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Biomedical subjects

Y Naruse

Publications and source records attributed to Y Naruse.

105 records · Page 6Linked to original sources
PubMed1982

An epidemiological study on total and specific IgE levels in Japanese schoolchildren.

Total serum IgE, and specific serum IgE against mites, Ascaris and Japanese cedar pollen were surveyed in 251 schoolchildren by a radioimmunoassay method. These children, aged from 10 to 13 years and living in a rural Japanese town, were selected according to one-third random population sample. A high concentration of total serum IgE (700 u/ml or more) was found in thirty-one children (12 X 3%). The sex ratio of these children, boys to girls, was 2 X 1:1. The cross-sectional and 6-year follow-up study of total IgE levels showed that they decreased with advancing age. Total IgE levels were significantly related to each of three specific IgE species investigated in this study. The levels of these three specific IgE's were also significantly related to each other. Schoolchildren with high specific IgE levels against mites have had significantly more asthmatic histories compared to children with low specific IgE levels. Such a relationship was not observed for total IgE levels and another two specific IgE species.

Adolescent↗
PubMed1979

Studies on the metabolism and toxicity of dinitrotoluenes. Toxicological study of 2,4-dinitrotoluene (2, 4-DNT) in rats in long term feeding.

2, 4-Dinitrotoluene (2, 4-DNT) was incorporated at the level of 0.5% in a standard commercial diet and fed ad lib. to male rate for 6 months. Significant changes were noted in the body weight, organ weight, behavior, mortality, and biochemical analysis of blood and serum of rats ingesting 2, 4-DNT. Furthermore, it was found that the ingestion of 2, 4-DNT affected on the activities of drug metabolizing enzymes in liver microsomes.

Animals↗
PubMed1978

Studies on the metabolism and toxicity of dinitrotoluenes--on the absorption and excretion of tritium-labelled 2,4-dinitrotoluene (3H-2, 4-DNT) in the rat.

In order to investigate the detailed absorption and excretion of 2, 4-DNT in the rat, after the single oral administration of 3H2, 4-DNT, the time-course of radioactivity level in blood, liver and digestive organ contents, and of biliary, faecal and urinary excretion were observed. Radioactivity level in blood reaches a peak at 6 hr after the administration and its half-life was about 22 hr. Maximum level of radioactivity in the liver was observed at 6 hr after the administration as well as in the blood. In contrast with the radioactivity levels in blood and liver, amount of radioactivity in small intestine content is markedly decreased for 6 hr after administration. In the biliary excretion, about 10 per cent of the radioactivity administered was excreted in bile within 24 hr. The excretion rate is rising steadily from 6 hr after administration and its peak time was 9-10 hr. In the faecal excretion, the most of the excretion radioactivity was concentrated on 6-9 hr. In the faecal excretion, the most of the excretion radioactivity was concentrated on 6-9 hr faeces as reflected with the biliary excretion pattern. On the other hand, the most of the urinary excretion radioactivity was concentrated on 0-6 hr urine.

Absorption↗
PubMed1977

Studies on the metabolism and toxicity of dinitrotoluenes--on excretion and distribution of tritium-labelled 2,4-dinitrotoluene (3H-2,4-DNT) in the rat.

In order to investigate the excretion and distribution of 2,4-DNT in the rat, 3H-2,4-DNT was synthesized by nitration reaction of 3H-toluene. About 21.3 per cent of the single orally administered radioactivity was excreted in the 1st day-faeces. The amounts of radioactivity in the 2nd day- and 3rd day-faeces were to be about 4.1 and 1.1 per cent, respectively. About 13.5 per cent of the radioactivity administered was excreted in the 1st day-urine, but after the 2nd day the excretion of radioactivity was to be trace. In all, about 46 per cent of the radioactivity administered was excreted in the faeces and urine during the 7 days. Seven days after administration relatively high levels of radioactivity were retained in adipose tissue, skin, and liver, however, the amounts of remaining radioactivity were to be only 1.5, 0.6 and 0.4 per cent, respectively. The amounts of radioactivity of the other organs were to be trace.

Animals↗
PubMedDate not supplied

Pleural lavage cytology immediately after thoracotomy and before closure of the thoracic cavity for lung cancer without pleural effusion and dissemination: clinicopathologic and prognostic analysis.

BACKGROUND: The significance of intraoperative pleural lavage cytology (PLC) in lung cancer patients without malignant effusion remains undetermined in terms of staging, prognosis, and local management. METHODS: PLC was performed both after thoractomy and before closure of the thoracic cavity in 325 patients with lung cancer without malignant pleurisy. RESULTS: According to the PLC results (positive [+] or negative [-] after thoracotomy/before closure), the patients were classified as follows: group A (-/-), 262 patients; group B (+/-), 19; group C (-/+), 22; and group D (+/+), 22. In comparison with group A, group C showed more advanced stage with aggressive nodal involvement, and group D showed more advanced lung cancer related to pleural and nodal involvement, whereas group B showed characteristics similar to those of group A. The rate of pleural recurrence in group D was the highest (26%). In particular, pleural recurrence was seen in the patients with a relatively large number of adenocarcinoma cells in PLC after thoractomy. The patients in groups C and D, especially those with adenocarcinoma, showed poorer prognosis, but in a multivariate analysis, PLC status was not an independent prognostic factor. CONCLUSIONS: PLC status after thoractomy provides useful information in the detection of high-risk subgroup for pleural recurrence. Although PLC status is closely associated with survival, its prognostic value is not independent.

Adult↗
PubMedDate not supplied

A longitudinal study of serum ferritin concentration during the female adolescent growth spurt.

An 8-year longitudinal study of changes in serum ferritin concentration has been carried out with additional measurements of haemoglobin and serum iron in 39 schoolgirls aged 10 years at entry to the study. This laboratory data was analysed in relation to menarche and stature. The mean serum ferritin concentration declined significantly due to the occurrence of menarch, rather than to a growth spurt and showed the lowest level at the third year after menarche. Thereafter, it increased again. The prevalence of schoolgirls with latent iron deficiency, defined by a low serum ferritin concentration, normal haemoglobin and normal serum iron concentration, also increased after menarche, and reached its highest level (71.8%) at the third year after menarche. Although haemoglobin and iron concentration declined after menarche, these changes were not statistically significant except for haemoglobin at the second year after menarche. These findings show that serum ferritin concentration is a sensitive variable, and indicates that latent iron deficiency follows menarche rather than an increase in height velocity in adolescence.

Bone Development↗
PubMedDate not supplied

Significance of various anticoagulation therapies during use of a left ventricular assist device.

A multicomparative study to establish adequate anticoagulation therapy for left ventricular assist devices was undertaken by administrating various anticoagulants: heparin, a prostacyclin analogue combined with a protease inhibitor; thromboxane A2 synthetase inhibitor; or a protease inhibitor alone. Our investigation suggested that combined administration of prostacyclin analogue and protease inhibitor (FUT-175) is ideal anticoagulation therapy from the point of blood coagulation and fibrinolysis. Currently, however, sole administration of FUT-175 is adequate anticoagulation therapy during clinical use of left ventricular assist devices.

Anticoagulants↗
PubMedDate not supplied

Genetic and environmental effects on urinary kallikrein, catecholamines, sodium, potassium, urea nitrogen and inorganic sulfate sulfur levels in school-age twins.

A genetic analysis of twins at school was undertaken using as variables urinary concentrations of kallikrein, catecholamines, sodium and potassium which have been demonstrated to be associated with blood pressure levels. In addition to these variables, urinary concentrations of urea nitrogen and inorganic sulfate sulfur which are indices of protein intake were investigated. 35 pairs of monozygotic twins and 19 pairs of dizygotic twins aged from 6 to 14 years were examined. Variance and correlation tests for genetic analysis indicated that in school children, hereditary factors play a role in the control of urinary potassium, sodium and kallikrein excretion. However, with regard to the urinary excretion of catecholamines, urea nitrogen and inorganic sulfate sulfur, hereditary control is not so apparent.

Adolescent↗
PubMedDate not supplied

A servomatic pneumatic driver system for left ventricular assist devices.

A new ventricular assist device (VAD) pneumatic driver with a servomatic left atrial pressure (LAP) control mechanism was developed for easy and safe control of left ventricular assist devices. The negative driving pressure (NP) can be automatically varied to control the assisted circulatory flow (AF), comparing the patient's LAP with prescheduled LAP (s-LAP). Animal experiments revealed this servomatic control system to be useful.

Animals↗
PubMedDate not supplied

Combined administration of protease inhibitor and thromboxane A2 synthetase inhibitor for anticoagulation of a left ventricular assist device.

To establish ideal anticoagulant therapy for left ventricular assist devices (LVADs), a comparative study was made of a thromboxane A2 synthetase inhibitor, a protease inhibitor, and combined administration of the two. Results of the investigation indicate that combined administration of a thromboxane A2 synthetase inhibitor (OKY-046) and a protease inhibitor (nafamostat mesilate, FUT-175) provides ideal anticoagulant therapy during cardiac support using LVADs from the point of blood coagulation and fibrinolysis. Artificial hearts have come into practical use as left ventricular assist devices, and have contributed to the saving of many patients with severe postoperative low cardiac output syndrome, but they sometimes encounter severe complications, i.e. cerebrovascular bleeding, thromboembolism, infection, or multiple organ failure. It is very important, therefore, to control coagulation and fibrinolysis adequately during cardiac support by an LVAD.

Animals↗