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Biomedical subjects

Y Narimatsu

Publications and source records attributed to Y Narimatsu.

At least 19 recordsLinked to original sources

[CT anatomy of the caudate lobe of the liver].

The anatomy of the portal vein branches in the caudate lobe of the liver was studied in 20 patients by double-phase CT arterial portography (DP-CTAP). DP-CTAP provided excellent images of the portal venous system in the first phase and the perfusion defects of intrahepatic tumors in the second phase. From DP-CTAP images of the first phase, a sufficient number of interpolated images were created for a smooth paging display. The ramifying structures of the portal system were traced on the monitor using the tracking ball. This method was found to be very effective and reliable for the anatomical assessment of the caudate lobe. The number and origins of the caudal portal branches were investigated in each case, and the caudate lobe of the liver could be divided into right and left segments.

Humans

[Percutaneous transluminal angioplasty for stenotic dialysis arterio-venous fistulas].

From December 1982 to January 1991, we performed fistulography on 40 patients who complained functional failure of arterio-venous dialysis fistula. And percutaneous transluminal angioplasty (PTA) was attempted on 15 patients (19 times) who revealed marked fistula stenosis. Initial successful rate was 78.9% and patency rate was 56.2% in the first 6 months. (75% in the first 6 months when angioplasty was initially successful). We describe the method of fistulography and PTA for stenotic dialysis fistulas, and evaluate the usefulness of PTA. And also we introduce our attempts for improving the initial successful rate and patency rate. In conclusion, when dialysis arterio-venous fistula is stenotic but not occlusive, PTA should be considered first before surgical treatment is done.

Adult

Transcatheter hepatic arterial chemoembolization using epirubicin-lipiodol: experimental and pharmacological evaluation.

The experimental and pharmacological characteristics of various formulations of an anticancer agent (epirubicin, EPI) and lipiodol were evaluated in vitro and in vivo. Three forms of EPI-lipiodol, i.e., an oil-in-water type of emulsion (O/W type), a water-in-oil type of emulsion (W/O type), and a suspension (S type), were prepared and investigated for their stability. An O/W-type emulsion using a stock solution of Iopamidol as the solvent for EPI was the most stable form in the stationary state in vitro. In 16 patients with malignant liver tumors (14 hepatocellular carcinomas and 2 liver metastases), the three forms of EPI-lipiodol were injected into the proper hepatic artery. The plasma EPI level was monitored periodically and analyzed pharmacokinetically. No significant difference in the pharmacokinetics of EPI was detected among the O/W, W/O, and S types.

Aged

[Fallopian tube recanalization with a catheter system--experience in the use of a balloon catheter].

Fallopian tube obstruction is one of the most difficult problems in the treatment of infertility. This report gives the results of a pilot study on the transcervical recanalization of the occlusive fallopian tube. Selective catheterization of the uterine cornu was applied through a balloon catheter, which was wedged at the internal uterine os. In 16 occlusive fallopian tubes of 11 cases, the catheterization procedure was attempted and accomplished with a 87.5% success rate. Recanalization was successful in 75.0% of the affected tubes. Subsequent pregnancy was confirmed in three cases. This convenient technique is safe and effective and it will be accepted as the first choice in the diagnosis and treatment of fallopian tube obstruction.

Adult

[Imaging diagnosis of genitourinary tract tumors].

Recent advance of imaging technique have brought great advantages for management of genitourinary tract tumors. We described few examples of changes in this field from our experience. Many asymptomatic masses are discovered in the kidney and adrenal gland associated with wide clinical application of CT and US. In the kidney, the greater part of incidental masses are renal cell carcinomas (RCC) and the rate of such cases has been increasing. When small RCC is diagnosed without any clinical symptoms, better survival would be expected. Many adrenal incidental mass are also discovered by routine use of CT for abdominal workup. Since greater part of these masses are benign nonfunctioning adenomas, correct diagnosis should be made in order to avoid inappropriate surgery. Rapid development of MR also resulted in some changes in the diagnosis of urinary tract tumors. However, MR cannot be used as a screening method. For staging of RCC, intravascular or adjacent organ invasion was well determined with MR compared with CT. Differentiation of adrenal carcinomas from nonfunctioning adenomas is suggested by the difference of signal intensity on T2 weighted images. Fast spin echo scan with GD-DTPA enhancement is new MRI technique separating bladder mucosal layer from muscle layer as hyper-intensity area. Using this method, diagnostic accuracy of deep muscle invasion for bladder tumor would be improved.

Adrenal Gland Neoplasms

Renal devitalization with ethanol injection in management of patients with advanced hypernephroma.

Transcatheter injection of ethanol into the renal artery was utilized in 11 patients with hypernephromas, clincally staged C or D, in an attempt to produce renal devitalization. Complete disappearance of the tumor neovascularity was achieved in 9 of 11 patients. Renal divitalization with ethanol injection is safer and more effective than the embolizing technique utilized hitherto and should be included in the primary treatment of hypernephroma in selected cases or in conjunction with other procedures to induce chemical nephrectomy.

Adenocarcinoma

Vasoconstrictive effects of prostaglandin F2 alpha angiography on colonic lesions.

In a study of 54 patients with a variety of lesions, prostaglandin F2 alpha pharmacoangiography produced vasoconstrictive effects in both neoplastic and inflammatory lesions of the colon. These effects occurred only at the affected sites and their immediate vicinity. Vasoconstriction seemed to correlate directly with the vascularity of the lesion, rather than with pathogenesis. Less marked vasoconstriction was seen in renal lesions. No vasoconstrictive effects were recognized in liver, soft tissue, or bone tumors. Thus prostaglandin F2 alpha acts as a vasodilator in normal human colonic vessels, while it acts as a vasoconstrictor in colonic lesions. The potential use of prostaglandin F2 alpha in the control of bleeding colonic lesions is also discussed.

Adult