PubMed Health⌕ Search

Biomedical subjects

Y Shechter

Publications and source records attributed to Y Shechter.

132 records · Page 8Linked to original sources
PubMedDate not supplied

Insulin-like actions of vanadate are mediated in an insulin-receptor-independent manner via non-receptor protein tyrosine kinases and protein phosphotyrosine phosphatases.

Most or all mammalian cells contain vanadium at a concentration of 0.1-1.0 microM. The bulk of the vanadium in cells is probably in the reduced vanadyl (IV) form. Although this element is essential and should be present in the diet in minute quantities, no known physiological role for vanadium has been found thus far. In the years 1975-1980 the vanadate ion was shown to act as an efficient inhibitor of Na+,K(+)-ATPase and of other related phosphohydrolyzes as well. In 1980 it was observed that vanadate vanadyl, when added to intact rat adipocytes, mimics the biological actions of insulin in stimulating hexose uptake and glucose oxidation. This initiated a long, currently active, field of research among basic scientists and diabetologists. Several of the aspects studied are reviewed here.

Adipocytes↗
PubMedDate not supplied

A second case of hemolytic disease of the newborn due to anti-Jsa.

A second case of hemolytic disease of the newborn caused by Jsa sensitization is reported. The child was mildly affected and transfusions were not required. The mother and father are Arabs. Jsa was present in the father, the baby in question, and a sibling. In addition, the Fy gene was present in both mother and father, and in two of their three children.

Blood Group Antigens↗
PubMedDate not supplied

Effect of tobacco smoke on the metabolism of rat lung.

The authors have studied the effect of cigarette smoke on the uptake and metabolism of 3H-palmitate, 3H-leucine, U14C-glucose and 14C-glucosamine utilizing slices of rat lung. The rats were exposed daily for 30 days to University of Kentucky research cigarettes (brands 1A1 or 1R1) in the Walton smoking machine. One group of rats served as intact controls and another were introduced into the machine, but were not exposed to smoke. All animals were weight-matched at the beginning of the experiment (180 +/- 5 g); machine control rats gained 25% less weight, 1A1-exposed rats 40%; and 1R1-exposed rats 26-40% less than controls. Exposure to tobacco smoke had no effect on palmitate uptake and synthesis of phospholipids; exposure to 1A1 cigarettes caused a 25% increase in 14CO2 production and a 30% higher incorporation of glucose into lipids. Exposure to 1R1 cigarettes had no effect on glucose metabolism. Protein synthesis was 30% lower in 1R1-exposed rats and glycoprotein synthesis increased two-fold in both 1A1 and 1R1 exposed rats.

Animals↗