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Biomedical subjects

Y Rose

Publications and source records attributed to Y Rose.

17 recordsLinked to original sources
PubMed1999

Uninflected structure in familial language impairment: evidence from French.

We present the results of 20 French subjects with familial language impairment (FLI) on a linguistic battery task, with an emphasis on verb production. The results show strong qualitative differences between the verb production of FLI subjects and that of controls. Language-specific factors do not seem to determine the production of verbs in French FLI individuals. Rather, verb frequency and the inflectional status (uninflected vs. inflected) of the form seem to be determining factors in correct/incorrect production of a verb in a sentence context. The phonetic structure of French inflection provides additional arguments against the hypothesis of a processing deficit in FLI subjects. French tense morphemes are stressed and salient, and should therefore be produced without problems, according to the processing hypothesis. We found evidence contrary to this postulate. We therefore submit that the morphological deficit hypothesis is supported by the French data.

Adolescent↗
PubMed1998

Superoxide-mediated decomposition of biological S-nitrosothiols.

Incubation of S-nitrosocysteine or S-nitrosoglutathione (5-100 M) in the presence of a generator of superoxide (xanthine/xanthine oxidase) resulted in a time-dependent decomposition of S-nitrosothiols and accumulation of nitrite/nitrate in reaction mixtures. Quantitatively, the amounts of nitrite/nitrate represented >90% of nitrosonium equivalent of S-nitrosothiols degraded during the incubation. The reaction rates were unaffected by the presence catalase (1 unit/ml). Kinetic analysis showed that the degradation of S-nitrosothiols in the presence of superoxide proceeded at second order rate constants of 76,900 M-1 s-1 (S-nitrosocysteine) and 12,800 M-1 s-1 (S-nitrosoglutathione), respectively, with a stoichiometric ratio of 1 mol of S-nitrosothiol per 2 mol of superoxide. The findings provide the evidence for the involvement of superoxide in the metabolism of S-nitrosothiols. Furthermore, substantially slower reaction rates of superoxide with S-nitrosothiols relative to the reaction rate with NO are consistent with the contention that the transient formation of S-nitrosothiols in biological systems may protect NO from its rapid destruction by superoxide, thus enabling these compounds to serve as carriers or buffers of NO.

Catalase↗
PubMed1990

A home of your own? A guide to getting a mortgage.

High mortgage rates are regularly in the news at the moment, and many people are wary of deciding to buy property. However, with property prices depressed, there may be some bargains to be found, so the idea may be worth considering.

Economics, Nursing↗