Biomedical subjects

Yao Huang

Publications and source records attributed to Yao Huang.

At least 19 recordsLinked to original sources

PubMed2007

Reductive transformation of parathion and methyl parathion by Bacillus sp.

Based on the results of phenotypic features, phylogenetic similarity of 16S rRNA gene sequences and BIOLOG test, a soil bacterium was identified as Bacillus sp. DM-1. Using either growing cells or a cell-free extract, it transformed parathion and methyl parathion to amino derivatives by reducing the nitro group. Pesticide transformation by a cell-free extract was specifically inhibited by three nitroreductase inhibitors, indicating the presence of nitroreductase activity. The nitroreductase activity was NAD(P)H-dependent, O(2)-insensitive, and exhibited the substrate specificity for parathion and methyl parathion. Reductive transformation significantly decreased the toxicity of pesticides.

Bacillus↗

PubMed2006

An inventory of N(2)O emissions from agriculture in China using precipitation-rectified emission factor and background emission.

Fertilized agricultural soils are a major anthropogenic source of atmospheric N(2)O. A credible national inventory of agricultural N(2)O emission would benefit its global strength estimate. We compiled a worldwide database of N(2)O emissions from fertilized fields that were consecutively measured for more than or close to one year. Both nitrogen input (N) and precipitation (P) were found to be largely responsible for temporal and spatial variabilities in annual N(2)O fluxes (N(2)O-N). Thus, we established an empirical model (N(2)O-N=1.49 P+0.0186 P.N), in which both emission factor and background emission for N(2)O were rectified by precipitation. In this model, annual N(2)O emission consists of a background emission of 1.49 P and a fertilizer-induced emission of 0.0186 P.N. We used this model to develop a spatial inventory at the 10x10km scale of direct N(2)O emissions from agriculture in China. N(2)O emissions from rice paddies were separately quantified using a cropping-specific emission factor. Annual fertilizer-induced N(2)O emissions amounted to 198.89GgN(2)O-N in 1997, consisting of 18.50GgN(2)O-N from rice paddies and 180.39GgN(2)O-N from fertilized uplands. Annual background emissions and total emissions of N(2)O from agriculture were estimated to be 92.78GgN(2)O-N and 291.67GgN(2)O-N, respectively. The annual direct N(2)O emission accounted for 0.92% of the applied N with an uncertainty of 29%. The highest N(2)O fluxes occurred in East China as compared with the least fluxes in West China.

Agriculture↗

PubMed2006

Single-sphere model for absorption spectrum of interfacial molecules with application to predictions of orientational angles.

In this work, a novel expression for nonequilibrium free energy is introduced within the framework of the continuum model. A simple and analytical model for the solvent effect of absorption spectrum of an interfacial molecule is deduced. This model overcomes some lacks existing in the previous theoretical treatments. Associated with the experimental data of N,N-diethyl-p-nitroaniline and 4-(2,4,6-triphenylpyridinium)-2,6-diphenylphenoxide, the present model gives reasonable predication of orientational angles for different interfaces.

Journal Article↗

PubMed2006

Age, outcomes, and treatment effects of fibrinolytic and antithrombotic combinations: findings from Assessment of the Safety and Efficacy of a New Thrombolytic (ASSENT)-3 and ASSENT-3 PLUS.

BACKGROUND: Elderly patients with acute myocardial infarction are at particularly high risk for death and bleeding complications. The efficacy and safety of antithrombotic strategies in these patients remain unclear. METHODS: To provide more insight into the risk and benefit of antithrombotic strategies in the elderly, we examined patients from the ASSENT-3 and ASSENT-3 PLUS trials with STEMI who were treated with tenecteplase (TNK) and unfractionated heparin (UFH) or enoxaparin, or half-dose TNK with abciximab and reduced-dose UFH. RESULTS: Older patients had a higher risk profile, and lower use of concomitant therapies and revascularization procedures. We found an interaction between age and treatment effect for the efficacy end point (P = .0007) and the efficacy plus safety end point (P < .0001). Younger patients (<65 years) had a lower risk of the composite efficacy plus safety end point with enoxaparin (relative risk [RR] 0.84, 95% CI 0.74-0.94) or abciximab (RR 0.79, 95% CI 0.69-0.90) compared with UFH. In patients >65 years of age, the benefit of enoxaparin appeared to be offset by an increased risk of bleeding complications. The risk of the efficacy plus safety end point tended to be higher in elderly patients receiving abciximab and half-dose TNK (RR 1.18, 95% CI 0.91-1.51 for 76-85 years of age and RR 1.48, 95% CI 0.88-2.49 for >85 years of age). CONCLUSIONS: Although TNK with either enoxaparin or abciximab appeared to be more effective than with standard UHF in younger patients, these combinations tended to be less effective and even may be unsafe in the elderly. Development of new combination strategies and dosing schemes of fibrinolytics and antithrombotics with improved efficacy and safety in the elderly remains a high priority.

Aged↗

PubMed2006

Effect of the novel direct factor Xa inhibitor DX-9065a on thrombin generation and inhibition among patients with stable atherosclerotic coronary artery disease.

INTRODUCTION: Thrombin, a pluripotential effector enzyme with prothrombotic, proinflammatory, and mitogenic properties, plays a pivotal role in the pathobiology and clinical expression of atherothrombotic coronary artery disease. Existing anticoagulant drugs have not been shown to attenuate thrombin generation or activity consistently. We sought to investigate the effect of DX-9065a on thrombin generation and inhibition in patients with stable CAD. DX-9065a is a small-molecule, synthetic, direct inhibitor of factor Xa. MATERIALS AND METHODS: Peripheral venous blood samples were collected serially during and after administration of either placebo or 1 of 4 weight-adjusted regimens of DX-9065a, in 73 patients with stable CAD participating in the XaNADU-1B study. RESULTS AND CONCLUSIONS: At baseline, the median (25th, 75th) prothrombin activation fragment 1.2 (F1.2) level was 2.56 (2.05, 3.20) nmol/L, and the median d-dimer level was 0.26 (0.19, 0.38) microg FEU/L. There were significant relationships between measured plasma DX-9065a concentrations and both F1.2 (4.9% decrease for each doubling of DX-9065a) (P<0.0001) and d-dimer (5.5% decrease for each doubling of DX-9065a) (P=0.001). F1.2 was suppressed (below baseline) at 96 h after administration of DX-9065a. Coronary thrombotic events did not occur during or after study drug administration. DX-9065a, the first in a class of small-molecule, direct, selective and reversible factor Xa inhibitors, reduces thrombin generation and fibrin formation among patients with stable CAD. The effect is concentration-dependent and persists for at least 96 h following drug cessation, without biochemical or clinical evidence of rebound.

Aged↗

PubMed2006

[Effects of tillage-cropping systems on methane and nitrous oxide emissions from permanently flooded rice fields in a central Sichuan hilly area of Southwest China].

Using the static opaque chamber method, a field experiment was conducted in situ for two years to study the effects of three cultivation systems on CH4 and N2O emissions from permanently flooded rice fields in a hilly area in Southwest China. The results show that the average CH4 fluxes from a permanently flooded rice field with a single middle rice crop and flooded with no winter crop (PF) were (21.44 +/- 1.77) mg x (m2 x h)(-1) and (3.77 +/- 0.99) mg x (m2 x h)(-1) during rice-growing and non-rice growing periods, respectively, where both values were much lower than many previous reports from similar regions in Southwest China. The annual CH4 emission was mainly occurred in the rice growing period, being only 23.2% of the total annual CH4 flux emitted from the non-rice growing period, though the latter occupied two thirds of a year. The annual average flux of nitrous oxide was (0.051 +/- 0.008) mg x (m2 x h)(-1) and the N2O emission also intensive in the rice growing period. However, being only 8.1% of total annual N2O flux emitted from the non-rice growing period. After implementing the rice-wheat rotation (RW) and rice oil-seed rape rotation (RR), the CH4 emissions were reduced substantially, only 43.8% and 40.6% of those of PF, respectively. However, the N2O emissions were increased after conducting RW and RR systems, which were 3.7 and 4.5 times larger than those of PF. The global warming potentials (GWPs) of the CH4 and N2O emissions under the three tillage-cropping systems were assessed in an integrated way. The results show that the integrated GWPs of the CH4 and N2O emissions are in the following sequence: PF>>RR approximately equal to RR. Within 20, 100 and 500 years spans, the GWPs of the CH4 and N2O emissions of PF were 2.6, 2.1 and 1.7 times larger than those of RW (or RR), respectively. After introducing rice-wheat or rice oil-seed rape rotation systems into the permanently flooded rice fields, the integrated GWPs of the CH4 and N2O emissions were decreased largely.

Air Pollutants↗

PubMed2006

[Effect of organic material incorporation in rice season on N2O emissions from following winter wheat growing season].

In a field experiment, five fertilizer treatments including chemical fertilizer (CF), rapeseed cake + chemical fertilizer (RC + CF), wheat straw + chemical fertilizer (WS + CF), cow manure + chemical fertilizer (CM + CF), and pig manure + chemical fertilizer (PM + CF), were dedicated to examine the effect of organic materials incorporation in the rice season on N2O emissions from the following winter wheat season and to assess the climatic impacts from CH4 and N2O emissions in a rice-wheat rotation. Organic material was incorporated at the same rate (225 g x m(-2)) for organic treatments at the depth of 10 cm in the soil as the basal fertilizer just before rice transplanting. An identical synthetic nitrogen fertilizer was adopted for all treatments. Results show that the seasonal amount of N20 emissions from the following wheat season differed with organic material applied in rice season. No pronounced difference in N20 emissions was found between the CF and RC + CF treatments. In contrast with the CF treatment, however, N2O emission was decreased by 15% for the WS + CF treatment, but increased by 29% and 16% for the CM + CF and PM + CF treatments, respectively. Over the entire annual rotation cycle, N2O amount was increased by 17% for the CM + CF treatment, 7% for the PM + CF treatment, and 6% for the RC + CF treatment, but decreased by 16% for the WS + CF treatment in comparison with the CF treatment. Based on total emissions of CH4 in rice season and N2O over the entire rotation cycle, the estimation of combined Global Warming Potentials (GWPs) for CH4 and N20 shows that over a 20 years horizon or a 500 years horizon, the value of annual total GWPs was ranked in the order of RC + CF > WS + CF > CM + CF > PM + CF > CF or RC + CF > CM + CF > PM + CF > WS + CF > CF. The highest, middle and the lowest value of the GWPs per unit crop grain yield occurred for the crop residue, farmyard manure and pure synthetic fertilizer treatments, respectively. Compared to the chemical fertilizer treatment, accordingly, organic material combined with chemical fertilizer application in rice season increased climatic impacts from CH4 and N20 emissions in a rice-winter wheat rotation system.

Agriculture↗

PubMed2006

[Study on mechanism of enhanced UV-B radiation influencing on N2O emission from soil-winter wheat system].

To study the influencing mechanisms of enhanced UV-B radiation on the emission of N20 from soil-wheat system, outdoor pot experiments with simulating 20% supplemental level of UV-B were conducted. Results indicate that the enhanced UV-B had no significant impact on the emission of N20 from soil-wheat system in turning- green stage, but declined the N2O flux and the rate of the system's respiration in elongation stage. The impact mechanisms of enhanced UV-B radiation on the N2O flux were to directly change the nitrogen metabolism process of wheat plant, such as significantly increasing soluble protein, total nitrogen and total phosphorus in wheat leaves. But the effects of UV-B radiation on soil N2O emission may be indirect, namely, UV-B treatment by working on wheat plant significantly increased the soil available nitrogen, soil microbial biomass C and N, and also changed the ratio of soil microbial C: N(from 5.0 to 6.8) in winter-wheat rhizosphere.

Biodegradation, Environmental↗

PubMed2005

Extent of ST-segment depression and cardiac events in non-ST-segment elevation acute coronary syndromes.

AIMS: We sought to determine whether the extent of myocardial ischaemia on the admission electrocardiogram (ECG) has independent predictive value for short-term risk stratification of patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS). Although the presence of ischaemic ECG changes on admission has been shown to predict outcome, the relationship between the extent of ECG changes and the risk of cardiac events is still ill defined. METHODS AND RESULTS: We analysed the admission ECGs of 5192 ACS patients enrolled in the GUSTO-IIb trial, without an ECG indication for thrombolysis. ECG tracings showing one or more of the following were eligible: ST-segment depression >0.5 mm, T-wave inversion >1 mm, and ST-segment elevation >0.5 mm but <1 mm. ECG variables associated with unfavourable 30 day outcomes in a univariable analysis were further assessed in a multivariable logistic regression model including independent clinical predictors. In the multivariable clinical, enzymatic, and ECG model, the sum of ST-segment depression (in millimetres) in all leads was a powerful independent predictor of 30 day death (P<0.0001), with a continuous increase in risk with the extent of ST-segment depression. The sum of ST-segment depression (P<0.0001) and the presence of minimal inferior ST-segment elevation (P<0.0001) or anterior ST-segment elevation (P=0.0182) were also independent predictors of the composite of death and myocardial infarction or reinfarction. The extent of ST-segment depression showed a highly significant correlation with the prevalence of three-vessel (P<0.0001) or left main coronary disease (P<0.0001), and also with the peak levels of creatine kinase (P<0.0001) during the index episode of ACS. CONCLUSION: In patients with NSTE ACS, the sum of ST-segment depression in all ECG leads is a powerful predictor of all-cause mortality at 30 days, independent of clinical variables and correlates with the extent and severity of coronary artery disease. The presence of even minimal (<1 mm) ST-segment elevation in anterior or inferior leads is independently associated with adverse outcomes.

Acute Disease↗

PubMed2005

Effects of copper concentration on methane emission from rice soils.

Outdoor pot experiments with various paddy soils representing five soil types were conducted at Nanjing Agricultural University during the 2000 and 2001 rice-growing seasons. Eighteen soils and ten out of the eighteen soils were involved in the 2000 and the 2001 experiment, respectively. Two treatments were designed as mineral fertilization (MF) and mineral fertilizer + wheat straw incorporation (MF + WS) for the 2001 experiment. Seasonal average rate of CH4 emission from different soils ranged from 1.96 to 11.06 mg m(-2) h(-1) in the 2000 experiment, and from 0.89 to 5.92 mg m(-2) h(-1) for the MF treatment in the 2001 experiment, respectively. Incorporation of wheat straw enhanced considerably CH4 emission with an average increment of 7.09 mg m(-2) h(-1). CH4 emissions from the two-year experiment were negatively correlated to soil available and total copper concentration. A further investigation showed that CH4 emission from the MF treatment was positively related to the dissolved organic carbon (DOC) in the soil (r = 0.904, p < 0.001), and that the DOC was negatively correlated to the concentrations of available copper (r = -0.844, p < 0.01) and total copper (r = -0.833, p < 0.01), respectively. Nevertheless, the incorporation of wheat straw did not enhance the soil DOC, and the relationship between CH4 emission and soil DOC was not statistically significant (r = 0.470, p < 0.20). It was concluded that higher concentration of copper in the soils resulted in lower soil DOC and thus reduced CH4 emission when there was no additional organic matter input. Incorporation of wheat straw did not affect soil DOC and available copper concentration but enhanced CH4 emission.

Carbon↗

PubMed2005

[CH4 and N2O emission from a winter-time flooded paddy field in a hilly area of Southwest China].

By the method of static opaque chamber/modified gas chromatography, a one-year field experiment was conducted to measure in situ the CH4 and N2O emission from a winter-time flooded paddy field in a hilly area of Southwest China. Gas samples were taken simultaneously from rice-involved and rice-uninvolved plots. The results showed that during rice growth period, the CH4 emission from the winter-time flooded paddy field was higher than that from other paddy fields, but largely lower than many previous reports for the similar regions in Southwest China. The average flux of CH4 emission from rice-involved plots was 22.76 +/- 2.76 mg CH4 x m(-2) x h(-1) during rice growth period, 9.64 +/- 1.17 mg CH4 x m(-2) x h(-1) per year, and 1.43 +/- 0.20 mg CH4 x m(-2) x h(-1) during non-rice growth season; while that from rice-uninvolved plots was only 2.03 +/- 0.18 mg CH4 x m(-2) x h(-1) per year, markedly lower than those from rice-involved plots. During rice growth season, the mean emission rate of CH4 and N2O was 4.53 +/- 0.38 mg CH4 x m(-2) x h(-1) and 32.01 +/- 5.02 microg N2O x m(-2) x h(-1) from rice-uninvolved plots, but reached to 22.76 +/- 2.76 mg CH4 x m(-2) x h(-1) and 73.04 +/- 5.03 microg N2O x m(-2) x h(-1) from rice-involved plots, respectively. Rice involvement resulted in 302% increment of CH4 and 128% increment of N2O emission. There was a clear trade-off between CH4 and N2O emission in paddy fields. Even with a span of 500 years, our calculation showed that in this winter-time flooded paddy field, the GWP contributed by N2O production was 7.9% of the CH4 contribution, and thus, the greenhouse effect of N2O production from this field was very small.

Greenhouse Effect↗

PubMed2005

[Simulating net primary production of rice and wheat crops: model establishment].

On the basis of the principles of plant physiology, agro-meteorology and soil environment, net primary production of rice and wheat crops was modeled. The model includes two main functional modules: photosynthesis and respiration, and nitrogen transport within soil-plant system. The processes of photosynthesis and respiration are driven by environmental variables and plant nitrogen content. The transportation of nitrogen within soil-plant system is determined by simulating the processes of crop nitrogen uptake, soil nitrogen mineralization and synthetic nitrogen release.

Biomass↗

PubMed2005

[Simulating net primary production of rice and wheat crops: model validation and scenario prediction].

A model developed by the authors was validated against a total of 98 independent data sets to simulate net primary production (NPP) of rice and wheat crops. These data sets come from literature review and include field measurements conducted in different regions of China with various rates of N application. Model validation indicates that NPP of rice and wheat crops in main cultivated-area of China can be well simulated from weather, soil and N fertilization. A comparison between the simulated (y) and the observed NPP (x) resulted in a regression of y = 1.05x- 16.8 (r2= 0.771,p < 0.001, n = 98). Model scenario prediction for Nanjing area suggests that the increase of atmospheric CO2 concentration will enhance carbon fixation, while the increase of air temperature will reduce carbon fixation by rice and wheat crops. Effect of global warming on the wheat carbon fixation is less than on the rice. Under present and future scenario with atmospheric CO2 concentration of 540 micromol x mol(-1) and temperature increment of 1-4 degrees C, N fertilization will enhance carbon fixation of rice and wheat crops. The enhancement for wheat is more significant than that for rice crop. However, the application of N will not significantly improve the carbon fixation, even reduce rice NPP when the N application rate is higher than 150 kg x hm(-2).

Biomass↗

PubMed2005

[The diagnostic value of dynamic CT in solitary pulmonary nodules: a prospective study].

OBJECTIVE: To evaluate imaging features of benign and malignant solitary pulmonary nodules (SPN) using dynamic computed tomography (dCT) to improve the accuracy of radiological diagnosis. METHODS: Fifty-one patients with SPN were studied by dCT. In this procedure, a bolus of 100 ml contrast medium was administrated intravenously at a rate of 4 ml/sec. The same-located dynamic scans were carried out from 15 sec to 120 sec following the injection. Time-attenuation curves (TAC) were created according to circular or oval ROI drawn over nodules. Histopathological diagnosis was considered as the golden standard in all patients. Double-blind examination and evaluation were carried out and the data were analyzed statistically with Mann-Whitney U test. RESULTS: Thirty eight cases were diagnosed to be malignant SPN (mSPN) and 13 cases to be benign SPN (bSPN). The benign SPN were further divided into two groups, bSPN(1) consisting 6 cases with chronic pneumonitis, nodular tuberculosis or sclerosing hemangioma and bSPN(2) consisting 7 cases with tuberculoma, pulmonary cyst, pulmonary sequestration or mycosis ball. There were statistically significant differences between mSPN and bSPN(2) in peak heights of enhancement (87.6 HU vs. 57.8 HU, P < 0.01), enhancement values (peak heights- unenhanced CT values, 59.6 HU vs. 11.1 HU, P < 0.01). However, no statistically significant differences of those two values existed between mSPN and bSPN(1). TAC of mSPN reached to peak height more rapidly and remained a plateau. TAC of bSPN(1)s showed similar changes to that of mSPN despite a delayed reach to a peak height or even a descending branch. TAC of the bSPN(2)s was lower and flatter without peak height. If a threshold of 20 HU was taken for dCT, the lesions with < or = 20 HU were diagnosed as benign, and the lesions with > 20 HU were diagnosed as malignant, with a sensitivity of 100%, a specificity of 54.0% and an accuracy of 88.4%. CONCLUSION: (1) Absence of the marked enhancement (< or = 20 HU) in dynamic CT is strongly predictive of benignancy. (2) The peak height and enhancement value of dCT are helpful to differentiate malignant SPNs from benign ones. (3) The TAC configuration is helpful in differentiating malignant SPNs from benign ones. Descending branches could be found in some benign lesions, but not in the malignant ones. The TAC of tuberculoma and mycosis ball is usually relatively low and flat without any peak height.

Adenocarcinoma↗

PubMed2005

[Impact of different levels of nitrogen fertilizer on CH4 emission from different paddy soils].

To investigate the effect of different urea incorporation amount in different soils on CH4 emission, a pot experiment was carried in 2002. Four treatments were designed as the control (without urea incorporation); low N fertilizer level (0.64 g urea/pot); middle N fertilizer level (1.28 g urea/pot); high N fertilizer level (1.93 g urea/pot). During rice growing season, incorporation of urea into different soils yielded different influence on CH4 emission. Without urea incorporation, significance differences existed among CH4 emission flux of three soils, with the values of 6.7 g/m2, 12.6 g/m2 and 8.3 g/m2, respectively. Incorporation of urea reduced considerably CH4 emission of three soils. A further investigation indicate that CH4 emission of three soils largely decreased and three soils NH4(+)-N content obviously increased from low N fertilizer level to middle N fertilizer level. It concluded that soil NH4(+)-N content is a key influence factor on CH4 emission after incorporation of urea into soils. From middle N level to high N level, CH4 emision of soil G (Lianshui, Jiangsu) and H (Jiangsu Academy of agricultural sciences) reduced, while CH4 emission of soil F (Lishui, Jiangsu) had no obvious significance with the value of 3.0 g/m2 and 3.4 g/m2.

Air Pollutants↗

PubMed2005

[Effects of aluminum speciation on wheat root growth and its enzyme activity].

Aluminum speciation is recognized to associate with environmental pH. In this paper, the effects of aluminum speciation (A1a, A1b) on the growth, protein content, acid phosphatase (AP) activity of wheat root were studied by changing the pH of aluminum solutions. Two concentrations of total aluminum, 25 micromol x L(-1) (T1) and 75 micromol x L(-1) (T2), were set up in the test solutions, and four levels of pH, 4.0, 4.5, 5.0 and 5.5, were regulated for each solution. The results indicated that the growth of wheat root in T1 and T2 was strongly inhibited by low doses of Ala and Alb, while the changing trend of protein content and AP activity varied when exposed to different composition of active A1. When the A1a concentration was above 90% of the active Al concentration, the protein content was reduced while the AP activity was enhanced by Al at pH 4.0, but it was reverse at pH 5.0 when the concentration of Ala and Alb was below 10 micromol x L(-1), respectively.

Acid Phosphatase↗

PubMed2005

[N2O emission factor for agricultural soils].

Based on the direct measurements of annual N2O emission from 207 field experiments reported in literatures between 1982 and 2003, this paper established a database of annual N2O emission from agricultural fields. Correlation analysis indicated that the N2O emission from agricultural soils was significantly correlated with climatic factors temperature and precipitation, while no significant correlations were observed between N2O emission and edaphic parameters pH, organic carbon and nitrogen. According to the definition of N2O-N emission factor and its quantification by the Intergovernmental Panel on Climate Change, the N2O-N emission factor was modified by annual mean temperature and annual precipitation, respectively. The results suggested that the modification with precipitation might significantly reduce the estimated error of N2O emission by about 16%, while that with temperature did not reduce the error, in comparison with the default emission factor by the Intergovernmental Panel on Climate Change.

Crops, Agricultural↗

PubMed2004

Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy.

Fatty acid oxidation (FAO) is a primary energy source for meeting the heart's energy requirements. Peroxisome proliferator-activated receptor-delta (PPAR-delta) may have important roles in FAO. But it remains unclear whether PPAR-delta is required for maintaining basal myocardial FAO. We show that cre-loxP-mediated cardiomyocyte-restricted deletion of PPAR-delta in mice downregulates constitutive expression of key FAO genes and decreases basal myocardial FAO. These mice have cardiac dysfunction, progressive myocardial lipid accumulation, cardiac hypertrophy and congestive heart failure with reduced survival. Thus, chronic myocardial PPAR-delta deficiency leads to lipotoxic cardiomyopathy. Together, our data show that PPAR-delta is a crucial determinant of constitutive myocardial FAO and is necessary to maintain energy balance and normal cardiac function. We suggest that PPAR-delta is a potential therapeutic target in treating lipotoxic cardiomyopathy and other heart diseases.

AMP-Activated Protein Kinases↗