Biomedical subjects

Yashpal

Publications and source records attributed to Yashpal.

10 recordsLinked to original sources

PubMed1999

Cyclosporine trough levels in renal graft recipients.

Blood Trough Levels (TL) of cyclosporine (CyA) [the drug panimun bioral cyclosporine oral solution USP--modified. Panacea Biotec Ltd], were monitored in 103 renal transplant patients who were receiving CyA orally. Two hundred and sixty-two blood concentrations of CyA were determined using a validated HPLC assay over a period of two years. Mean dose from week 1 until 2 years ranged from 7.65 +/- 0.9 to 2.73 +/- 0.8 mg/kg. Mean blood CyA levels ranged from 197.4 +/- 87.5 to 205.9 +/- 113.5. The TL concentration changes versus dose reduction were not markedly different after 2-4 weeks and remained within therapeutic range. Stabilised concentrations were achieved after first month. We conclude that the blood TL of CyA were in the nominal therapeutic range suitable for renal transplant patients.

Cyclosporine↗

PubMed1995

Renal failure in acute pancreatitis.

Twenty six (7.3%) of a total of 356 patients with acute renal failure were found to have acute pancreatitis as the primary disease. Seventeen (65.4%) of them were males. Their mean age was 35.6 years. Clinically epigastric pain and tenderness were seen in all (100%); nausea vomiting (73%), low grade fever (50%), left sided pleural effusion (38.4%), haemopericardium (26.9%), shock (26.9%), pseudocyst (19.3%) and adult respiratory distress syndrome (7.6%) were the other major presenting features. Serum amnylase (100%), lipase (53.8%), triglycerides (53.8%) and blood sugar (38.5%) were raised in majority whereas serum calcium was detected to be below normal in 46.2% patients. Blood urea and serum creatinine were raised in all and hyperkalacmia was found in 50% patients. CT scan and USG abdomen showed bilateral enlarged kidneys (100%), pancreatic oedema (80.7%), necrosis of pancreas (19.3%) and pseudocyst (19.3%). Management included repeated peritoneal dialysis in all (100%) and surgical intervention in 53.8% patients with severe necrotising and haemorrhagic pancreatitis. All patients recovered from acute renal failure, but 26.9% patients expired due to complications of acute pancreatitis other than acute renal failure.

Acute Disease↗

PubMed1985