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Biomedical subjects

Y Odaka

Publications and source records attributed to Y Odaka.

28 records · Page 2Linked to original sources
PubMed1988

[Hyperfunctioning follicular carcinoma of the thyroid. A case report].

A 76-year-old female patient with a large neck lump of 15-year duration, was accompanied by palpitation and tremor. The lump was 9 x 5cm in size and the lower half of it was not palpable because the lower pole was located in the mediastinum. Physical examination revealed two enlarged lymph nodes in the right supraclavicular area. Chest X-ray film showed a coin lesion in the right lung that seemed to be a metastasis. The patient was apparently thyrotoxic with elevated serum concentrations of 15.7 micrograms/dl thyroxin and 359 ng/dl triiodothyronine. A neck scintigraphy using 123Iodine showed a thyroid hot nodule in accordance with this lesion. A total thyroidectomy with a modified neck dissection was carried out. This was followed by 131Iodine therapy. Specimen of the primary lesion weighed 147 g. Pathology of this tumor was follicular carcinoma of the thyroid. The patient was doing well 14 months after surgery. In the literature, three cases of similar hyperfunctioning thyroid carcinoma have been reported, all of which had a large primary lesion. The histological features proved to be of follicular or papillofollicular type. The treatment in these cases was administration of an antithyroid drug followed by surgical removal.

Adenocarcinoma↗
PubMed1987

A resuscitation puzzle: acute acquired methemoglobinemia.

We treated a 32-day-old baby suffering acute acquired methemoglobinemia induced by topical application of aniline cocaine. Although acute acquired methemoglobinemia with severe cyanosis and distress is potentially fatal, this rare syndrome is easily curable if it is correctly diagnosed.

Anesthetics, Local↗
PubMed1983

Simultaneous determination of tegafur and 5-fluorouracil in serum by GLC using nitrogen-sensitive detection.

A sensitive assay of both tegafur (I) and 5-fluorouracil (5-FU) using GLC with a nitrogen-phosphorus-sensitive detector is described. The drugs were extracted from rabbit serum with ethyl acetate and methylated with diazomethane. Linearity was obtained over the concentration ranges of 3.13-200 micrograms/ml for I and 0.0313-2 micrograms/ml and 10-50 ng/ml for 5-FU. The detection limits of I and 5-FU in serum were 50 and 8 ng/ml, respectively. The serum concentrations of the drugs determined by the present method closely agreed with those obtained by spectrophotometry for I and microbial assay for 5-FU.

Animals↗
PubMed1982

Transport of L-cysteine and reduced glutathione through biological membranes.

Comparative studies were carried out on in vivo and in situ absorption in rats and in vitro uptake by red cells of L-cysteine (CySH) and reduced glutathione (GSH). After oral administration of CySH, the plasma and liver CySH levels and liver GSH level significantly increased, but the plasma GSH level did not. In contrast to the results with CySH, when GSH given orally at a dose equivalent to that of CySH either on a weight or molar base, no increase in the levels of GSH was observed at either dose level. In a rat small intestine recirculation system in situ, CySH added to the recirculation perfusate disappeared progressively with time from the perfusate, indicating that transportation occurred across the intestinal wall, but with GSH such disappearance was not observed. CySH was taken up well by rabbit erythrocytes in vitro, but GSH was not. It was concluded, therefore, that CySH passes through biological membranes and serves as a good source of SH groups, whereas GSH is ineffective when given orally because of its poor absorption from the digestive tract and/or poor ability to permeate through the membrane.

Animals↗
PubMed1975

Studies on the biochemical action of ginseng saponin. I. Purification from ginseng extract of the active component stimulating serum protein biosynthesis.

Systematic isolation and purification of the biologically active component of ginseng extract were followed by observing the incorporation of labeled leucine into serum protein at 6 hr after a single intraperitoneal injection in a mouse. Ginseng saponin mixture (fraction 5) exhibited high activity for such incorporation. Seven saponins were isolated from fraction 5 by means of preparative TLC, and assayed. Administration of all these saponins (ginsenoside-Rb2, Rc, Rc2, Rd, Re, and Rg1)except for ginsenoside-Rb1, caused an increase of leucine incorporation over that in control animals. The incorporation rate was directly proportional to the dose in the case of ginsenoside-Rd, which had the highest activity. The increase specific radio-activity of serum protein was not due to a decrease in the pool size of free amino acids in the liver. It was conclusively shown that the active component stimulating serum protein biosynthesis is saponin.

Animals↗