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Biomedical subjects

Y Takiuchi

Publications and source records attributed to Y Takiuchi.

At least 19 recordsLinked to original sources
PubMed1984

Naturally occurring T lymphocytotoxic antibody in viral and related skin diseases.

The naturally occurring T lymphocytotoxic antibodies in patients with viral and related skin diseases were investigated and compared with those of systemic lupus erythematosus (SLE). The incidences of T lymphocytotoxic antibodies in exanthema suspected of viral infection, infectious mononucleosis, rubella and pityriasis rosea were 28%, 44%, 8% and 28% respectively. Sera from patients with herpes zoster and erythema infectiosum did not show positivity. Incidence in SLE sera as positive control was 82%. The T lymphocytotoxic antibodies detected in skin diseases were similar in nature to those of SLE patients, but were transient and lower in titer than those of SLE.

Antibodies, Viral↗
PubMed1982

Antibodies to adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: a nation-wide sero-epidemiologic study.

A nation-wide sero-epidemiologic survey of adult T-cell leukemia virus (ATLV), detected es anti-ATLA (ATLV-associated antigen), was made in Japan. Sera from adult donors in 15 different locations were screened for anti-ATLA. High incidences (6 to 37%) of antibody-positive donors were found in seven regions, one in northern Japan, and the others in southwestern regions. These areas are ATLV-endemic areas corresponding to ATL-endemic areas. Examination of sera from healthy donors aged 6 to 80 years in ATL-endemic areas showed an age-dependent increase of seropositive donors with a maximum of about 30% at 40 years of age. Anti-ATLA was found in all but two of 142 patients with ATL. Anti-ATLA-positive patients with ATL were mainly found in ATLV-endemic areas, and only a few in ATL-nonendemic areas. Six patients with cutaneous T-cell lymphoma in ATLV-nonendemic areas gave a negative reaction for anti-ATLA. The geometric mean titer of anti-ATLA of patients with ATL was higher than that of healthy donors.

Adult↗
PubMed1981

Several marker analyses of T-lymphoma cells in eight Japanese adults.

Lymphoma cells in eight adult Japanese patients with no evidence of overt leukemia throughout their clinical course were demonstrated to be of T-cell nature by combining studies of various immunologic cell surface markers and cytochemistry. The histologic diagnosis of these patients was diffuse histiocytic lymphoma in four patients, poorly differentiated lymphocytic lymphoma in two patients and mixed histiocytic and lymphocytic lymphoma in two patients, according to Rappaport's classification. In seven of the eight patients, the malignant appearance and the large number of E-rosetting cells readily led to the diagnosis of T-cell lymphoma. Human Ia-like antigens were unexpectedly detected on the malignant T cells in seven of the eight patients. TdT activity was elevated in two of the four patients tested. Acid phosphatase activity was always observed in the neoplastic T-cells, and this activity was tartrate resistant. Focal activity of acid alpha-naphthyl acetate esterase was detected in the malignant cells with somewhat mature appearances, but large immature cells had no or weak dispersed activity. Except for E-rosetting ability, malignant T-cells showed such variable properties that multiple marker analyses seem to be necessary in the diagnosis and the prediction of prognosis of these disorders. Frequent occurrence of T-cell malignancy in Japan was also discussed.

Adult↗
PubMed1980

T lymphocytes expressing human Ia-like antigens in infectious mononucleosis (IM).

In six patients with Epstein-Barr virus (EBV) induced infectious mononucleosis (IM) and in two patients with IM-like syndrome, peripheral blood lymphocytes in the acute and convalescent phase were tested for human la-like antigens as well as other cell surface markers. The major population of T lymphocytes in the acute phase showed la-like antigens, as detected by indirect immunofluorescence with heteroantisera, and the number of la-like antigen-positive T lymphocytes decreased with convalescence. The crossabsorption study indicated that the amount of la-like antigen on the surface of IM T cells was less than that of Raji cells.

Adult↗
PubMed1979

Lipopolysaccharide responsiveness of malignant lymphoid cells in a patient with hairy cell leukemia.

The malignant cells in a patient with hairy cell leukemia responded most evidently to lipopolysaccharide (LPS) in in vitro culture for 3 1/2 days when the conventional tritiated thymidine uptake method was used. Since the malignant cells from patients with several other forms of leukemia and the peripheral blood mononuclear cells from healthy individuals did not show a comparable degree of responsiveness to LPS, we could exclude the possibility that this response was due to effects on contaminating normal mononuclear cells or to the nonspecific conditioning effect through LPS-affected contaminating normal monocytes. Morphological changes were observed with photo- and electronmicroscopy. It is likely that the hairy cells from the patient did respond to LPS, and whether or not this phenomenon may be confined to this type of lymphoid leukemia is not being investigated.

Adolescent↗