that the number of mites increases during the months of August through October. Dust samples were then collected from various climatic regions of Switzerland during August and tseptember. Samples originating from places where the temperature was above 12 degrees C and relative humidity above 68% over a period of 4-5 months yielded a high mite count. Regions with these climatic conditions are therefore unfavourable for patients allergic to house-dust.
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