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Biomedical subjects

Y Sherman

Publications and source records attributed to Y Sherman.

49 records · Page 3Linked to original sources
PubMed1987

Cardiovascular pathology induced by passive transfer of splenic cells from syngeneic rats treated with T-2 toxin.

Mononuclear cells were separated from spleens and lymph nodes of Lewis rats treated 5 weeks previously with repeated small doses of T-2 toxin or solvent only. The cells from each site were then injected intraperitoneally into 4 groups of syngeneic Lewis rats. The animals injected with spleen cells from T-2 toxin-treated donors developed marked cardiovascular changes which were similar to those due to T-2 toxin itself. Rats injected with lymph node cells as well as those given each kind of cell from solvent-treated donors showed only occasional mild vascular changes. The changes seen after splenic cell transfer may be due to superinduction of interleukin 2 by T-2 toxin.

Animals↗
PubMed1984

Generalized lymphadenitis following B.C.G. vaccination in an immunocompetent 12-year-old boy.

An immunocompetent, healthy 12-year-old boy was presented with generalized large lymphadenopathy in the left side of the body, 1 month after a BCG vaccination with a regular dose. A Mantoux test before vaccination was negative. Histological and bacteriological findings from the largest lymph node biopsy revealed BCG'itis. The patient recovered spontaneously after 7 months. He was confirmed as being immunocompetent by normal serum immunoglobulin levels, normal B and T cell function tests, and a conversion of Mantoux test. BCG infections including lymphadenitis are rare and have been described hitherto mainly in infants, in immune deficient patients, or related to overdose. Such a complication must be taken into consideration when dealing with lymphadenopathy in healthy school-age children, who now undergo BCG vaccinations in many countries.

B-Lymphocytes↗
PubMed1984

T-2 toxin effect on bacterial infection and leukocyte functions.

The effects of T-2 toxin on bacterial infection and leukocyte function and structure were examined in vivo and in vitro. Rats were innoculated with staphylococci after pretreatment with or without T-2 toxin. The T-2 pretreated rats failed to mount a cellular response to the bacteria. Blood and bone marrow cells were markedly suppressed by the T-2 toxin, the myeloid series being the most affected. In vitro studies with human leukocytes showed that small, nonkilling doses of T-2 toxin inhibited chemotaxis, chemiluminescence stimulated by bacteria, and phagocytosis of bacteria. It was concluded that this inhibition may contribute towards sepsis and rapid onset of death in T-2 toxin poisoning.

Animals↗
PubMed1984

A case of triple primary gynecological malignancy.

A 71-year-old woman was admitted due to postmenopausal vaginal bleeding. During a routine physical examination, a tumor in the left breast was discovered. A fractionated curettage was performed. Endometrial adenocarcinoma and squamous cell carcinoma of the cervix was found on histological examination. A total hysterectomy was performed. Subsequently, a breast biopsy was performed which revealed an infiltrating duct carcinoma of the breast and a mastectomy was performed. Triple gynecological cancer is discussed.

Adenocarcinoma↗
PubMed1984

Granulomatous prostatitis with vasculitis. A sequel to transurethral prostatic resection.

An 80-year-old patient suffering from prostatism underwent repeated transurethral prostatic resection. Histologic examination of the prostatic tissue that was removed at the time of the second operation disclosed a granuloma with fibrinoid necrosis combined with necrotizing vasculitis. Only four cases of granulomatous prostatitis and vasculitis have been reported in the literature:two were generalized vasculitis, while in the two other instances, the vasculitis was confined to the prostate. We report an additional case of granulomatous prostatitis combined with vasculitis localized in the prostate.

Aged↗
PubMed1983

Avoidable factors in child death.

There were 131 deaths among children aged between birth and 14 years during a period of 18 months in one inner London area health authority. One hundred children died in hospital, 23 at home, and 8 elsewhere. Thirty three died of congenital, 46 of perinatal, and 34 of other medical causes. There were 18 violent deaths--16 among children over 1 year of age. Medical and social information, collected from analysis of records and interview with those involved, was considered by a review panel and the following conclusions were drawn: there was scope for prevention of congenital disease or malformation in only one of 33 cases; with routine pathological investigation the cause of death in postperinatal infancy was usually unclear--more detailed pathological investigation should be routinely available for the investigation of deaths in the first year of life; there were possible management failures in four of 8 non-malignant medical deaths in older children; malignant disease was promptly diagnosed; fatal accidents were almost entirely restricted to the children of families under marked psychosocial stress; and there was some evidence of faulty communication between health agencies and of the inappropriate routing of emergency admissions.

Accidents↗
PubMed1983

T-2 toxin-induced pathology in the hearts of rats.

T-2 toxin is the major lethal component of several Fusarium fungi implicated in diseases of man and animals. We report here on the histological and ultrastructural changes in hearts of rats given i.p. single large or repeated small doses of T-2 toxin. One, 2 and 3 days after a single large dose, there were lesions in most hearts. They consisted of interstitial oedema, focal cellularity and damage to single or groups of myocytes. The small intramural coronaries were constricted, swollen and sometimes disrupted. After 7 days, most of the changes subsided. In rats killed 1 or 2 months after the last of 10 daily injections of T-2 toxin, cardiomyopathy-like changes were seen with hypertrophy, focal fibrosis and abundant cellularity especially in the subendocardial regions of the left ventricle. The findings, although non-specific, indicate that T-2 toxin is cardiotoxic.

Animals↗
PubMed1983

Duplication of the gallbladder associated with childhood obstructive biliary disease and biliary cirrhosis.

A 4-yr-old girl presented with recurrent attacks of abdominal pain, vomiting, fever, and jaundice, progressing to biliary cirrhosis. The diagnosis of duplication of the gallbladder was established by transhepatic cholangiography. Clinical recovery and histologic improvement followed removal of the gallbladders. In every case of obstructive biliary disease or biliary cirrhosis in childhood, no effort should be spared in searching for a malformation of the biliary system.

Child, Preschool↗