Biomedical subjects

Y W Linde

Publications and source records attributed to Y W Linde.

5 recordsLinked to original sources

PubMed1998

[Despite better knowledge of pathogenesis and treatment: atopic eczema--a disease with increasing incidence in Sweden].

The past twenty years have witnessed an increasing incidence of atopic dermatitis in Western Europe. The article consists in a discussion of the pathogenesis, clinical signs and treatment of this common skin disease. Both an IgE-mediated reaction on epidermal Langerhans cells, and a physiological/biochemical defect of the skin barrier structure may be crucial factors of the multifactorial pathogenesis. Local treatment with corticosteroids and moisturisers remains the basic approach, though the development of new more specific treatments is under way. Although much remains to be learned about atopic dermatitis, today all patients can be offered effective treatment resulting in improved quality of life.

Adult↗

PubMed1992

Friction, capacitance and transepidermal water loss (TEWL) in dry atopic and normal skin.

The biophysical properties of non-eczematous skin at three locations in atopics and non-atopics were characterized using non-invasive physical methods. Skin friction was measured with a newly developed sliding friction instrument, the degree of hydration with a capacitance meter (Corneometer CM 820), and the transepidermal water loss (TEWL) was determined using an Evaporimeter EP1. The areas examined (dorsum of the hand, volar forearm and lower back) showed lower values of friction and capacitance in the atopic patients than did corresponding sites in the normal controls. In most areas a significant correlation between friction and capacitance was found. The TEWL was increased in atopic skin, but TEWL seems to correlate neither to friction nor to capacitance.

Adult↗

PubMed1992

Dry skin in atopic dermatitis.

Atopic dermatitis (AD) is a common, chronically recurring skin disorder. Dry skin is a common finding in patients with AD, apart from the dermatitis. Although there are obvious clinical signs of an impaired barrier function of the skin, few investigators have studied this aspect of AD. The stratum corneum, where the barrier is located, has been studied with different techniques in patients with AD, and the results are now presented. The water-binding capacity of dry atopic skin was found to be reduced when measured with an in vitro microbalance technique. TEWL (transepidermal water loss) measured with and Evaporimeter Ep1, was increased in dry skin and in clinically normal skin of atopics on predilection areas. Water content was decreased in dry atopic skin, when measured with the Corneometer CM 420. In a quantitative electron microscopic study, the lamellar bodies were found to have an increased relative volume in dry atopic skin. When using chromatographic analysis, preliminary data suggested reduced amounts of extractable stratum corneum lipids in patients with AD. In a clinical study, 80% of the patients with AD regarded their skin as being dry. Fifty percent were found to have areas of dry skin, on clinical examination. By scanning electron microscopy (SEM), the surface pattern of dry atopic skin was found to be coarse and irregular. When using profilometry, quantitative differences in roughness parameters were found in dry atopic vis-à-vis to normal skin.(ABSTRACT TRUNCATED AT 250 WORDS)

Body Water↗

PubMed1989

'Dry' skin in atopic dermatitis. I. A clinical study.

A common finding in patients with atopic dermatitis is the occurrence of 'dry' skin on non-eczematous regions. 'Dry' skin is here defined as a clinical condition meaning a rough, finely scaling non-inflamed skin surface. The frequency and extension of 'dry' skin were examined in 50 patients with atopic dermatitis and were compared with those in 50 non-atopics. A discrepancy was found in both groups between the subjective opinion of the presence of 'dry' skin and the objectively noted 'dry' skin. Among the atopics, 48% were found to have 'dry' skin compared with 14% among the controls (p less than 0.01). The most frequent location of 'dry' skin in both groups was the back. Intolerance to wool was found to be significantly high (p less than 0.01) in the atopic group, although it was also quite common in non-atopics. In order to correlate the clinical observation to skin morphology, a replica-technique was used to visualize the surface of 'dry' skin in the scanning electron microscope.

Adolescent↗

PubMed1989

'Dry' skin in atopic dermatitis. II. A surface profilometry study.

In patients with atopic dermatitis, the skin is often 'dry' on non-eczematous areas, and feels rough to the touch. In the scanning electron microscope (SEM) this roughness corresponds to a change in the skin surface, from regular major and minor furrows into a coarse and irregular pattern. In the present study the topography of normal skin and 'dry' atopic skin was quantitatively recorded using a profilometry method. A computer-based three-dimensional reconstruction of the skin surface was made from replicas, and common roughness parameters were calculated. It was found that in the 'dry' atopic skin roughness parameters Ra, Rq, and Rmax, were significantly increased, whereas the number of peaks, Rn, was decreased. Parameters describing the shape (skewness, kurtosis, and delta a) of the profile were not significantly different. These topographical data clearly support the visual impression of the surface pattern of 'dry' atopic skin found in SEM.

Adolescent↗