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Biomedical subjects

Y Romem

Publications and source records attributed to Y Romem.

23 records · Page 2Linked to original sources
PubMed1983

Overdose of booster tetanus toxoid given in error: a clinical study.

16 reserve soldiers received an overdose of tetanus toxoid vaccine (5 ml instead of 0.5 ml) in error. We assessed the incidence and severity of adverse reactions and determined tetanus antibody titer immediately and after 5 days, 1 month and 1 year, and compared it with the titers in a control group of 20 soldiers. The incidence and severity of reactions was significantly higher in the overdose group. The mean tetanus antibody titer rose to similar levels in both groups after 1 month (153.75 +/- 82.5 IU/ml and 62.02 +/- 42.15 IU/ml respectively) but decreased sharply after 1 year in the overdose group.

Adult↗
PubMed1982

March myoglobinemia: a hazard to renal function.

Serum muscle enzyme levels, myoglobin levels, and renal function were measured in a group of 20 army recruits who had volunteered for a prolonged period of primary, specially designed, gradual training. Blood samples were taken before training and before and after each hike. Levels of serum myoglobin, creatinine phosphokinase, lactic dehydrogenase, and SGOT indicated muscle injury. Levels of urea creatinine, and uric acid and creatinine clearance evaluated renal function. Substantial elevation of muscle enzyme levels and persistent myoglobinemia were observed throughout the study. A highly significant decrease in creatinine clearance was demonstrated. After the last hike, the mean creatinine clearance was 70.41 mL/min, which is notably lower than the value at the beginning of the study. Prolonged physical exercise induces muscular damage, as evidenced by a rise in myoglobin and enzyme levels. Continuous muscle injury induces persistent myoglobinemia, a probable hazard to renal function.

Acute Kidney Injury↗
PubMed1980

Uterine perforation during curettage: perforation rates and postperforation management.

Over a period of eight years, 13,344 consecutive patients underwent curettage in our hospital for various indications. Uterine perforation occurred in 22 (0.16%) of them. An additional seven patients were admitted with existing uterine perforation. The most common site of perforation was the uterine fundus and the instrument most often involved was a sharp curette. The perforation rates in curettage performed for postpartum hemorrhage and intrauterine adhesions were relatively high (5.1 and 1.8%, respectively); the rates in those for elective abortion and postmenopausal bleeding were intermediate (0.4 and 0.2%, respectively); and in those performed for other indications, the rate was very low (less than or equal to 0.06%). After uterine perforation occurred 15 patients (51.7%) were managed by observation only and the course was uneventful. In 10 patients (34.5%), exploratory laparotomy was performed; in three of them, no active bleeding organ injury was found. Judicious use of laparoscopy after uterine perforation allows proper selection of patients for further surgery.

Curettage↗
PubMedDate not supplied

Relatively reduced values of plasma alpha-fetoprotein at early second trimester of pregnancies with hypertensive disorders.

Hypertensive disorders during pregnancy implicate placental pathologic conditions, which may interfere with the normal passage of alpha-fetoprotein (AFP) to the maternal blood. We compared the levels of maternal serum (MS) in early second trimester of pregnancies complicated by hypertensive disorders with those of matched controls. The distribution in the study group of MS-AFP multiple of median values was significantly different from the distribution in the control group. Moreover, up to multiple of the median 1.00, the number of hypertensive patients was larger than the number of normotensive pregnant women. The mean level of multiples of the median in the study group was significantly lower than that of the control group (p value = 0.003, 95% confidence interval: -0.30, -0.05). In the analysis of the distinct types of hypertension, the difference remained significant for 85 women in the moderate hypertension subgroup (p value = 0.032, confidence interval: -0.34, -0.02) and was not significant for the severe hypertension subgroup of 22 women (p value = 0.24, 95% confidence interval: -0.57, 0.15) and chronic hypertension subgroup of women (p value = 0.52, 95% confidence interval: -0.44, 0.00). The trend was consistent in all the subgroups. Relatively low values of maternal serum AFP at early second trimester of pregnancies with hypertensive disorders may be a result of placental pathologic involvement and can help in the identification of the women at risk.

Adolescent↗