Biomedical subjects

Yael Villa

Publications and source records attributed to Yael Villa.

11 recordsLinked to original sources

PubMed2007

Risk-taking behaviors among Israeli adolescents exposed to recurrent terrorism: provoking danger under continuous threat?

OBJECTIVE: This study aimed to assess 1) the relationship between risk-taking behaviors and exposure to terrorism, 2) the relationship between posttraumatic symptoms and risk-taking behaviors, and 3) gender differences in the type and frequency of risk-taking behaviors and their differential associations with posttraumatic symptoms. METHOD: The participants were 409 Israeli adolescents 15 to 18 years of age. Exposure to terrorism was assessed with a questionnaire developed specifically for the Israeli security situation. Posttraumatic symptoms were measured with the University of California at Los Angeles Reaction Index. Functional impairment was measured with the Diagnostic Interview Schedule for Children. Risk-taking behavior-and the adolescents' perceptions of such behavior-was assessed with a self-report questionnaire. RESULTS: Israeli adolescents exposed to continuous threats of terrorist attacks reported high levels of risk-taking behaviors. The severity of risk-taking was associated with greater terrorism exposure. Adolescents suffering from posttraumatic symptoms reported more risk-taking behaviors than nonsymptomatic adolescents. Although there was no gender difference in the degree of exposure to terrorism, boys reported taking more risks than girls. The association between posttraumatic symptoms and risk-taking behaviors was stronger in boys than girls. Functional impairment, gender, avoidance symptoms, level of exposure, and degree of fear predicted the severity of risk-taking behaviors. CONCLUSIONS: Clinicians and educators should be aware of the strong link between posttraumatic distress and risk-taking behaviors. Risk-taking behaviors may be a manifestation of functional impairment and posttraumatic distress, especially for boys exposed to terrorism.

Adolescent↗

PubMed2006

Clinical characteristics and outcome of complicated pneumococcal pneumonia in a pediatric population.

The incidence of complicated pneumonia caused by S. pneumoniae is reported to be increasing. This increase may be related to host susceptibility and/or pathogen virulence. The objective of this study was to evaluate clinical and laboratory characteristics associated with complicated pneumococcal pneumonia, and to identify risk factors associated with prolonged fever and hospitalization. The study involved reviewing the records of all children who were hospitalized in four major hospitals in Jerusalem with a confirmed diagnosis of pneumococcal pneumonia during a 12-year period (1986-1997). Demographic, clinical, laboratory, and outcome variables were compared between those with uncomplicated and complicated pneumonia. One hundred and eleven children (median age, 2.2 years) were hospitalized with pneumococcal pneumonia during the study period. Forty-four (39%) of them had complicated pneumonia, characterized by pleural effusion, empyema, pneumothorax, pneumatocele, and/or atelectasis. There was no correlation between the isolation of penicillin-resistant S. pneumonia (16% of cases) and complicated pneumonia. Factors that were significantly associated with complicated pneumonia included weight <or=10% for age, respiratory distress (e.g., tachypnea, dyspnea), anemia, and a white blood cell count (WBC) <15,000/mm(3) at time of admission. Complicated pneumonia and a WBC <15,000/mm(3) on admission increased the risk for prolonged fever and an extended length of hospitalization. Based on these results, it is concluded that host factors such as anemia, low weight, and a low WBC are associated with complicated pneumonia. Both the presence of pulmonary complications and a relatively low WBC in children hospitalized for pneumococcal pneumonia are independent risk factors for protracted fever and extended hospitalization.

Anemia↗

PubMed2005

Symptomatic urinary tract infections following voiding cystourethrography.

The objective of this study was to assess the frequency of symptomatic urinary tract infections (UTIs) following voiding cystourethrography (VCUG) while using prophylactic antibiotics. Medical records of 421 patients who underwent a VCUG during a period of 4 years were reviewed. Three hundred forty-nine had a VCUG following a febrile UTI, and 72 had the test for evaluation of hydronephrosis. All received prophylactic antibiotics and were evaluated within 7-10 days following the VCUG. One hundred seventy-two children (41%) had an abnormal VCUG. Seven of 421 children (1.7%) had symptoms suggestive of UTI. Two had culture negative pyuria; one had Escherichia Coli UTI, and four had Pseudomonas aeruginosa UTI. On multivariate logistic regression analysis, the risk factors contributing to the development of UTI following VCUG were the presence of vesicoureteral reflux (VUR) and its severity (odds ratio [OR] 2.52; 95% confidence interval [CI] 2.24, 2.83, p =0.001; and OR 2.32; 95% CI 2.05,2.62, p =0.04, respectively). The incidence of VCUG-induced UTI in children receiving prophylactic antibiotic therapy is low. There is a relatively high rate of Pseudomonas UTI, especially in children with moderate to severe reflux. We recommend that children with symptoms suggesting a UTI following a VCUG should be treated for Pseudomonas aeruginosa pending culture results.

Antibiotic Prophylaxis↗

PubMed2004

Familial concordance of phenotype and microbial variation among siblings with CF.

The clinical spectrum of cystic fibrosis (CF) is influenced by the cystic fibrosis transmembrane conductance regulator (CFTR) genotype. However, variable courses of the disease were demonstrated among patients with identical genotypes. Since siblings share identical CFTR mutations and environmental factors, they can serve as a model to assess the effect of modifier genes on disease expression, and also to evaluate cross-infection. The aim of this study was to compare disease expression among siblings with CF. All sibling pairs treated at 7 CF centers in Israel were included in the study. Data were collected from patients' medical charts. Fifty families with at least 2 siblings were identified. As expected, the second-born sibling was diagnosed at an earlier age compared to the first-born. The mode of CF presentation at diagnosis showed significant familial concordance. In the families where the first sibling presented with gastrointestinal manifestations, 79% of the second siblings also presented with gastrointestinal manifestations. When gastrointestinal manifestations were absent in the first sibling, only 12% of the second siblings presented with gastrointestinal manifestations (P < 0.0001). Likewise, when the first sibling presented with respiratory symptoms, 60% of the second siblings presented with the similar symptoms. However, when the first sibling presented without respiratory symptoms, only 12% of the second siblings presented with respiratory symptoms (P < 0.001). Meconium ileus (MI) was present in 20 patients (21%). In 10 families where the first-born sibling had MI, 8 (80%) of the subsequent siblings had MI. On the other hand, in the 39 families where the first-born sibling did not have MI, only 2 (5%) subsequent siblings had MI (P < 0.001). Pancreatic insufficiency (PI) also had high familial concordance (P < 0.0001). Percentile growth for weights and heights and lung function (FVC, FEV(1), and FEF(25-75)) at ages 7 and 10 years were similar between siblings. P. aeruginosa grew from sputum in 89% of our study patients. When P. aeruginosa was isolated from the first-born patient, 91% of the second siblings were also positive for P. aeruginosa, whereas when the initial sibling was not a carrier of P. aeruginosa, only 50% of subsequent siblings were positive (P < 0.0001). This familial concordance was not observed for S. aureus. By contrast, the age of first isolation of P. aeruginosa and S. aureus was significantly earlier in the second sibling than in the first for the two bacteria: 10.3 +/- 5.1 vs. 7.3 +/- 5.2 years (P < 0.05) for P. aeruginosa, and 11.5 +/- 5.4 years vs. 6.8 +/- 5.1 years (P < 0.05) for S. aureus. CF siblings tend to share similar phenotypes that are not mutation-dependent. The lack of variability between siblings in mode of initial CF presentation, rates of MI, pulmonary function, and nutritional status supports the role of modifier genes in the determination of these factors.

Adolescent↗

PubMed2004

Anticipatory postural adjustment in selected trunk muscles in post stroke hemiparetic patients.

OBJECTIVES: To study electromyographic characteristics of anticipatory postural adjustment in axial and lateral, posterior and anterior trunk muscles during the performance of upper-and lower-limb flexion tasks, in subjects with hemiparesis after stroke and to determine the relationship between anticipatory activity and subjects' motor and functional status. DESIGN: A nonrandomized control study. SETTING: Geriatric rehabilitation center in Israel. PARTICIPANTS: Fifty poststroke hemiparetic patients and 30 healthy control subjects. INTERVENTION: Electromyographic activity of the lumbar erector spinae and of the latissimus dorsi muscles was recorded bilaterally during flexion of either arm and from the 2 rectus abdominis and obliquus externus muscles during flexion of either hip. MAIN OUTCOME MEASURES: Muscles' onset latency, cross-correlation values between the temporal activation profile of corresponding pairs and between ipsilateral muscular pairs, symmetry in activation magnitude of corresponding muscles, and relation between electromyographic activity and motor and functional performance RESULTS: Onset latencies of trunk muscles were partially delayed in the patients with longest hindrance displayed by the erector spinae ipsilateral to the flexing arm (P<.04). Temporal synchronization between pertinent muscular pairs was lower in the patients than in the healthy subjects, with significant group differences (P<.05 or lower) in the correlations between ipsilateral pairs of trunk muscles. Activation of the corresponding lateral trunk muscles in the patients was significantly less symmetrical than in the controls (P<.03 or lower) because of reduced activity on the paretic body side, especially on flexing of the paretic limbs. Conversely, in the controls as well as on the nonparetic side of the patients, limb flexion was associated with increased activity in the ipsilateral lateral trunk muscle. The erector spinae muscle in both groups and on both sides was more active on the contralateral side than on the ipsilateral side to the flexing arm. The reduced activity level in trunk muscles on the paretic body side was associated with deficiencies in motor and functional abilities. CONCLUSIONS: Major impairments in the activity of trunk muscles in hemiparetic subjects were manifested in the reduced activity level of the lateral trunk muscles, in delayed onset, and in reduced synchronization between activation of pertinent muscular pairs. These problems were associated with motor and functional deficits and warrant specific consideration during physical rehabilitation of post stroke hemiparetic patients.

Abdominal Muscles↗

PubMed2004

Evaluation of CaDet, a computer-based clinical decision support system for early cancer detection: a comparison with the performance of clinicians.

Based on an analysis of the epidemiologic and clinical attributes of individual patients, the CaDet computer program presents physicians with data patterns that may require clinical attention with regard to early cancer detection. This study evaluated the performance of the program as a possible tool to aid clinicians in the latter. Patient data were obtained by a questionnaire from 160 healthy volunteers. Scored cancer alerts generated by the computer program in response to this data were evaluated in comparison to similar alerts provided by five expert internists who reviewed the same information in blinded fashion. The alert profiles generated by the computer for each of the patients examined were highly correlated to those provided by the clinicians. The computer's alert rate increased with the number of physicians who raised corresponding alerts (20%, 32%, 54%, 73% and 91%, respectively, for 1, 2, 3, 4 and 5 physicians, p < 0.0001) and with the overall weight assigned by the physicians to these alerts (22%, 56%, 84% and 90% for cumulative scores of 1-4, 5-8, 9-12 and 13 or more points, respectively, p < 0.0001). It is concluded that the CaDet computer program may have a role in improving early detection, pending the results of further clinical research.

Decision Support Systems, Clinical↗

PubMed2004

Electromyographic activity of voluntarily activated trunk flexor and extensor muscles in post-stroke hemiparetic subjects.

OBJECTIVE: To study the EMG activity of selected trunk muscles during self-initiated voluntary flexion and extension of the trunk in post-stroke hemiparetic subjects, and to compare measurement results to corresponding findings in control subjects. METHODS: Using a sample of 50 patients and 30 control subjects, bilateral EMG activity of the rectus abdominis (RA) and external oblique (EO) muscles was studied during direct trunk flexion, and activity of the lumbar erector spinae (ES) and latissimus dorsi (LD) was studied during straight trunk extension. Variables of timing, magnitude, and temporal synchronization between muscle activity on the paretic and non-paretic sides of the body in the patient group were compared with the same measurements taken from the left and right sides of the body in the control group. RESULTS: Activity of the RA and LD muscles on the affected side of the body was reduced and delayed relative to the unaffected side in the patients and relative to the control subjects. Some deterioration was also observed in the function of the EO muscle, whereas the lumbar ES displayed normal activity on both sides of the body. Trunk velocity during both flexion and extension was slower in the patients than in the controls. CONCLUSIONS: Despite the existence of ipsilateral as well as contralateral higher inputs to axial and to a lesser extent also to more lateral trunk muscles, the function of the superficial abdominal muscles and of the LD muscle is adversely affected by a contralateral stroke. Conversely, the lumbar ES, which can be categorized as local trunk extensors, seem to normally fulfill their anti-gravitational task on both sides of the body.

Abdominal Muscles↗

PubMed2002

Asthma in adventure travelers: a prospective study evaluating the occurrence and risk factors for acute exacerbations.

BACKGROUND: Exacerbation of asthma during travel to remote regions may lead to devastating consequences. The course of asthma in travelers and the risk factors for disease exacerbation during travel have not been studied. METHODS: We screened 5835 consecutive travelers and identified 203 patients with asthma. Before travel, all enrollees were assessed for presumed risk factors for asthma exacerbation by means of an interview and an exercise test combined with spirometry. After travel, data regarding travel characteristics and asthma severity were recorded by means of a structured telephone interview. RESULTS: The 203 enrollees visited 56 countries for a median duration of 13 weeks, 147 were engaged in high-altitude trekking, and 88 had asthma attacks. Among these, 40 reported worsening asthma during travel, 32 experienced the worst asthma attack ever, and 11 reported a life-threatening asthma attack. Two independent risk factors for attacks during travel were identified: frequent use (> or = 3 times weekly) of inhaled bronchodilators before travel (relative risk [RR], 3.35; 95% confidence interval [CI], 1.75-6.39) and participation in intensive physical exertion during treks (RR, 2.04; 95% CI, 1.04-3.98). When both risk factors were present, the RR for asthma attacks increased to 5.52 (95% CI, 2.81-10.84). CONCLUSIONS: Asthma frequently worsens during travel and should not be ignored as a potentially life-threatening condition requiring pretravel consideration. Asthmatic travelers who frequently use inhaled bronchodilators before travel or participate in intensive trekking during travel are at increased risk to develop asthma attacks. Therapy should be intensified to achieve better disease control; intensive trekking should be discouraged.

Acute Disease↗

PubMed2002

Macrocephaly in children with developmental disabilities.

In a community-based study of 4,309 children with neurodevelopmental disabilities who were referred to the Institute for Child Development, Tel Aviv, Israel, 62 (1.4%) had macrocephaly (head circumference above the ninety-eighth percentile for age), of whom 42 (1%) had macrocephaly not associated with hydrocephalus. With the exception of neonatal respiratory distress the incidence of perinatal complications was not different from that in other children referred to the Institute for Child Development. In children with developmental disabilities, macrocephaly was a significant risk factor for febrile seizures (odds ratio = 3.1, P < 0.001) and epilepsy (odds ratio = 7.7, P < 0.001), but not for mental retardation (odds ratio = 1.1, P = 0.78) or cerebral palsy (odds ratio = 1.3, P = 0.67). Children with macrocephaly had a high rate of comorbid diagnosis. We conclude that in children with developmental disabilities the presence of macrocephaly even when not associated with hydrocephalus is associated with an increased risk of seizures.

Cephalometry↗

PubMed2002

Rate and place of death from asthma among different ethnic groups in Israel: national trends 1980 to 1997.

STUDY OBJECTIVES: To compare the trends of asthma mortality and place of death in young patients (ages 5 to 34 years) from different major population groups in Israel. DESIGN: Retrospective study. PATIENTS AND PARTICIPANTS: Patients who died from asthma between the years 1980 and 1997 according to the death record of the National Israeli Health Registry. RESULTS: During the period studied, 100 asthma mortality cases were reported, which yields a mean mortality rate of 0.226 per 100,000 population. There were no significant changes in the mortality rates over the years. The mean (+/- SD) age of death was 23 +/- 7 years. Of this population, 84.5% were Jews and 15.5% were Arabs, which is proportionate to the general Israeli population. In 52% of the cases, the patients died outside a hospital. There was no significant difference in the place of death between Jews and Arabs. Significantly more men (62.5%) than women (40%) died outside the hospital (p = 0.025). CONCLUSIONS: The asthma mortality rate in Israel during the years 1980 to 1997 was low and stable. Most of the patients still died outside the hospital. There was no difference in the asthma death rate and place of death between Jews and Arabs, suggesting that in our population genetic predisposition is not likely to be a risk factor for mortality.

Age Distribution↗

PubMed2000

Exercise Radionuclide Cineangiography for Predicting Long Term Prognosis in Elderly Post Coronary Artery Bypass Graft Patients.

ISSUE: The immediate benefits of coronary artery bypass grafting may only be transient. Recent studies which showed that exercise radionuclide cineangiography studies may predict cardiac events and survival had evaluated post coronary artery bypass grafting patients of all ages. This prospective study was done on an elderly subgroup. METHODS: The results of exercise radionuclide cineangiography performed early (4-8 months) post coronary artery bypass grafting were correlated over six years of follow up with mortality, major surgical and nonsurgical cardiac events, and cardiac event free survival in 87 consecutive patients at or above 65 years. RESULTS: The rest to peak exercise difference in left ventricular ejection fraction correlated with later cardiac death and the need for surgical interventions, while rest left ventricular ejection fraction correlated only with the latter parameter. CONCLUSIONS: Assessment of left ventricular ejection fraction at rest and at exercise has prognostic values after coronary artery bypass grafting in elderly patients. Exercise radionuclide cineangiography carried out soon after coronary artery bypass grafting might be considered an useful tool to assess patient prognosis. The efficacy of exercise radionuclide cineangiography carried out soon after coronary artery bypass grafting should be confirmed in larger and more varied patient subgroups. (c) 2000 by CVRR, Inc.

Journal Article↗