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Biomedical subjects

Y Yagil

Publications and source records attributed to Y Yagil.

65 records · Page 4Linked to original sources
PubMed1983

The combination of propranolol and nifedipine in the treatment of hypertension: acute and long term effects.

The long term efficacy and tolerability of nifedipine combined with propranolol was assessed in a group of hypertensive patients inadequately controlled on propranolol alone. Twenty-six subjects were initially treated with propranolol in a constant daily dose of 160-240 mg, for up to 4 weeks. Nifedipine, 30 mg/day, was added and the dose was titrated upwards to 90 mg/day to achieve normal blood pressure. In 22 patients receiving the combined therapy for 14-30 weeks, mean arterial pressure dropped from 138 +/- 3 mmHg to 102 +/- 2 mmHg. Thirteen patients experienced untoward effects, and 4 discontinued the study. In the remaining 9, side effects were mild and well tolerated. Seventeen patients were subsequently treated sequentially with propranolol alone, combined therapy and nifedipine alone, to assess the efficacy of each regimen and the additive effect of each drug. The combined regimen was found to be more effective than either drug alone. A subgroup continued either combined therapy (14) or nifedipine monotherapy (3) and was followed for up to 9 months. Blood pressure control was maintained in the majority, but 4 more patients dropped out because of side effects. We conclude that the long term use of nifedipine combined with propranolol is effective and relatively well tolerated, and may offer an alternative approach to the treatment of moderately severe hypertension.

Adult↗
PubMedDate not supplied

Building on the past--challenging the future: will genomics provide the solution to hypertension?

Hypertension is one of the major common polygenic and multifactorial diseases, and continues to constitute a major cause of morbidity and mortality worldwide. The pathophysiological mechanisms underlying hypertension have not been elucidated, which significantly limits our ability to treat and prevent hypertension. A frequently asked question is whether genomics will provide the solution to the many remaining unanswered questions as to the causes of hypertension. Genomics, an art by its own virtue, holds its promises, yet the questions we are asking of genomics must be well defined for genomics to meet at least some of our expectations. The hopes and promises of genomics are high and one of the major hopes is that genomics will improve our understanding of the pathophysiology of hypertension and enable us to classify hypertensive syndromes more succinctly and enhance our ability to provide patients with specific anti-hypertensive therapy as well as predict outcome. There is still much to be done but perseverance in the task and a firm belief in genomics and in the immense potential of the human genome is essential.

Genetic Predisposition to Disease↗
PubMedDate not supplied

Effectiveness of combined nifedipine and propranolol treatment in hypertension.

The long-term antihypertensive effect of combined nifedipine and propranolol therapy was assessed in an open trial in 26 hypertensive patients (19 men, seven women, mean age 53 years). On propranolol alone (160 to 240 mg/day), the patients' average sitting blood pressure was 192 +/- 5/114 +/- 2 mm Hg. Propranolol was continued in a fixed dose and nifedipine was added in a dose that was gradually increased from 30 to 90 mg/day to achieve blood pressure (BP) values below 160/95 mm Hg. Twenty-two patients remained on the combined regimen for 14 to 30 weeks. Their BP decreased to 136 +/- 3/84 +/- 2 mm Hg on an average daily dose of 59.5 mg nifedipine. Seventeen of the 22 subjects were subsequently treated sequentially with propranolol alone, combined therapy, and nifedipine alone, to assess the relative efficacy of each mode of therapy. The combined regimen was found to be more effective than either drug alone. Side effects occurred in 13 of 26 patients. Four dropped out 4 to 11 weeks after starting nifedipine because of either intolerable flushing (2), allergic rash (1), or headache (1). Nine subjects experienced mild reactions that were well tolerated. It is concluded that the combined use of propranolol and nifedipine is effective in the long-term treatment of moderately severe hypertension and offers an alternative therapeutic approach that deserves further evaluation.

Adult↗