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Y Y Yi

Publications and source records attributed to Y Y Yi.

4 recordsLinked to original sources
PubMed1990

[Hydrophobic modification of water soluble drug and its reconstitutable liposomes].

Water soluble drugs carried in liposomes have rather low encapsulation percentage (EP%) and poor stability. In this paper metronidazole (I) was chosen as a model of water soluble drugs which was modified by means of esterification. Its myristic ester (II) was synthesized. On studying the liposomes of I and II, the results have shown that EP% and stability of II were more than ten times as high as that of I. Furthermore, the reconstitutable liposomes of II were prepared successfully. The amoebacide activity of II liposomes was increased also. Therefore, the hydrophobic modification of water soluble drugs is a good way to improve the drug entrapped in liposomes.

Antiprotozoal Agents↗
PubMed1989

[Surface charged liposomes as drug carriers and in vivo tests of mice infected with toxoplasma].

The surface charge is one of the most important properties of liposomes. In this paper surface potential of liposomes was measured by fluorimetry using 1.8-ANS as a probe and by microelectrophoresis. The encapsulation efficiency and leakage rate of ionic drugs were influenced by the surface charge of liposomes. Higher encapsulation efficiency and lower leakage rate were resulted if the surface charge of liposomes was opposite to the ionic charge of encapsulated drug. Mice infected with toxoplasma were used as a model. In in vivo test, liposome-drug was compared with the free drug. The average survival days of groups of liposome-drugs were much longer than that of the group of free drugs. Mouse infected with toxoplasma is a simple, convenient and accurate model for measuring the biological activation of liposome-drugs.

Animals↗