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Biomedical subjects

Y Pecau

Publications and source records attributed to Y Pecau.

At least 19 recordsLinked to original sources
PubMed1997

[Tuberculous pneumopathy in the course of cystic fibrosis].

BACKGROUND: Tuberculosis is rarely seen in patients with cystic fibrosis. CASE REPORT: A 14-year old female adolescent, regularly followed for a well-tolerated form of cystic fibrosis, developed an acute respiratory infection with consolidation of the left inferior lobe, and no response to the usual antibiotic treatment of cystic fibrosis. Mycobacterium tuberculosis was found in aspirate by fibroscopy, on Loewenstein medium. No familial or social infection contact were identified. Antituberculous chemotherapy with three drugs brought about a prompt improvement of sytemic signs, weight gain, resolution of pulmonary foci and sedation of biological findings referable to inflammation. CONCLUSION: This case report reminds us that tuberculosis may occur in cystic fibrosis patients. Loewenstein cultures should routinely be made when faced with an unexplainable worsening of the condition.

Adolescent↗
PubMed1993

Liver cirrhosis in cystic fibrosis--therapeutic implications and long term follow up.

Experience gained from liver studies in 450 patients with cystic fibrosis, seen in a 38 year period from 1964 to 1992, is surveyed. Of these, 31 (7%) showed findings that indicated multilobular cirrhosis. There was a slight but not significant male predominance: 19 males against 12 females. Liver disease had its onset during childhood in most cases. The natural course of liver disease and of cirrhosis is protracted. All patients were routinely evaluated by way of: (i) clinical examination, (ii) biochemical studies and specifically estimation of transaminases and gamma glutamyltransferase, and (iii) liver imaging, ultrasonography, and computed tomography. The study aimed to detect early liver disease, that is multilobular cirrhosis and its complications, with a view to optimal introduction of treatment with ursodeoxycholic acid as this drug shows promise for preventing or stabilising the cirrhotic process. Effects of surgical treatment on portal hypertension are surveyed. These include portacaval shunting, partial splenectomy (considered the procedure of choice), liver transplant in the event of liver failure, or a triple transplant (liver, lungs, and heart) if necessary. One triple transplant was successfully performed in a boy of 10 years with a 2 year follow up.

Adolescent↗
PubMed1986

[Anomalies of the sperm, vas deferens and epididymis in cystic fibrosis].

Ten adult patients with cystic fibrosis presented with lesions of the genital tract at different levels. Bilateral lesions of the vas deferens were constant and resulted in azoospermia in 9 cases; the fertile patient had a son. The sperm of these 10 patients was compared to that of 5 adult controls. A decrease in sperm volume, pH and fructose and an increase in citric acid and acid phosphatase were observed in the cystic fibrosis group. It is concluded that all subjects with azoospermia should be investigated for cystic fibrosis by means of the sweat test.

Adolescent↗
PubMed1981

[Successive courses of intensive therapy in cystic fibrosis (author's transl)].

Twenty-four patients aged from 3 to 30 years and suffering from advanced cystic fibrosis received several courses of intensive antibiotic therapy combined with prolonged respiratory physiotherapy with postural drainage. Antibiotics included carbenicillin 500 mg/kg/day and aminoglycosides in high dosage (6 mg/kg/day). These treatments were administered to prevent aggravation of chronic bronchitis and to suppress acute exacerbations. Tolerance was satisfactory, and all patients felt better, at least during the first courses. Improvement was also observed in the main respiratory function parameters. In a total of 95 courses only two side-effects (severe dizziness and giant urticaria) were recorded. Intensive courses of combined antibiotic therapy associated with physiotherapy constitute a new way of treating severe, progressive cystic fibrosis. The patients are made comfortable, and their survival time is increased by several years.

Adolescent↗
PubMed1980

[Alpha-1-antitrypsin and cystic fibrosis (author's transl)].

A methodical study of the alpha-1-antitrypsin serum level and the Pi type in 69 CF children, 156 CF heterozygote parents and 200 blood donors from Paris, has been made. Although the PiZ allele frequency was found to be higher in the CF population, especially in fathers, than in the reference population, the difference is not statistically relevant. Therefore there does not seem to be a relation between cystic fibrosis and the Pi alleles system.

Adolescent↗
PubMed1975

Additional data on hepatic function tests in cystic fibrosis.

Fifty cystic fibrosis (CF) patients, of whom 9 had multilobular cirrhosis, were observed regularly for a period of 3 years and various liver function tests, indicating cytolysis, cholestasis and cellular insufficiency were performed. Immunoglobulin and prothrombin were assayed. In 9 patients with cirrhosis, the tests were generally abnormal. Two distinct biochemical patterns of cirrhosis were distinguished, one clearly cholestatic and the other of a more cellular type. The distinction was made on the basis of the IgA : Transferrin ratio and of gamma-glutamyl-transpeptidase levels. In the non-cirrhotic patients, a temporary increase of cytolysis and cholestasis was observed in 50% of the cases.

Adolescent↗
PubMed1975

[Coprologic anomaly in mucoviscidosis. Presence of albumin in low concentration in the feces].

With an immunological technique, presence of albumin was searched in the stools of 47 patients with cystic fibrosis and 54 controls. Albumin was found in 93% of cystic fibrosis, at a mean level of 90 mg/100 g of fresh stools. The test was negative in the 54 healthy controls. It was positive in one case of congenita IgA deficiency and in one untreated case of Hirschprung's disease. When found in the stools, albumin may give a useful additional diagnostic element.

Adolescent↗