Biomedical subjects

Yan Press

Publications and source records attributed to Yan Press.

3 recordsLinked to original sources

PubMed2006

Vitamin B12 could be a "master key" in the regulation of multiple pathological processes.

Multifunctional systems must maintain homeostasis. Man is an ideal example of a system that constantly aspires to attain optimal regulation, even under the stress of severe disease. We assume that there are universal, interchangeable (as required) biologically active substances that regulate the system and try to keep it in balance. We propose that one of these substances is vitamin B12. Why vitamin B12? The list of organs and body systems in which vitamin B12 plays a functional role is constantly being added to. Vitamin B12 affects the normal growth of children, the peripheral and central nervous systems, bone marrow, skin, mucous membranes, bones, and vessels. It is possible that even when the serum cobalamin level is normal, treatment with vitamin B12 could correct defects caused by other biologically active substances. We call this phenomenon the "Master Key" effect. We suggest that this "Master Key" concept can be tested by treating diseases, such as recurrent stomatitis, various forms of hyperpigmentation, trophic ulcers, and burns, with vitamin B12, even if the B12 serum level is normal.

Animals↗

PubMed2003

[Sexual dysfunction--what is the primary physicians role?].

BACKGROUND: Sexual dysfunction is characterized by disturbances in sexual desire and/or psycho-physiological changes associated with the sexual response cycle in men and women. Studies suggest that it is prevalent in 10-52% of women and 25-63% of men, and could have a tremendous impact on the individual, interpersonal relations, and on the family quality of life. OBJECTIVE: To assess attitudes, knowledge and sexual dysfunction management by Israeli primary care physicians. METHODS: Two hundred and ninety-two physicians from approximately 800 participants who attended a Family Medicine and General Practice conference took part in the study. A self-reply questionnaire was distributed among the participants and 179 completed the full questionnaire (61%). RESULTS: Seventy nine percent of the physicians thought the primary care physician should be the address for treating most sexual dysfunction problems. Physicians indicated that only 12% of their patients treated for sexual dysfunction were female. Significant differences were found between male and female physicians, board certified family physicians, general practitioners and residents in family medicine regarding sexual dysfunction treatment. Board certified family physicians treated more patients with sexual dysfunctions than general practitioners (GP) and residents in family medicine [53% vs. 23% vs. 22% respectively, (p < 0.05)]. The main barriers for treating sexual dysfunctions noted by physicians were lack of time (62%) and knowledge (47%). CONCLUSIONS: Family physicians consider themselves to be the main address for the patient for sexual dysfunction problems. Physicians believe they need more training to overcome lack of knowledge barriers and they need to organize their time to adequately address their patients sexual dysfunction problems.

Attitude of Health Personnel↗

PubMedDate not supplied

Successful treatment of chronic erythema nodosum with vitamin B12.

A 38-year-old woman presented with painful lesions on both shins that first appeared a few days earlier. Physical examination revealed multiple red tender nodules on both legs. The patient had been treated with nonsteroidal anti-inflammatory drugs for having a few months without any improvement. The patient was referred to a dermatologist and a rheumatologist, who confirmed our diagnosis of chronic erythema nodosum (EN). She returned to the clinic 3 months later complaining of having numbness in the soles of her feet for a few weeks. Her serum vitamin B12 level was 118 pg/mL (normal range 135 to 911). After 4 weeks of twice weekly injections of vitamin B12 at a dose of 1000 mcg, there was a clear alleviation of the numbness, and the EN completely resolved without evidence of recurrence on follow-up. Because it seems that vitamin B12 caused resolution of EN in this case, we recommend that physicians consider testing for vitamin B12 deficiency in patients with EN.

Adult↗