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Biomedical subjects

Y Siegman-Igra

Publications and source records attributed to Y Siegman-Igra.

At least 55 records · Page 3Linked to original sources
PubMed1987

Tuberculosis in a general hospital: high incidence of extrapulmonary disease.

Twenty six patients with tuberculosis were admitted between 1979 and 1982 to the Tel Aviv Medical Center. Most were immigrants from Eastern Europe. In contrast to previous studies, patients were relatively young (mean age 57 years) and lacked predisposing medical illness. Eighteen (69%) had extrapulmonary infections, half of which involved the genitourinary tract. Two instances of miliary tuberculosis were diagnosed at autopsy.

Adult↗
PubMed1987

Visceral leishmaniasis presenting as fever of unknown origin.

A 41-year-old male presented with a prolonged febrile disease with marked splenomegaly. Bone marrow and liver biopsy smears and cultures for Leishmania were repeatedly negative and there was no hyperglobulinemia. Leishmania parasites were ultimately demonstrated only in the spleen at laparotomy, performed because of severe pancytopenia. The epidemiology of leishmaniasis in Israel is reviewed.

Adult↗
PubMed1986

Should potted plants be removed from hospital wards?

Seventy-nine isolates of Gram-negative bacilli were recovered from 29 potted plants on six surgical wards. The distribution of bacterial species and antibiotic susceptibility patterns revealed no correlation with 235 isolates from nearby patients during the study period. Potted plants do not appear to constitute a bacteriological hazard in the hospital.

Bacteria, Aerobic↗
PubMed1986

Pneumococcaemia as a presenting sign in 3 cases of multiple myeloma.

Multiple myeloma was diagnosed in 3 patients following episodes of pneumococcaemia associated with neutropenia and decreased serum concentration of normal immunoglobulins. Severe pneumococcal infection is commonly encountered during the course of multiple myeloma, but has not been stressed as a presenting feature of the disease.

Aged↗
PubMed1986

Invasive pneumococcal infection in Israel. Review of 90 cases.

90 cases of invasive pneumococcal infection hospitalized during the period 1975-1984 were reviewed. The organism was recovered from blood, cerebrospinal fluid or other normally sterile body fluids. 40 of the patients were adults, most of whom had pneumonia, and 50 were children who had pneumonia, primary bacteremia or meningitis. 90% of the adults and 14% of the children had underlying conditions. Nosocomial infection was remarkably more common among adults (25%), than among children (2%). Mortality was similar to that reported by others: 37% for adults and 10% for children. The most important predictive factors for fatal outcome were: old age (greater than 80), meningeal infection, presence of malignancy or chronic lung disease, and failure to mount leucocytosis. 13% of the strains were moderately resistant to penicillin.

Adolescent↗
PubMed1985

An 'outbreak' of pulmonary pseudoinfection by Serratia marcescens.

The recovery of multiple isolates of Serratia marcescens from bronchial lavage specimens was traced to contaminated fibreoptic bronchoscopes. Four patients were involved and none became infected. Awareness of a cluster of serratia cultures and immediate investigation and institution of control measures may have prevented the occurrence of true infections.

Aged↗
PubMed1985

Intravenous acyclovir for herpesvirus in immunocompromised patients.

Severe herpesvirus infections in 18 immunocompromised patients (25 episodes) were treated with i.v. acyclovir. Six patients had 13 episodes of mucocutaneous herpes simplex infections, eight children had varicella, three patients had generalized zoster, and one patient had cytomegalovirus pneumonia. No patient died from infections. In 18 episodes treatment with acyclovir produced a beneficial effect, in 5 episodes acyclovir was probably beneficial, and in 2 patients the effect could not be evaluated. No serious side effects could be definitely attributed to acyclovir administration. These data support the previous experience that i.v. acyclovir may be useful in the treatment of herpesvirus infections in immunocompromised patients.

Acyclovir↗
PubMed1985

Septicemia with two distinct strains of Staphylococcus aureus and dwarf variants of both.

A patient with erythema multiforme developed septicemia with two strains of Staphylococcus aureus. Six blood cultures, obtained during 14 days, yielded a mixture of both strains. The strains differed in the ability to hemolyze human erythrocytes, in the production of beta-lactamase and in the susceptibility to antibiotics and bacteriophages. Following therapy with gentamicin, a Dwarf colony variant auxotrophic for vitamin K, tryptophan and p-aminobenzoic acid appeared in some of the blood cultures. This variant was apparently derived from one of the offending strains (phage Type 55/71). From other blood cultures, a different type of Dwarf colony variant was obtained; this variant was of the same phage type as the other offending S. aureus strain (Type 85). The metabolic deficiencies of this strain were not unraveled. Both events, the double infection with distinct S. aureus strains, and the emergence of Dwarf variants during antibiotic therapy, are unusual in clinical practice, and will be detected only if laboratory staff pays particular attention to the possible occurrence of such events.

Aged↗
PubMed1984

Endocarditis caused by Actinobacillus actinomycetemcomitans.

The first two cases of Actinobacillus actinomycetemcomitans endocarditis in Israel are reported. One involved a 67 year old woman with mitral insufficiency and the other, a 48 year old alcoholic male with bioprosthetic mitral valve. The organism grew in three of seven and seven of fourteen blood culture specimens, taken during the first two or three days of hospitalization respectively. Blood cultures became positive after incubation for seven days. The first patient recovered after therapy with penicillin and an aminoglycoside, and the second one is still being treated. Previously described cases of Actinobacillus actinomycetemcomitans endocarditis are reviewed.

Actinobacillus Infections↗
PubMed1984

Herpes zoster encephalitis: isolation of virus from cerebrospinal fluid.

Two elderly female patients developed symptoms and signs of encephalitis, coincident with a cutaneous zoster eruption ("shingles"). One recovered slowly with mild residual motor dysfunction, and the other died. Varicella-zoster virus was isolated from the cerebrospinal fluid of the two patients. Review of the literature revealed only eight previously described patients in whom herpes zoster virus was isolated from the cerebrospinal fluid.

Aged↗
PubMed1984

Histiocytic hemophagocytosis in miliary tuberculosis.

The signs, symptoms, and bone marrow findings of the recently described virus-associated hemophagocytic syndrome was seen in a patient we treated. The manifestations of this syndrome may not be specific to viral infections and may possibly occur in other infectious processes. Autopsy findings in the present case showed it to be associated with disseminated miliary tuberculosis. Concomitant viral infection was excluded. To our knowledge, only one similar patient has previously been described.

Aged↗
PubMed1983

Group VE-1 septicemia.

A severely immunocompromised patient developed septicemia while under treatment for pancreatitis. An organism isolated from three separate blood cultures was identified as CDC group VE-1. The biochemical characteristics, taxonomy, and antibiotic sensitivity of this organism are presented.

Abscess↗