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Biomedical subjects

Y Rosenbach

Publications and source records attributed to Y Rosenbach.

28 records · Page 2Linked to original sources
PubMed1985

Protein conservation by the immature intestine.

Uptake of intact macromolecules by the immature gut is a well-known phenomenon, but no information exists on the possibility that there is also increased protein loss in the intestinal lumen in preterm infants. We determined alpha-1-antitrypsin (A-1-AT) levels in fecal samples from 39 infants born after 27-41 weeks of gestation from birth up to 30 days of age. A-1-AT levels were elevated only in meconial stools, and low in nonmeconial stools, regardless of associated respiratory disorders, drug administration, and type of nutrition. This study shows that the immature gut has a mature pattern of protein conservation at least as early as after 29 weeks of gestation.

Feces↗
PubMed1984

Random fecal alpha 1-antitrypsin excretion in children with intestinal disorders.

Demonstration of excessive enteric protein loss traditionally required the use of labeled macromolecules and prolonged stool collection uncontaminated by urine. alpha 1-Antitrypsin (alpha 1-AT) clearance has recently been used for the demonstration of enteric protein loss, but controversy still exists about the value of determining alpha 1-AT concentration in random stool samples. We have measured alpha 1-AT excretion in random stool samples from children with various gastrointestinal (GI) tract disorders using an immune nephelometric method. Statistically significant elevations in alpha 1-AT concentrations were found in stools from patients with active celiac disease and confirmed PLE, while normal values were demonstrated in patients with irritable bowel and inactive celiac disease. We conclude that determination of alpha 1-AT concentration in random fecal samples is an easy, reproducible screening method for the demonstration of excessive enteric protein loss in various GI tract disorders.

Celiac Disease↗
PubMed1980

Gastrointestinal manifestations of Niemann-Pick disease.

3 infants wih the acute neuronopathic form of Niemann-Pick disease had prominent gastrointestinal manifestations. These included chronic diarrhea, malnutrition, failure to thrive, radiologic intestinal abnormalities, xylose malabsorption, abnormal liver function, and infiltration of the liver, lamina propria and autonomic ganglia by lipid-laden cells. Possible pathogenetic mechanisms are discussed, and it is suggested that gastrointestinal disturbances play a larger part in the clinical manifestations of Niemann-Pick disease than is usually appreciated.

Digestive System↗
PubMedDate not supplied

Cricopharyngeal dysfunction in childhood: treatment by dilatations.

A 3-year-old child with cricopharyngeal dysfunction is reported. Swallowing difficulties, nasal regurgitation, and gagging developed at 2 months of age. Repeated aspirations and over 40 episodes of pneumonia necessitating multiple hospitalizations occurred up to 2 years of age, along with pharyngeal pooling of saliva and inability to swallow solid food. Barium was held up at the cricopharyngeal level, and a prominent esophageal impression was seen at the same level. Symptoms were completely alleviated after two esophageal dilatations by mercury dilators, and the relief persisted for the 6 months of follow-up. The diagnosis of cricopharyngeal dysfunction is discussed, and the necessity for manometric studies, in the face of often misleading radiologic appearance, is emphasized. It is suggested that early use of esophageal dilatations might prevent prolonged morbidity and afford long-term symptomatic relief.

Child, Preschool↗