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Biomedical subjects

Y Takenaka

Publications and source records attributed to Y Takenaka.

At least 19 recordsLinked to original sources
PubMed1992

[Arthritis and polyenthesitis after viral pleuro-pneumopathy due to Coxsackie virus].

A sixty-one year-old male developed subacute polyenthesitis one month after the onset on pleuropulmonary disease. This last manifestation resolved completely six months later, whereas the enthesopathy ran a subacute course, improving over time. Three years after onset, the patient had monoarthritis of the left elbow and tendinitis of both Achilles tendons. During the course of the disease, neutralizing antibodies against Coxsackie virus A9 rose significantly then returned to normal when clinical manifestations improved. This finding suggests that viral infections may cause enthesopathy.

Arthritis↗
PubMed1992

Polyenthesitis.

We described the clinical symptoms and signs of 11 cases of polyenthesitis, confirmed by the presence of inflammation in biopsies and increased activity in scintigraphy. All cases are negative for HLA-B27, and there is no presence of systemic inflammatory reaction, radiographic sacroiliitis, or chronic arthritis. The enthesitis is not ossifying and follows a rather benign clinical course. In one case, herpes virus-like particles were detected in the fibroblast debris of the tissue removed from Achilles tendon insertion. This fact suggests that polyenthesitis may be a clinical manifestation due to a reaction to an infectious agent.

Adolescent↗
PubMed1992

Diagnostic significance of urinary sialic acid in diabetic nephropathy.

The diagnostic significance of urinary sialic acid (SA) determinations was evaluated in relation to the histological findings of renal biopsy specimens. The subjects enrolled in this study comprised 82 diabetics. They were divided into 4 groups according to Gellman's criteria, namely D0, DI, DII and DIII approximately IV. Thirty non-diabetic healthy volunteers were used as controls. The urinary SA was measured by high performance liquid chromatography, and the urinary albumin excretion was estimated by solid phase radioimmunoassay. In addition, urine samples were assayed for N-acetyl-beta-D-glucosaminidase (NAG) and beta 2-microglobulin (beta 2MG). The urinary level of total SA (under conditions of hydrolysis) was significantly increased in the DII and DIII approximately IV groups as compared to the controls; however, a similar value was observed in the D0, DI and control groups. The urinary level of glycoprotein-bound SA was significantly increased in all diabetics as compared to the control group, and was significantly higher in the DII and DIII approximately IV groups than in the D0 and DI groups. The bound-SA/total-SA ratio (B/T ratio) showed a significant increase with respect to the progress of diffuse lesions. A weak correlation was noted between the B/T ratio and urinary protein excretion. However, there was no correlation between the B/T ratio and other indices. The urinary SA is considered to represent a useful indicator for estimating diabetic nephropathy.

Adult↗
PubMed1991

The effect of alpha-tocopherol as an antioxidant on the oxidation of membrane protein thiols induced by free radicals generated in different sites.

Azo compounds enable us to generate peroxyl radicals by thermal decomposition at a constant rate and at a desired site, that is, water-soluble compounds produce initiating radicals in an aqueous phase and lipid-soluble compounds initiate the oxidation within the membrane-lipid layer. Using these radicals generated in different sites, we oxidized red blood cell ghost membranes to study the relationships between alpha-tocopherol depletion, initiation of lipid peroxidation, and protein damage. When radicals were generated in the aqueous phase, the loss of membrane protein thiols was observed concurrently with the consumption of membrane tocopherol and after tocopherol was exhausted the peroxidation of membrane lipids occurred. On the other hand, when radicals were initiated within the lipid region, the oxidation of thiols and the formation of thiobarbituric acid-reactive substances were suppressed to give an induction period until tocopherol fell below a critical level. Our results indicate that the surface thiols of extrinsic proteins may compete with alpha-tocopherol for trapping aqueous radicals and spare tocopherol to some extent, whereas the oxidation of intrinsic buried thiols may commence due to lipid-derived radicals produced after tocopherol was consumed. In conclusion, alpha-tocopherol in the membrane can break the free radical chain efficiently to inhibit the lipid peroxidation. However, the effect of tocopherol on the inhibition of membrane protein damage, exhibited by the loss of thiols and the formation of high-molecular-weight proteins, would be different depending on the site of initial radical generation.

Amidines↗
PubMed1990

A new type of blood component collector: plasma separation using gravity without any electrical devices.

A new type of blood component collector (BCC) was developed to divide 450 ml of whole blood into plasma and a red cell concentrate using gravity without electrical devices. This BCC system is composed of one whole blood collection bag, two product collection bags and a plasma separator, which consists of a bundle of hydrophilized polyethylene hollow fibers (0.2 micron pore size). Without rinsing the plasma separator, the whole blood (458.1 +/- 13.5 ml, n = 22) was run through the separator using gravity without a pump. An average of 175.9 ml of plasma was collected within 11 min without hemolysis. In this completely cell-free plasma, the recovery of total protein, albumin, globulin, IgG and IgA was nearly 100%. Prothrombin time and activated partial thromboplastin time were in a normal range and the activity of coagulation factors did not change after the separation. In the red cell concentrate, the recovery of red cells, white cells and platelets was 94.7, 98.4 and 82.7%, respectively. Osmotic fragility of red cells, platelet morphology and functions did not change. These observations suggest that this new type of BCC is useful as a simple, fast and safe component collector.

Blood Platelets↗
PubMed1989

Multimodal treatment of hepatocellular carcinoma.

Our multimodal treatment of hepatocellular carcinoma (HCC) has brought about a significant improvement of the survival rate. It consists of a combination of hepatectomy and transcatheter arterial embolization using lipiodol (L-TAE). In order to facilitate L-TAE, we have developed a special catheter with notches. A group of patients with HCC (124 cases), excluding cases with absolutely non-curative resections and operative deaths, were treated between December 1980 and November 1986. Each case was treated for more than 1 year after hepatectomy. The patients were divided into two groups: A, patients with a single tumor not larger than 5 cm, and B, cases with larger tumors or more than one lesion. Some patients in each group were treated with L-TAE after hepatectomy. In group A, there was no significant difference in survival between treated and non-treated cases. In group B, L-TAE gave a significantly better survival than no postoperative treatment.

Carcinoma, Hepatocellular↗
PubMed1989

Changes in membrane constituents and chemiluminescence in vitamin E-deficient red blood cells induced by the xanthine oxidase reaction.

The oxidation of vitamin E-deficient rat red blood cells (RBCs) induced by the hypoxanthine-xanthine oxidase (HX-XOD) system has been performed in an aqueous suspension. The generation of chemiluminescence and the accumulation of thiobarbituric acid-reactive substances (TBARS) were observed initially and were followed by hemolysis. Interestingly, the total counts of chemiluminescence were closely related to the amount of TBARS. The predominant change of membrane proteins induced by the reaction was the depletion of spectrin bands in gel electrophoresis. When RBC ghosts were oxidized with HX-XOD, the sulfhydryl (SH) groups of membrane proteins decreased at an early stage of the incubation, which was coincident with the above protein alteration. Membrane alpha-tocopherol suppressed not only the formation of TBARS but also chemiluminescence and hemolysis; nevertheless, it did not inhibit the protein damage and the loss of SH groups. Moreover, it was concluded that the chemiluminescence observed during the oxidation of RBC membranes was associated mainly with the peroxidation of lipids and only to a minor extent with the oxidation of proteins.

Animals↗
PubMed1989

[Development of the database on nonproprietary names of drugs].

This paper describes the outline of the database of nonproprietary names of drugs and the characteristics of its online search system. The database includes the records of officially authorized names by WHO, International Nonproprietary Names (INN), and those by Japanese Government, Japanese Accepted Names (JAN). The INN file is merged with the JAN file. The online retrieval system is designed to enable search for drugs by generic names adopted on an international level and a national level in both English and Japanese. It is operated with INQ (DBMS) in the NEC ACOS-6 computer. Data from INN are updated once a year, and those from JAN are added whenever the official announcement of newly approved drugs are published in Yakumu-Koho (official pharmaceutical gazette).

Database Management Systems↗
PubMed1989

[Arterial-portal shunting in hepatic cavernous hemangioma; a case report].

A 60-year-old woman had a small hepatic tumor in the right lobe detected by CT scan. Angiography showed a hypervascular lesion with shunting of dense contrast material into portal vein radicles. Resected specimen revealed a cavernous hemangioma. The angiographic differentiation between small hemangiomas and malignant hypervascular neoplasms of the liver can be difficult.

Arteriovenous Fistula↗
PubMed1988

Combined peripheral and central chemoembolization of liver tumors. Experience with lipiodol-doxorubicin and gelatin sponge (L-TAE).

Patients with primary and a few with secondary liver tumors were embolized through the hepatic artery. Lipiodol and doxorubicin occluded peripherally, which was immediately followed by central embolization with gelatin sponge cubes. Preoperative embolizations were made for diagnostic and possible surgical adjuvant purposes. Extensive postembolization necrosis was common in tumors less than 5 cm in diameter, and tumor markers usually decreased temporarily after treatment. There were moderate side effects of pain, fever and nausea, and an acceptable complication and mortality rate with no deaths after embolization alone. This warrants further research on the method, which also seemed to improve the detection rate for small hepatocellular carcinomas.

Carcinoma, Hepatocellular↗
PubMed1988

[Preoperative intra-arterial infusion chemotherapy in locally advanced primary breast cancer-tissue concentrations of 5-fluorouracil and adriamycin, and the histological evaluation].

The effect of preoperative intra-arterial infusion of mitomycin C, 5-fluorouracil (5-FU) and adriamycin (ADM) were studied in seven patients with locally advanced breast cancer, including five inflammatory carcinomas, and a patient with stromal sarcoma of the breast. Reducing rate of the primary tumor of more than 30% was observed in all cases, and remarkable degenerative changes of tumor cells were histologically noted in six out of eight surgical specimens. The tissue concentrations of 5-FU and ADM were also studied in five breast cancer patients. There was no correlation between the concentration of 5-FU or ADM and histological effect. In intra-arterial infusion, ADM seemed to have a high affinity to the regional lymphnode and breast tumor, compared to normal breast tissue and might also be applicable to the control of lymphnode metastasis. Three out of six cases which received radical mastectomy subsequently had recurrence except in the regional lymphnodes and the prognosis was unsatisfactory (5 year survival was 2/4). Other alternative or multi-disciplinary treatment seems to be necessary for improving the survival rate.

Adult↗
PubMed1987

Factors affecting success and IOP rise after argon laser trabeculoplasty.

One hundred and seventeen eyes of 98 patients with open-angle glaucoma where maximum tolerable medication failed to control the intraocular pressure (IOP) were treated by argon laser trabeculoplasty. We applied multiple logistic regression analysis to the clinical data of these eyes to determine the factors which are related to the success rate and the immediate postoperative elevation of the IOP. The treatment was regarded as a success when the IOP was maintained at or below 20 mmHg during the postoperative follow-up. The treatment was judged as a failure when the IOP at two consecutive visits of the patient exceeded 20 mmHg or other surgical intervention was contemplated because of uncontrolled IOP. According to the above criteria, the success rate was found to be related to the pretreatment base line IOP, the type of glaucoma, the sex, the age and the history of previous ocular surgery. The computed logistic function could classify correctly 80% of eyes that had successful IOP control and 65% that did not. The immediate postoperative elevation of IOP was found to be related to the base line IOP, the laser power, the age and the type of glaucoma. The computed logistic function could classify correctly 74% of eyes with positive IOP rise by more than 5 mmHg and 75% with negative IOP rise.

Adult↗
PubMed1987

One-quadrant argon laser trabeculoplasty and its indication.

Argon laser trabeculoplasty (ALT) with 25 burn spots over the inferotemporal quadrant of the angle circumference was carried out in 71 eyes of 55 patients with open-angle glaucoma where maximum tolerable medication failed to control the intraocular pressure (IOP). Eighteen eyes underwent a second treatment, over the inferonasal quadrant. The overall success rate of the postoperative IOP control below 20 mmHg with continued medication was analyzed by means of a life-table method. It was 68 +/- 8% after 15 months. One-quadrant ALT gave approximately the same IOP control rate with less complications when compared to the results of the standard 180-degree ALT.

Adolescent↗