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Biomedical subjects

Y YAGI

Publications and source records attributed to Y YAGI.

At least 19 recordsLinked to original sources
PubMed1965

ANTIBODIES AGAINST THE COMPONENT POLYPEPTIDE CHAINS OF BOVINE INSULIN.

Antibodies were produced in guinea pigs against A and B chains of bovine insulin; the chains were prepared by cleavage of all the disulfide bonds with sulfite. Antibodies against A chain reacted with A chain, but not with B chain or native insulin. Antibodies against B chain reacted strongly with both B chain and insulin, but not with A chain. Antibodies against insulin reacted strongly with insulin, weakly with B chain, and not at all with A chain. The results indicate that the insulin-reactive antibodies in antiserums to B chain and to insulin differ and are directed to differing individual antigenic regions of the insulin molecule.

Animals↗
PubMed1964

ANTIGEN-BINDING ACTIVITY OF 6S SUBUNITS OF BETA-2-MACROGLOBULIN ANTIBODY.

Direct evidence is provided for the antigen binding activity of the 6S subunits formed by reduction and alkylation of rabbit beta2-macroglobulin antibody. Binding activity of the subunits was clearly demonstrated by radioimmunoelectrophoresis with a preparation of purified rabbit antibody against the p-azobenzenearsonate group, which contained 40 percent of beta2M-antibody. The precipitate arc formed between the subunits and sheep antiserum against rabbit macroglobulin was shown to bind radioactive antigen specifically.

Animals↗