PubMed Health⌕ Search

Biomedical subjects

Y el-Sayed

Publications and source records attributed to Y el-Sayed.

12 recordsLinked to original sources
PubMed1998

Acquired medial canal fibrosis.

Acquired medial canal fibrosis is a discrete clinicopathological entity characterized by formation of fibrous tissue in the bony external auditory meatus. Over a seven-year period, a total of 14 operative procedures were performed on 12 ears involving 10 patients. Four cases had followed otitis externa, two were complications of suppurative otitis media, and three cases were iatrogenic. The cause could not be identified in three ears involving two patients. Treatment entails excision of all the fibrous tissue and involved skin, a wide canaloplasty, a meatoplasty, and then reconstruction by split skin graft. Two cases of canal cholesteatoma were encountered. Average follow-up of two years showed hearing improvement in all patients. The only complication was a recurrence of the stenosis in two ears. The paper discusses terminology, aetiology, pathophysiology, diagnosis, and principles of treatment of this condition.

Adult↗
PubMed1997

Lobular capillary haemangioma (pyogenic granuloma) of the nose.

OBJECTIVE: To present a number of cases with lobular capillary haemangioma (pyogenic granuloma) of the nose; and to discuss the clinical and histopathological diagnosis of this disorder. METHODS: A clinicopathological study of patients diagnosed with nasal lobular capillary haemangioma who were treated at King Abdel Aziz University Hospital, Riyadh from 1986 to 1995. RESULTS: The study group consisted of 12 patients (four males and eight females ranging in age from 17 to 65 years; mean 30.1 years). Clinically, most patients presented with epistaxis and a rapidly growing unilateral haemorrhagic mass. Most lesions were located on the septal mucosa. The clinical impression was misleading in some cases. The histological diagnosis was based on the lobular arrangement of capillaries. One case was initially misdiagnosed as angiofibroma. Excisional biopsy was the mainstay of treatment. One instance of recurrence was recorded. CONCLUSION: This uncommon lesion should be considered in the differential diagnosis of a rapidly growing haemorrhagic lesion within the nasal fossa. Clinical and histological diagnostic pitfalls occur frequently.

Adolescent↗
PubMed1997

Otological manifestations of primary ciliary dyskinesia.

Primary ciliary dyskinesia is a hereditary defect in the ultrastructure of cilia, leading to poor ciliary motility. The sinonasal and the bronchial manifestations of the disease are well documented; whereas its otological aspects have received less attention. In this report, we describe the clinical profile of 16 patients with primary ciliary dyskinesia laying particular emphasis on the otological manifestations. All children (11 patients) had bilateral otitis media with effusion. Of the five adults, three had tympanosclerosis; one had bilateral cholesteatoma; and one patient had bilateral keratosis obturans in combination with tympanosclerosis. Hearing improvement and a dry ear was achieved in all the children treated by tympanostomy tube insertion. The study suggests that otitis media is a prominent feature of this disorder. Most subjects suffer from protracted bilateral otitis media with effusion throughout childhood.

Adolescent↗
PubMed1996

Deep-neck space abscesses.

OBJECTIVE: Despite a reduction in the incidence, deep-neck space infections are still seen today with definite potential for significant morbidity and even mortality. DESIGN: The authors present their experience in the management of 16 patients with 19 deep-neck space abscesses. The distribution of the abscesses were: 5 Ludwig's angina, 4 parapharyngeal abscesses, 3 retropharyngeal abscesses, 3 in the sub-mandibular triangle, 3 in the deep anterior triangle, and 1 in the deep posterior triangle. RESULTS: The source of infection was odontogenic in six patients, pharyngeal in three, otogenic in one, and could not be identified in the other six patients. Most cases presented with pain and neck swelling. Plain x-ray films, computed tomography, ultrasonography, and magnetic resonance imaging were the main diagnostic procedures. Positive culture was obtained in only nine cases (56.2%). No predominant single organism was identified. Antimicrobial therapy and surgical drainage were the mainstay of treatment. Two cases were complicated by internal jugular-vein thrombophlebitis. All the patients survived without major residual sequelae. CONCLUSIONS: The etiology, presentation, and management of deep-neck space infections are briefly reviewed.

Abscess↗
PubMed1996

Cicatricial pemphigoid of the larynx: a case report of surgical treatment.

Although laryngeal stenosis caused by cicatricial pemphigoid (CP) is a well documented entity, reports about its surgical treatment are scant. This may be due to the reluctance of the surgeons to excise the scarring, knowing the recurrent nature of the disease. In this paper we report a case of severe laryngeal stenosis caused by CP which necessitated a tracheostomy. When the disease had stabilized, laryngeal airway was restored following open surgical excision and stenting. The historic, clinical, histologic, immunopathologic and therapeutic features of CP are presented with special reference to the laryngeal lesions.

Female↗
PubMed1995

Point prevalence of type B tympanogram in Riyadh.

Secretory otitis media (SOM) is primarily a disease of children which can have deleterious effect on their medical, social, educational and psychological welfare. It is well known that SOM is a common disease, but exact figures about its prevalence and incidence are scarce and fragmentary. In this community study, we determined the point prevalence of type B tympanogram as an indication to the prevalence of SOM. The study population consisted of a random sample of 4214 children aged 1-8 years. The point prevalence rates of unilateral and bilateral type B tympanogram among the children were 5.7% and 8.1%, respectively. The point prevalence rate per ears (a total of 8428) was 10.9%. The prevalence was found to be related to the age, the season and to the occurrance of the ear and upper respiratory tract infections. No correlation was found in relation to sex, allergy or the socio-economic condition. The findings are discussed in the light of studies conducted elsewhere.

Acoustic Impedance Tests↗
PubMed1995

Sinonasal teeth.

Ectopic eruption of the teeth in the sinonasal tract and the migration of a displaced dental fragment from the maxillary sinus to the nose are two rare phenomena. This paper reports three cases: an asymptomatic ectopic tooth within the nasal septum, an ectopic maxillary sinus tooth causing repeated attacks of sinusitis, and a dental root that reached the nose through the maxillary antrum associated with Aspergillus sinusitis. The etiology, diagnosis, complications, and treatment of simonasal teeth are discussed.

Adult↗
PubMed1993

Acute visual loss in association with sinusitis.

Acute visual loss may occur in association with sinusitis either as a complication of orbital cellulitis or, less frequently, as a part of the orbital apex syndrome. We describe two cases of temporary monocular visual loss caused by sinusitis. In one case the visual loss was due to orbital cellulitis; while in the other patient it was due to incompletely developed orbital apex syndrome. This later mode of presentation is called 'partial orbital apex syndrome' by some authors and 'posterior orbital cellulitis' by others. The relationship between sinusitis and blindness is discussed.

Acute Disease↗
PubMed1992

Fibromatosis of the head and neck.

The purpose of this paper is to focus attention on this rare disorder. Two cases are reported: one involving the neck and the other the nose and paranasal sinuses. The treatment of choice is wide surgical excision wherever possible.

Ethmoid Sinus↗
PubMed1989

A study on the relative bioavailability of a sustained-release formulation of diclofenac sodium.

The bioavailability of an in vitro sustained-release formulation of diclofenac sodium was compared with a conventional product in six healthy male volunteers. The administration of a single dose (100 mg) of either formulation in a crossover design revealed significant differences in the extent of absorption as assessed by AUC. The relative bioavailability of the sustained-release formulation was found to be 53% compared with the conventional product. The Cmax for the sustained release formulation (0.54 +/- 0.29 micrograms ml-1) was significantly much lower than the corresponding value for the conventional formulation (4.12 +/- 0.91). However, the tmax for the sustained release formulation (3.6 +/- 2.1 h) was not significantly different from the corresponding value for the conventional formulation (2.5 +/- 0.4 h). Although the sustained release formulation showed serum concentration-time profiles characteristic of sustained products in vivo, it failed to attain therapeutic drug levels. The in vivo results were found inconsistent with the in vitro availability of the drug.

Adult↗
PubMed1988

Comparative bioavailability and in vitro characterization of two brands of diclofenac sodium enteric-coated tablets.

A bioavailability study and an in vitro characterization were conducted on two brands of diclofenac sodium enteric-coated tablets marketed in Jordan. The two brands were found similar in weight variation and content uniformity and both met the BP requirements of disintegration for enteric-coated tablets. The in vitro dissolution, according to the USP XXI method, revealed that brand B had significantly faster dissolution (99% of the drug dissolved in 1 h). The bioavailability was carried out on eight healthy male volunteers who received a single dose (2 x 50 mg) of each product in a crossover design. Blood samples were obtained over a 10 h interval and drug serum concentrations were determined using a sensitive HPLC assay. The two brands did not significantly differ with respect to peak serum concentration (4.4 and 4.5 micrograms.ml-1 for A and B, respectively) or to the lag time between dosing and the appearance of the drug in serum (1.06 and 0.88 h for A and B, respectively). Further, the two brands were not found significantly different with respect to the extent of absorption as indicated by the area under serum concentration-time curve (6.31 and 5.91 micrograms.h.ml-1 for A and B, respectively). Brand B, however, exhibited a significantly earlier time to attain peak serum concentration (1.2 h) compared to brand A (2.4 h). The difference in the tmax values is consistent with the in vitro dissolution pattern for the two brands.

Adult↗