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Biomedical subjects

Y Suezawa

Publications and source records attributed to Y Suezawa.

At least 19 recordsLinked to original sources
PubMed1989

Does percutaneous nucleotomy with discoscopy replace conventional discectomy? Eight years of experience and results in treatment of herniated lumbar disc.

Percutaneous nucleotomy was first described in 1975 by Hijikata in Japan. In 1979 the present authors adopted this method for the treatment of lumbar disc herniation and modified Hijikata's original instruments. Since 1982 additional intradiscal optical control has been included by means of an adapted arthroscopic kit for more accurate and effective removal of the nucleus pulposus under direct view. This procedure is called discoscopy. Between 1979 and late 1987, the method was applied to 109 patients with lumbar disc herniation. The indications included lumbar sciatica that (1) was resistant to conservative treatment and (2) in which myelography and/or examination by computed tomography proved a disc protrusion without dislocation in the spinal canal. The level most affected was L4-L5. Major operative complications encountered were one vascular lesion and two cases of secondary spondylodiscitis. Clinical results in patients with other additional causes of sciatica, such as spondylolisthesis or relapse of disc herniation, were nearly as favorable as in isolated first-time disc herniation. The overall success rate was 72.5% (79/109 patients).

Adult↗
PubMed1986

Percutaneous nucleotomy. An alternative to spinal surgery.

As an alternative to the well-established surgical procedures for the treatment of disk herniation, percutaneous nucleotomy has proved to be very satisfactory. In several cases this approach has brought complete relief to the patient without sacrifice of bone and without causing soft tissue damage as would have been inevitable with the usual surgical methods. Percutaneous nucleotomy is also a true alternative to chemical nucleolysis when leakage of contrast agent into the spinal canal has already been observed during diskography. Furthermore, this method avoids disagreeable complications encountered in chemical nucleotomy, for example, anaphylactic shock or the escape of the nucleolytic agent into the spinal canal. The method basically consists of removing the nucleus pulposus (or a major part of it) by means of a forceps that is introduced to the site through a cannula. In this manner a reduction of volume of the disk is achieved. The procedure can easily be carried out under local anesthesia. This method should be avoided in the case of prolapse within the spinal canal and especially when displacement beyond the level of the disk has occurred. In the period between 1979 and 1985 we carried out percutaneous nucleotomies in 51 patients with herniation mostly combined with a narrow spinal canal or spondylolisthesis. The clinical results from 32 of 51 patients can be assessed as very good, good, or satisfactory. We consider the proportion of patients showing good clinical results to be high, bearing in mind that the indication was not just disk herniation alone but, in most cases, combined with other lumbar pathologies as well.

Adult↗
PubMed1986

Lumbar and thoracic spinal fusion with transpedicular fixation (including a novel distraction and compression device). A preliminary report.

Experience with three different systems of transpedicular fixation in fusion of the lumbar and thoracic spine over 4 years is reported. The Roy-Camille plates, Louis plates, and the Balgrist turn-buckle arrangement are compared. The Balgrist device allows both extension and compression, and affords better stability. Far better clinical results were obtained with transpedicular fixation in general than with the Harrington method.

Adolescent↗
PubMed1986

Transdiscoscopic percutaneous nucleotomy in disk herniation.

The authors describe their use of percutaneous nucleotomy in the treatment of lumbar disk herniation. They report on the first 40 patients so treated at the Department of Orthopaedic Surgery, University of Zurich, Switzerland. They note the procedure offers good possibilities and that in some cases, in combination with discoscopy (arthroscopy), has several advantages over conventional surgical techniques.

Adult↗
PubMed1983

Modification of microsomal lipid composition and electron transport enzyme activities in isovalerate-supplemented cells of novel Tetrahymena ISO.

Tetrahymena ISO cells, which have an unusually high level of iso odd-numbered fatty acids, were grown medium supplemented with various concentrations of isovalerate. There was a marked increase in the total proportion of iso odd-numbered fatty acids in supplemented whole cells (28.9 leads to 70.3%) and microsomes (37.7 leads to 84%), with a corresponding decrease in normal fatty acids, although no significant alteration of phospholipid composition was observed during 11 hr isovalerate-supplementation. Microsomal palmitoyl-CoA and stearoyl-CoA desaturase activities in isovalerate-supplemented cells decreased by 45.7% and 30.6% during 11 hr, respectively. NADH-cytochrome c reductase and NADH-ferricyanide reductase activities as well as the content of cytochrome b560ms, which is similar to mammalian microsomal cytochrome b5, were reduced in microsomes from 11 hr-supplemented cells, whereas NADPH-cytochrome c reductase activity was constant. It is suggested that the alteration of the cross-sectional area of lipid molecules in the bilayer, which results from the replacement of normal fatty acids with iso- 15:0 and iso- 17:1, would result in the decline of palmitoyl- and stearoyl-CoA desaturation in the isovalerate-supplemented cells, in order to maintain membrane fluidity at a functional level.

Animals↗
PubMed1981

A comparison of the long term results of three types of posterior fusion of the lumbar spine for spondylolisthesis.

Between 1923 and 1976, 312 posterior spinal fusions using the methods of Albee, Bosworth and Hibbs were performed on patients with spondylolisthesis at the Orthopaedic University Hospital Balgrist, Zurich. Long-term clinical results were rated as good in 80% of all patients operated on with the Albee method. The results after the Hibbs procedure on the other hand was good in only 65%. Progressive vertebral slipping after operation was seen in about 60% of all patients operated on by Albee's method, particularly in cases with severe spondylolisthesis. This slipping stops as soon as the intervertebral space had fused. Relief of the subjective symptoms also occured at this time. This phenomenon was only rarely seen after the Hibbs operation, in which the better postoperative stability leads to sclerosis of the discs indicating degenerative changes without a significant decrease in the disc height. The greater stability of the Hibb's fusion is more easily overstressed by body movements which can cause persistent symptoms and later lead to fatigue fractures.

Adult↗