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Biomedical subjects

Y Thomassen

Publications and source records attributed to Y Thomassen.

At least 73 records · Page 4Linked to original sources
PubMed1986

Multielemental characterization of human lung tissues by ICP-AES.

Preliminary results on multielement analysis of human lung tissues with inductively coupled plasma atomic emission spectrometry (ICP-AES) are reported. Three different sample preparation procedures have been studied; dry ashing at 450 degrees C or low temperature ashing followed by pressure digestion with aqua regia and hydrofluoric acid or direct acid digestion with nitric-, sulfuric- and perchloric acid.

Elements↗
PubMed1986

Short-term effects of mating on the accessory sex glands of the male rat.

Mating in the rat was associated with a significant reduction in the tissue concentrations of the presumptive secretory products of the male accessory sex glands: prostatein and the amines, putrescine, spermidine and spermine (ventral prostate lobe), zinc (lateral prostate lobe) and fructose (coagulating gland). The amount of secretory product discharged and the time taken to restore precopulatory levels differed for the different lobes. Within 12-24 h of the mating period, the activity of ornithine decarboxylase and cytosolic oestrogen binding in the ventral prostate lobe underwent a transient increase which lasted 2-3 days. No change was observed in prolactin binding. Circulating testosterone concentrations were significantly elevated above control values 12 h after the start of mating but were significantly lower than control values at 24 h. A gradual recovery to concentrations in controls occurred over the next 2-3 days. None of these changes could be explained by alterations in gonadotrophin or prolactin release.

Androgen-Binding Protein↗
PubMed1986

Selenium, alcohol and liver diseases.

A possible pathogenetic role of selenium deficiency in alcoholic cirrhosis of the liver has previously been discussed. In the present study, serum concentrations of selenium, copper and zinc were analyzed in alcoholic cirrhosis as well as in chronic active hepatitis and primary biliary cirrhosis. The serum concentrations of selenium were consistently decreased in patients suffering from alcoholic cirrhosis. Zinc values were also low in these patients. Studies of a possible therapeutic effect of zinc and selenium supplementation are of interest. Other authors have reported increased hepatic lipoperoxidation and decreased hepatocellular glutathione levels in animals consuming ethanol. It is hypothesized that the low levels of Se and Zn, in combination with the reported glutathione depletion, makes the hepatocytes more vulnerable toward the toxicity of ethanol.

Animals↗
PubMed1985

Short-term effects of prolactin on prostatic function in rats with lisuride-induced hypoprolactinaemia.

The effects of a single injection of ovine prolactin on prostatic function were monitored in intact, intact androgenized and castrated-androgenized rats rendered hypoprolactinaemic after 7 days of treatment with a potent dopamine agonist, lisuride. Hypoprolactinaemia was associated with reductions in ventral prostate weight, polyamine levels, lateral lobe zinc and the concentration of the ventral prostate protein prostatein, but an elevation in the level of cytosolic oestradiol binding. Whether these differences attained statistical significance depended on whether the animals were intact, intact-androgenized or castrated-androgenized. With the exception of ventral prostate weight and lateral lobe zinc concentrations, a single injection of prolactin restored or reversed these changes towards control levels within 12 h, which could not be explained by an indirect effect of the hormone on adrenal or testicular function. No effects of lisuride or prolactin were observed with regard to the content of fructose in the coagulating gland or in the degree of prolactin binding to prostatic membranes.

Androgen-Binding Protein↗
PubMed1984

Seminal plasma characteristics during frequent ejaculation.

Seven young men provided a semen sample every 8 h for 2 days. Citric acid, zinc, acid phosphatase , spermine, fructose and protein were measured in the samples. Despite a dramatic reduction in semen volume, the concentration of the majority of the parameters remained constant during the period of study. The protein profile of the ejaculates, as assessed by 2-dimensional electrophoresis, also did not change. Levels of citric acid, zinc and acid phosphatase were closely correlated, while spermine, which is also believed to be of prostatic origin, showed no correlation with these other parameters. The spermine concentration of the ejaculates increased significantly during the period of high ejaculation frequency and returned to normal levels after a 3 day abstinence period. In view of the fact that spermine accumulation in tissues appears to be associated with growth and protein synthesis this increase in seminal spermine may reflect a stimulation of prostatic cell activity.

Acid Phosphatase↗
PubMed1982

Serum selenium levels in liver diseases.

A possible pathogenetic role of selenium deficiency in alcoholic cirrhosis of the liver has previously been discussed. In the present study serum selenium was analyzed in 5 groups of liver diseases. The method used for selenium determination was electrothermal atomic absorption, after thermal stabilization of selenium compounds by addition of nickel nitrate. The selenium level of a reference group of healthy Norwegian adults (n = 40) was 1.53 +/- 0.25 mumol/l. The serum concentrations of selenium in patients suffering from alcoholic cirrhosis, chronic active hepatitis and chronic persistent hepatitis were lowered to 40-80 per cent of those of the reference group. In alcoholic cirrhosis and chronic active hepatitis the decreased serum selenium concentrations were significantly correlated to decreased levels of albumin and prealbumin.

Hepatitis, Chronic↗
PubMedDate not supplied

Cadmium and selenium in blood and urine related to smoking habits and previous exposure to mercury vapour.

The object of this work was to investigate possible interactions of mercury, cadmium and selenium in humans. Selenium and cadmium in blood and urine were determined in this cross-sectional study of 130 males, of whom 77 had been previously exposed to mercury vapour at a chloralkali plant. Of the participants, 61.5% were smokers and 16.2% were never-smokers. The concentration of selenium in blood (B-Se) was significantly lower in subjects currently smoking more than 50 g of tobacco per week compared to never-smokers, whereas the concentration of cadmium in blood (B-Cd) was significantly higher in all categories of current smokers. In the multiple linear regression analysis, B-Se as a dependent variable was negatively associated with B-Cd, whereas current smoking habits were not included in the model as a predictor variable. In contrast, B-Cd as a dependent variable was positively associated with current as well as previous smoking habits, and negatively with both B-Se and the 'cumulative dose' of previous mercury vapour exposure. The concentration of selenium in blood was also negatively associated with B-Cd in the group of never-smokers (Spearman's r = -0.80; P < 0.001). In conclusion, these results suggest a depressive effect of cadmium on the concentration of selenium in blood, while smoking alone did not operate as a true predictor for this effect. Furthermore, previous exposure to mercury apparently modifies the concentration of cadmium in blood.

Adult↗