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Biomedical subjects

Y Thoua

Publications and source records attributed to Y Thoua.

At least 19 recordsLinked to original sources

[Recurrence of Wegener's granulomatosis in a cadaver kidney graft].

Early recurrence of Wegener's granulomatosis on a kidney graft is described in a 35-year-old patient. The differential diagnosis of renal microvasculitides is discussed as well as the problem related to characterization and specificity of antineutrophil cytoplasmic antibodies. Possible factors influencing the risk of recurrence of Wegener's granulomatosis on the graft are detailed after reviewing five cases from the literature.

Adult↗

US demonstration of pyelitis and ureteritis in children.

The authors report a new ultrasonic sign of urinary tract infection in children: thickening of the renal pelvis and/or ureteral wall. This thickening as encountered in 10 children, (10 months to 12 years) all with urinary tract infection, appears to result from inflammatory changes and to correspond to a sonographic sign of pyelitis and ureteritis. These alterations of the walls are similar to striations and folds described in this pathology on intravenous pyelograms. The thickening was the only sign of abnormality of the urinary tract in two cases; it was observed without reflux in four cases. The demonstration of this pattern should lead to further uroradiological investigations and to appropriate treatment.

Child↗

Long-term follow-up of separate glomerular filtration rate in partially obstructed kidneys. Experimental study.

An often encountered assumption is that non-relieved renal obstruction will lead soon or late to progressive deterioration of the renal function. The effect of non-relieved partial ureteral obstruction on the separate glomerular filtration rate (SGFR) was studied throughout the whole life of a series of rats, who were submitted at the age of 3 months to partial obstruction of the left ureter. An initial and variable postoperative SGFR decrease was gradually observed, but after this period, SGFR remained stable until the natural death of the animal.

Animals↗

[A rare recurrent sinus tumor].

The schneiderian papilloma, rare tumor of the nose and paranasal sinuses, have a marked predominance of men in the fourth or fifth decade of life. The most common symptom is an unilateral progressive nasal obstruction. Abnormal tissue in the nasal fossa is found in all cases. A capacity to destroy, a tendency to recur and an association with malignancy characterise this tumor with an obscure aetiology. Radical surgery is advocated as a treatment of choice, an adequate method is the lateral rhinotomy.

Aged↗

Multicystic dysplastic kidney: natural history from in utero diagnosis and postnatal followup.

Based on our experience with 13 in utero diagnoses we report the changes that may occur in the ultrasonic appearance of a multicystic dysplastic kidney. Macrocysts appear obvious only in the early third trimester of pregnancy. After reaching a maximum size the cysts start to involute either in utero or after birth, which may lead to a small noncystic mass, the so-called aplastic kidney, or even to complete disappearance of the entire dysplastic kidney. The dysplastic kidney seems vulnerable to anoxia or infection, and necrosis may supervene. The multicystic dysplastic kidney is a progressive and changing disorder. If its radiological appearance is typical management may be conservative with ultrasonic monitoring. Nephrectomy should be done if there is any abnormal clinical or ultrasonic change.

Female↗

Development of the hypodysplastic kidney: contribution of antenatal US diagnosis.

Two cases of fetal perirenal uriniferous pseudocyst were diagnosed in utero with ultrasound studies. The perirenal collections resolved spontaneously in utero. Follow-up examination showed growth impairment of the affected kidney. At birth, no renal function was demonstrated in one case and only slight function in the other case. Pathologic examination showed a highly dysplastic kidney with extravasated urine in the case in which surgery was performed. Some hypodysplastic kidneys apparently result from acute in utero obstruction with secondary pyelocalyceal rupture. Renal dysplasia could render the kidney more vulnerable to such phenomena.

Adult↗

Autoimmune disease after neonatal injection of semi-allogeneic spleen cells in mice: involvement of donor B and T cells and characterization of glomerular deposits.

Balb/c neonates injected with semi-allogeneic (A/J x Balb/c) F1 hybrid spleen cells develop an autoimmune disease associated with an immune-complex glomerulonephritis. The successful induction and maintenance of B cell chimerism is required for the occurrence of autoimmunity. The percentage of chimeric mice displaying autoimmune features increases in parallel with the number of cells injected at birth. T cell depleted inocula although readily inducing B cell chimerism were found unable to induce hypergammaglobulinaemia, circulating immune complexes and glomerulonephritis. IgG1 is the most and IgG3 the least represented IgG isotype among the immunoglobulins deposited in the glomeruli. Immunoglobulins bearing donor (A/J) allotype are detected in the glomeruli of six out of 11 chimeric mice. Rheumatoid factor activity is significantly concentrated within the immunoglobulins eluted from the kidneys, whereas anti-DNA activity is not.

Animals↗

Cyclosporine nephropathy after heart and heart-lung transplantation.

Cyclosporine nephrotoxicity after heart transplantation can lead to acute renal failure requiring haemodialysis. In four long-term heart-transplant survivors, cyclosporine nephropathy was characterised by extensive fibrosis, with uraemia, hypertension and/or anaemia. In contrast, the long-term survivor of heart-lung transplantation who had received her graft for accelerated respiratory failure, did not develop chronic renal disease. Thus, chronically reduced renal perfusion before heart transplantation may play a critical role in the development of chronic cyclosporine nephropathy.

Adult↗

[Synoviosarcoma: presentation of a case and review of the literature].

Synovial sarcoma is a rare tumour. The diagnosis is difficult because of the lack of typical clinical symptoms and microscopy can be controversial. The prognosis is bad. A case is described in a woman aged 63 who presented previously with osteopoikilosis without clinical signs. The sarcoma was situated at the knee and was at first confused with a degenerative arthritis. The patient died despite secondary amputation. After study of the literature the authors conclude that the prognosis may be improved by early diagnosis.

Adolescent↗