[Preclinical study on method of recombinant adenovirus gene transfer to liver cells].
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Adenoviridae↗
Biomedical subjects
Y Nikawa
Publications and source records attributed to Y Nikawa.
Growth and/or acid production of Candida albicans on soft lining materials in vitro.
Effects of soft lining materials on the growth and/or acid production of Candida albicans were investigated using a simplified method monitoring the pH change in the growth medium. Reverse sigmoidal pH curves were observed with all samples and, as compared with acrylic, all soft lining materials inhibited fungal growth or acid production in the following way, i.e. delay of the beginning of a rapid and linear decline in pH, decreases in the rate of linear change in pH and increases in minimum pH. Further examinations using a surface-modified glass tube revealed that the order of Candida growth agreed with the relative hydrophobicity and adherence capacity of substrates, suggesting that this adherence capacity affected the yeast growth on their surfaces. Besides adherence capacities of substrates, the powder, liquid and plasticizer of some soft lining materials directly inhibited Candida growth. Thus, the results obtained here revealed that several factors within soft lining materials affected Candida growth and/or acid production.
Acrylic Resins↗
Interactions between denture lining material, protein pellicles and Candida albicans.
The interactions between pellicles derived from saliva, serum, mucin and lysozyme deposited on lining material (tissue conditioner) and Candida albicans were investigated by monitoring pH changes associated with protein-free and protein-coated lining material and by ultrastructural observations of yeast colonization. No significant differences in pH reduction between culture media in contact with the protein-free, control lining materials and those coated with saliva, serum or mucin were observed after 120 h of incubation. However, scanning electron microscopy revealed that much greater numbers of the yeasts colonized the saliva- or serum-coated lining material than the lysozyme-, mucin-coated or control material. Hyphal invasion was observed in saliva-coated lining material. These results suggested that denture pellicle derived from saliva and/or serum may potentiate candidal colonization of denture lining materials.
Adhesiveness↗
Heating system with a lens applicator for 430 MHz microwave hyperthermia.
To attain deep and localized heating for hyperthermic treatment of cancers, metal plate lens applicators that can converge microwave electromagnetic (EM) energy in the lossy medium such as human muscle with a computer-controlled heating system have been developed. This paper describes a system operating at 430 MHz. Results of an electric-field distribution calculation and a heating experiment made on a saline solution phantom show that the maximum heating depth is over 60 mm using the lens applicator, which is twice as deep as that obtained with a conventional waveguide applicator. The experimental results agree well with the theoretical ones. A computer-controlled heating system has been developed using the applicator. Experimental results show that fluctuations in temperature at locations in the heating region of the saline phantom were maintained within +/- 0.3 degrees C of the present temperatures. These results indicate that the system can be used for the clinical hyperthermia treatment of cancer.
Biomedical Engineering↗
Heating characteristics of a 430 MHz microwave heating system with a lens applicator in phantoms and miniature pigs.
Heating experiments on phantoms and miniature pigs were performed using two types of lens applicator and a conventional waveguide applicator fed by a 430 MHz microwave heating system (HTS-100, manufactured by Tokyo Keiki Co., Ltd). Temperature distributions in agar phantoms and miniature pigs were measured at regular intervals during heating. The following results were thus obtained: (1) The effective heating depth varied with the focal length, showing the lens effect. (2) Using a four-aperture lens applicator in miniature pigs, a heating depth of 6 cm was obtained. This almost doubles the depth of conventional waveguide applicator. The heating area was 12 X 6 cm at the depth of 4 cm. (3) Dielectric properties of the buttocks of the miniature pig were virtually identical to those of the agar phantom containing 0.35% NaCl and 0.05% NaN3.
Animals↗
Research and development of hyperthermia machines for present and future clinical needs.
This article describes the clinical problems encountered with the use of hyperthermia equipment and the requisites in the development of more advanced systems. A summary of the trends in the development of hyperthermia equipment is presented. In addition, a description from the physical point of view is included for the design of new applicators for deep heating.
Electrodes↗