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Biomedical subjects

Y Nakamizo

Publications and source records attributed to Y Nakamizo.

13 recordsLinked to original sources
PubMed1985

Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species.

A series of compounds, which are analogues of 2,2'-dithiobis(benzamide), were synthesized and tested for in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv including resistant strains against streptomycin, kanamycin, or isonicotinic acid hydrazide. MICs of these compounds against atypical mycobacteria, Mycobacterium kansasii and Mycobacterium intracellulare were also examined. Structure-activity relationships were found in a series of (acyloxy)alkyl ester derivatives depending upon the length of alkyl carbon chain. The MIC of the most potent compound, 2,2'-dithiobis[N-[3-(decanoyloxy)propyl]benzamide] [56] was superior or at least equivalent to streptomycin, kanamycin, and ethanbutol. All the compounds showed no cross-resistance between the current antitubercular agents.

Animals↗
PubMed1974

Lectins detecting group C streptococci.

Lectin of Wisteria floribunda specifically agglutinates group C streptococci. The reaction is strongly inhibited by N-acetyl-d-galactosamine, slightly by lactose, and not at all by galactose. The utility of the simple test of the lectin with group C streptococci is discussed.

Agglutination↗