Study of the interaction of soluble and particle-bound nicotinamide adenine dinucleotide pyrophosphorylase with cytoplasmic ribosomes.
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Adsorption↗
Biomedical subjects
Y Teitz
Publications and source records attributed to Y Teitz.
RNA dependent DNA polymerase in C type particles from normal rat thymus cultures.
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Animals↗
Release of C-type particles from normal rat thymus cultures and those infected with Moloney leukemia virus.
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Animals↗
Transformation and virus production in normal rat thymus cells and those infected with Moloney leukemia virus.
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Animals↗
Synthesis of nicontinamide-adenine dinucleotide by NAD pyrophosphorylase on a column of hydroxylapatite.
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Adenosine Triphosphate↗
T antigen from nuclear and cytoplasmic extracts from an adenovirus type 12 transformed cell line.
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Adenoviridae↗
A temporal and structural relationship between viral RNA polymerase and nicotinamide adenine dinucleotide pyrophosphorylase in the cytoplasm of Krebs-2 ascites cells infected with encephalomyocarditis virus.
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Animals↗
Isolation of different-sized nucleoli from normal and regenerating rat liver.
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Animals↗
Relationships between structure and antiretroviral activity of thiosemicarbazone derivatives.
In an attempt to develop anti-AIDS drugs, the compound isatin beta-thiosemicarbazone has been subjected to systematic structural modifications. The resulting synthesized thiosemicarbazone derivatives (TSCDs) were examined for their ability to act as antiretrovirus agents in a model system--2M3/M cell system--consisting of B lymphocytes transformed by the v-abl oncogene and chronically infected with a retrovirus, the Moloney leukemia virus (M-MuLV). The efficacy of the synthesized TSCDs against retroviruses was determined by assaying the therapeutic index (TI) values of the compounds. The results enabled the classification of TSCD groups based on the relationship between chemical structure and antiretroviral activity. The compound N-allylisatin-beta':4'-diallylthiosemicarbazone showed the highest TI value and efficiently suppressed the chronic infection of M-MuLV in continuous long-term treatment.
B-Lymphocytes↗