Biomedical subjects

Yi-Chin Fong

Publications and source records attributed to Yi-Chin Fong.

6 recordsLinked to original sources

PubMed2006

Nerve sheath ganglion of the tibial nerve presenting as a Baker's cyst: a case report.

Nerve sheath ganglion is a relatively rare clinical entity commonly found in the peroneal nerve in the lower limb or the ulnar nerve in the upper extremity. It is rarely found in the tibial nerve. The occurrence of a nerve sheath ganglion in a patient's tibial nerve has been identified. The initial presentation of the tumor mass has been very similar to that of a Baker's cyst, namely a soft undulating popliteal mass. Yet, the case also presented symptoms and signs of tibial nerve compressive neuropathy. We present here a rare case of nerve sheath ganglion of the tibial nerve. Clinical courses of the patient were reviewed, and relevant issues were discussed with a thorough literature review.

Adrenal Cortex Hormones↗

PubMed2006

Mucoid degeneration of the anterior cruciate ligament.

We report 2 cases of mucoid degeneration of the anterior cruciate ligament (ACL). Mucoid degeneration of the ACL is a very rare cause of knee pain. The first patient presented with extension block of the knee, and the second patient had simple knee pain. Both patients did not have obvious trauma history or clinical instability of the knee. After arthroscopic debridement of the lesion, both patients regained full range of motion of the knee and were pain-free at follow-up. Mucoid degeneration of the ACL is suspected when an apparently thickened and ill-defined ligament with increased signal intensity on all sequences in magnetic resonance imaging is identified in a patient with physically intact ligament and no obvious trauma history. Arthroscopic debridement of the mucoid degeneration of the ACL was safe and effective in these 2 patients.

Anterior Cruciate Ligament↗

PubMed2005

Intrapelvic migration of a Kirschner wire.

Intrapelvic migration of a Kirschner wire, used in the treatment of hip fracture, is rare. We report a case of intrapelvic migration of a Kirschner wire 10 years after its placement. Even though the patient was asymptomatic, we proceeded to remove the migrated wire using laparoscopic techniques. Given the increasing number of hip operations being performed, and given that intrapelvic foreign bodies can result in serious or fatal complications, it is important to keep this problem in mind in patients who have had previous hip surgery.

Aged↗

PubMed2004

Absence of a correlation between the presence of a single nucleotide polymorphism in the matrix metalloproteinase 1 promoter and outcome in patients of chondrosarcoma.

PURPOSE: Increased levels of matrix metalloproteinase 1 (MMP-1) expression have been associated with poor outcome in chondrosarcoma. The existence of a single nucleotide polymorphism creating an Ets-binding site in the MMP-1 promoter may be one mechanism for elevated MMP-1 transcription. The aim of our study was to identify the prevalence of this single nucleotide polymorphism (SNP) in chondrosarcoma patients, to determine its correlation with disease outcome, and to discern whether it could serve as a prognostic marker in patients with chondrosarcoma. EXPERIMENTAL DESIGN: Sixty-seven chondrosarcoma specimens were selected sequentially from an established tumor bank with a median duration of 47 months follow-up (range, 24 to 179 months). DNA was extracted, amplified with PCR, and sequenced to determine presence (GG) or absence of the Ets-binding site created by the SNP. RESULTS: Eighteen (27%) samples were homozygous for the absence of the Ets site, 34 (51%) were heterozygous for the SNP, and 15 (22%) were homozygous for the SNP. The 5-year overall survival rate for patients was 78, 80, and 84%, respectively (P = 0.5527). The disease-free survival rate was 16, 63, and 76%, respectively (P = 0.0801). The 5-year disease-free survival rate for patients with the homozygous G/G genotype was 16%, compared with 71% for patients who were either homozygous or heterozygous for the GG allele (P = 0.0444). CONCLUSIONS: Despite a statistical correlation between MMP-1 gene expression and outcome in chondrosarcoma, this study demonstrates an absence of a correlation between the presence of the SNP and prognosis in patients with chondrosarcoma.

Adult↗

PubMed2004

Chondrosarcoma of the chest wall: a retrospective clinical analysis.

Primary chondrosarcoma of the chest wall is uncommon, and reports of treatment from one institution are limited. Treatment of this lesion is difficult because of the anatomic location, which is in close proximity to surrounding neurovascular and visceral structures. The purpose of this study was to review the outcome of surgical resection of chondrosarcoma of the chest wall, and to delineate the prognostic factors related to local recurrence and survival. Twenty-four patients with chondrosarcoma of the chest wall were treated at our institution between 1986 and 2000. There were 14 males and 10 females, with an average age of 54 years (range, 11-76 years). Patients were observed for a minimum of 3 years or until death. The median followup was 71 months. The anatomic locations of chondrosarcoma of the chest wall were the rib in 16 patients, the ribs and sternum in two patients, the ribs and spine in three patients, and the sternum only in three patients. Histologically, 17 patients had Grade 1 disease and seven patients had Grade 2 disease. At followup, 17 patients were alive without disease, two were alive with disease, two died without disease, and three died secondary to progressive disease. The overall survival estimate at 5 years was 92%. The recurrence rate for patients with adequate surgical margins was 10%, compared with 75% for patients with inadequate margins. The 5-year survival rate for patients with adequate surgical margins was 100%, compared with 50% in patients with inadequate surgical margins. An inadequate margin of resection was associated with a significantly worse overall survival and a higher chance of having local recurrence develop.

Adolescent↗

PubMed2003

Extraskeletal mesenchymal chondrosarcoma.

Extraskeletal mesenchymal chondrosarcoma is a rare malignancy. It is characteriged by a bimorphic histologic pattern, with a mesenchymal tissue mixed with malignant hyaline cartilage. It also has high incidence of local recurrence and distant metastasis. All cases have been reported fatal associated with this tumor in spite of complete surgical excision. A 35-year-old female presented with a palpable mass about 5 x 3 x 2.5 cm3 in size over her left forearm and was reported to be an extraskeletal mesenchymal chondrosarcoma. Marginal resection followed by regional radiotherapy was done. No local recurrence or distant metastasis was found two years after surgery. Thorough physical examination, series radiographic studies, and multiple sites of tumor biopsies before radical resection of the tumor may decrease the misdiagnostic rate for extraskeletal mesenchymal chondrosarcoma. Appropriate tumor treatment, close patient follow-up and timely treatment for local recurrence or distant metastasis may increase the survival rate.

Adult↗