PubMed Health⌕ Search

Biomedical subjects

Y Q Bai

Publications and source records attributed to Y Q Bai.

7 recordsLinked to original sources
PubMed2001

[Research progress of methods of heart rate variability analysis].

One of the hotspots in the analysis of ECG is heart rate variability (HRV). In the present, the method mostly used for the analysis of HRV signal is linear analysis, and nonlinear analysis seldom used. Research progress of several methods of HRV analysis is presented. Principles and characteristics of using nonlinear analysis for the study of HRV are analyzed in detail. Fractal dimension, complexity and approximate entropy are discussed.

Electrocardiography↗
PubMed1999

Predominant germ-line mutation of the hMSH2 gene in Japanese hereditary non-polyposis colorectal cancer kindreds.

By means of PCR-SSCP and direct sequencing, we detected 12 germ-line mutations of hMSH2 or hMLH1 in 37 Japanese hereditary non-polyposis colorectal cancer (HNPCC) kindreds, of whom 15 satisfied the Amsterdam and 22 the Japanese criteria. The germ-line mutation detection rate of hMSH2 was much higher than that of hMLH1 (11/37 vs. 1/37). The total mutation detection rate of hMSH2 and hMLH1 in the Amsterdam criteria group was significantly higher than that in the Japanese criteria group (9/15 vs. 3/22). Furthermore, the mean age of the HNPCC patients in the mutation-positive group was lower than that in the mutation-negative one; the rates of both vertical transmission and multiplicity of tumors in the mutation-positive group were higher than those in the mutation-negative one. In addition, the number of patients with microsatellite instability-positive cancers in the mutation-positive group was higher than that in the mutation-negative one. Our results suggest firstly that the hMSH2 gene plays a much more important role than hMLH1 in the carcinogenesis of Japanese HNPCC patients, secondly that the rate of hMSH2 and hMLH1 mutations is high in the kindreds satisfying the Amsterdam criteria and thirdly that both the clinical phenotypes (early onset, vertical transmission and multiplicity of tumors) and the microsatellite instability status are important for the genetic screening of HNPCC.

Colorectal Neoplasms, Hereditary Nonpolyposis↗
PubMed1999

[Psychological issues in manned spaceflight].

As the duration of manned spaceflight becomes longer and as crews become more heterogeneous, psychological and interpersonal factors will be more important in affecting the safety of crew and flight mission. In space environment there are four types of stressors: physical, physiological, psychological and interpersonal. Psychological issues include "Asthenia", alteration in time sense, transcendent experiences, sleep problem, career motivation, psychosomatic symptoms and psychiatric issues. Interpersonal issues include interpersonal tension, interpersonal relationships decreased cohesiveness and deprivation, displacement [correction of dispiacement] of anger to outside personnel over time.

Adaptation, Psychological↗
PubMed1992

[Observation on the occurrence of lung cancer and changes of pulmonary bronchioles and arterioles in the smokers].

We studied 600 lung specimens microscopically. Among them, 362 were males, smokers accounted for 304 cases. 236 cases were lung carcinoma were found, 72% were smokers. Among the 236 cases, 110 cases of squamous carcinoma. The smokers were 6.8 times more than the nonsmokers, 22 cases were small cell carcinoma, the smokers were 4.4 times more than nonsmokers. 84 cases were as adenocarcinoma, the number of the smokers were as similar as that of nonsmokers. In cases with smoking history of less than 10 years, the thickness of arterioles wall were similar to that of nonsmokers. The thickness of arteriole wall increased as the duration of smoking history increased. (12%-22.4% in every 10 years).

Adenocarcinoma↗