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Yi-ming Zhao

Publications and source records attributed to Yi-ming Zhao.

18 recordsLinked to original sources
PubMed2006

[Adjustment of dose-response relationship of industrial impulse noise induced high frequency hearing loss with different exchange rate].

OBJECTIVE: To explore a new method to evaluate the dose-response relationship between the noise exposure and prevalence of noise induced high frequency hearing loss. METHODS: Physical examination and questionnaire survey were conducted among 32 mechanical workers, 12 males and 20 females, aged 35.1 +/- 7.2, exposed to industrial impulse noise (impulse noise group), and 163 textile workers, 82 males and 81 females, aged 31.5 +/- 8.7, exposed continuous noise (continuous noise group). SH-126 dosimeter was used to measure the A weighted equal sound level in continuous eight working hours (L(Aeq.8h)) so as to evaluate the individual noise exposure. Cumulative noise exposure (CNE) was calculated with the values of L(Aeq.8h) and noise working year adjusted by different exchange rates (ERs) for each worker. Hearing threshold was measured by audiometer with routine method and adjusted by age and gender according to GBZ49-2002. High frequency hearing loss was diagnosed based on the GBZ49-2002 for each worker. RESULTS: According to the equal energy rule, with the ER = 3 the CNE of the impulse noise group was [103.2 dB (A).year +/- 4.2dB (A).year], significantly lower than that of the continuous noise group [110.6 +/- 6.0 dB (A).year, P < 0.05]. With the ER = 5.5, the CNE of the impulse noise group was 110.3 +/- 6.6 dB (A).year, not significantly different from that of the continuous noise group [110.6 +/- 6.0 dB (A).year]. The high frequency hearing loss prevalence of the impulse noise group was 68.8%, not significantly different that of the continuous noise group (65%, P > 0.05). Trend chi square test showed significant differences in the relationship between CNE and hearing loss prevalence among the impulse noise group with the ER = 3, the impulse noise group with the ER = 5.5, and continuous noise group (all P < 0.01). With the ER = 3, the high frequency hearing loss prevalence of the impulse noise group with the CNE of 100-104 dB (A).year was 76.9%, significant higher than that of the continuous noise group (30.4%, P < 0.05); and the high frequency hearing loss prevalence of the impulse noise group with the CNE of 105-108 dB (A).year was 90.9%, significantly higher than that of the continuous noise group (50.0%, P < 0.05). With the ER = 5.5, there was no difference in the prevalence of high frequency hearing loss between the continuous noise group and impulse noise group. Logistic regression model showed that with the ER = 3, the dose-response curve of the impulse noise group presented a left shift and with a slope sharper than that of the continuous noise group. With the ER increasing the dose-response curve of the impulse noise group showed a right shift and with a gradually lowering slope. When the ER equaled to 6 in the impulse noise group and equaled to 3 in the continuous noise group, the two dose-response curves were almost superposed. CONCLUSION: Impulse noise causes more serious damage in causing high frequency hearing loss than continuous noise according to equal energy rule. Increasing the ER value in the impulse noise group adjusts the dose-response curve to be close to that of the continuous noise group.

Adult↗
PubMed2006

[Measurement of personal noise exposure in a cold rolling mill].

OBJECTIVE: To measure and evaluate the personal noise exposure of cold rolling mill workers by using noise dosimeter. METHODS: According to job category and work type, all workers were divided into 11 groups. 3 to 5 day shift (8:00 to 16:00) workers from each group were selected as subjects for personal noise exposure measurement. SH-126 dosimeters were worn by each subject and collect noise data by a phone fix at collar. All subjects were asked to take notes about their working activities when they were wearing SH-126 dosimeters. Each worker's L(A)(eq) of 8 hours, geometric mean and range of each group were computed. RESULTS: There were many noise sources in the workshop. Recorded data showed that noise exposure of cold rolling mill was unstable. The varieties of personal noise levels were quite large. Among 53 workers, the highest noise exposure level was 100.0 dB (A), the lowest was 81.2 dB (A); the highest work type was of the foreside welders [94.20 dB (A)], and the lowest was of the straight-cutters [89.02 dB (A)]; quality checkers had the biggest rang [16.3 dB (A)], and primary rolling workers had the lest [2.3 dB (A)]. CONCLUSION: Noise exposure of all the 11 groups were more than 85 dB (A). Noise protection of these workers should be improved. It suggested that measuring personal noise exposure individually with dosimeters might obtain the noise exposure level more integrally in the complicated environment.

Environmental Monitoring↗
PubMed2006

[Efficacy of Betahistine Mesilate combined with Flunarizine Hydrochloride for treating tinnitus].

OBJECTIVE: To determine whether Betahistine mesilate is effective in treating tinnitus. METHODS: Randomized, prospective, double-blind, controlled trial was used in our study. The study group consisted of 60 adult patients who consulted our outpatient clinic complaining of subjective tinnitus, excluded objective tinnitus and the patients who had tinnitus caused by obvious diseases, such as outer and middle ear diseases. Thirty patients were given Betahistine mesilate and Flunarizine Hydrochloride as an experimental group, 30 patients were given Vitamin B6 and Flunarizine Hydrochloride as a control group. After a week of treatment the efficacy of the medicines in two groups was observed. Tinnitus questionnaire was performed before the treatment, and pure tone audiogram, tinnitus pitch and loudness matching were performed both in the beginning and at the end of the treatment. RESULTS: Completion of treatment, tinnitus loudness matching assessment showed that the efficacy of the Betahistine mesilate group was better then the control group. The efficacy of treatment was respectively 65.5% by per protocol (PP) and 63.3% by intend to treat (ITT) in the Betahistine mesilate group and 39.3% by PP and 36.7% by ITT in the control group. The difference of tinnitus loudness improvement rate between the experimental group and control group was statistically significant. But the subjective tinnitus improvement rate showed no difference between two groups. There were not serious side effects in the two groups. CONCLUSIONS: Betahistine mesilate can be a choice for tinnitus treatment clinically. Further studies of larger series and placebo-controlled trial are needed.

Adolescent↗
PubMed2006

[Water exposure modes and times of different populations in mountainous schistosomiasis endemic areas near Qionghai lake].

OBJECTIVE: To investigate water exposure modes and times of different populations in mountainous schistosomiasis endemic areas and to inform about the control strategies. METHODS: All 1054 residents from populations around Qionghai Lake were randomly sampled according to occupation for a retrospective questionnaire survey in November 2001. Each individual was interviewed for his/her mode, frequency, and duration of water exposure occurring between April and October 2001. RESULTS: The average exposure times and intensity were higher in farmers (median: 16 - 18 min/day and 2.41 - 2.5, respectively) who grow rice, tobacco, and vegetables than others (median: 3.74 - 7.39 min/day and 0.81 - 1.52, respectively); exposure frequency was found highest in farmers (median: 2.04 times/day) in all occupations; schoolchildren had low exposure frequency and times, but very high exposure intensity (median 2.34). Between April and June it is an agriculturally busy season, that is also a peak season of water exposure of adults. Schoolchildren's water exposure peaks on July and August, mainly due to playing water and swimming. Exposure times and intensities were higher in females than in males. CONCLUSION: Water exposure modes, times, and intensities of different populations were different in mountainous schistosomiasis endemic areas of Xichang. Between April and June should be the peak infection season of adults who are engaging in agricultural activities, while July to August should be the peak infection season for schoolchildren with non-agricultural activities.

Adult↗
PubMed2006

[Relationship between sample size and variation of means for personal noise exposure in weaving workers].

OBJECTIVE: To explore the relationship between sample size and variance of means for personal noise exposure in weaving workers as to contributing evidence for establishing personal noise exposure measurement guideline. METHODS: A personal noise exposure measurement database from a group of weaving workers was used in the randomized re-sampling data analysis. The sampling cases were one number selecting from one to fifteen at each randomized re-sampling procedure. The randomized re-sampling was one thousand times from original personal noise exposure measurement database to get one thousands of re-sampling database. One thousands of L(Aeq.8 h) mean were calculated by re-sampling databases. The variation of randomized re-sampling means was analyzed for different re-sampling numbers. RESULTS: The change for narrow trend of maximum, minimum, 95 percent number, 5 percent number of L(Aeq.8 h) mean was faster when randomized re-sampling number was smaller in variation vs randomized re-sampling number curve analysis. After that, the change for narrow trend of L(Aeq.8 h) mean was smooth for increasing the randomized re-sampling numbers. The 95% - 5% of L(Aeq.8 h) mean was about half for randomized re-sampling four cases (3.30 dB) vs one case (7.40 dB), and about one third for seven cases (2.44 dB), and about one fourth for eleven cases (1.85 dB). CONCLUSION: The sample size in personal noise exposure measurement guideline could be selected from four to eleven.

Humans↗
PubMed2005

[Prediction of 2-year outcome by combining TIMI myocardial perfusion grading with sum ST segment resolution in patients with acute myocardial infarction].

OBJECTIVE: To evaluate the value of combining TIMI myocardial perfusion (TMP) grading with sum ST segment resolution (sumSTR) in prediction of the 2-year outcome and heart function in patients with acute myocardial infarction (AMI) after emergency percutaneous intervention (PCI). METHODS: Seventy-seven consecutive patients of AMI with elevated ST segment, 62 males and 15 females, aged 63 +/- 12 (30-91), underwent PCI. TMP grading was used in combination of electrocardiography to calculate the sumSTR so as to evaluate the effect of myocardial reperfusion. The patients with TMP grade 2-3 and sumSTR > or = 30% were included in the group of better perfusion, and those with the TMP grade 0-1 and sumSTR < 30% were included in the group of lower perfusion. The cardiac events, including death, reinfarction, revascularization, angina pectoris, and heart failure were recorded. The left ventricular end-diastolic dimension (LVEDD) and left ventricular ejection fraction (LVEF) were measured by echocardiography 72 hours and 2 years after the PCI. RESULTS: There were 37 patients in the lower perfusion group and 39 patients in the better perfusion group. Cos regression showed that TMP grade 0-1 associated with sumSTR < 30% was an independent factor for 2-year cardiac events (RR = 13.186, 95% CI 2.149 - 80.917, P = 0.005). The LVEDD 2 years after PCI was 60 mm +/- 4 mm, significantly higher than that 72 hours after PCI (53 mm +/- 4 mm. P < 0.01) in the lower perfusion group. The LVEDD increased by 7.1 mm +/- 1.9 mm two years after PCI in the lower perfusion group, significantly more than that in the better perfusion group (1.5 mm +/- 1.2 mm, P < 0.01). The myocardial perfusion after PCI was closely correlated with the extent of heart function improvement 2 years after (chi(2) = 50.58, P < 0.01). CONCLUSION: TMP grading combined with sumSTR helps predict the 2-year outcome and heart function in the patients with AMI after emergency PCI.

Adult↗
PubMed2005

[Relationship between impulse noise and continuous noise inducing hearing loss by dosimeter measurement in working populations].

OBJECTIVE: To compare the dose-response relationship differences between impulse noise exposure workers and continuous noise exposure workers in prevalence of noise inducing hearing loss using dosimeter measurement. METHODS: Thirty-two mechanical workers in a workshop were selected as impulse noise group and 163 textile workers in a textile factory as continuous noise group. SH-126 dosimeter was used to measure A weighted equal sound level of eight hours (L(Aeq.8 h)) during full working duration with equal energy rule for the selected workers. The cumulative noise exposure (CNE) was calculated by L(Aeq.8 h) and noise working years with equal energy rule for each worker. Hearing thresholds were measured by audiometer by routine method and adjusted by age and gender with GBZ49 - 2002. Hearing loss was diagnosed by GBZ49 - 2002 for each worker. RESULTS: CNE of impulse noise group [(103.2 +/- 4.2) dB (A) .year] was found lower than the continuous noise group [(110.6 +/- 6.0) dB (A) .year] by significance, P < 0.05. The hearing loss prevalence of impulse noise group (68.8%) was similar as continuous noise group (65%) without significance, P > 0.05. Strata analysis showed the hearing loss prevalence in 100 - 104 dB (A) .year and 105 - 109 dB (A) .year of impulse noise group was double than that of continuous noise group (76.9%, 90.9% vs 30.4%, 50.0%), P < 0.05. The chi-square test showed a relationship between CNE and hearing loss prevalence that was in high significance (P < 0.01) in both impulse noise group and continuous noise group. Logistic regression model showed the dose-response relationship curve of impulse noise group was left shift and sharp slope. CONCLUSION: The damage of impulse noise on hearing loss was much more than that of continuous noise according to equal energy rule of dosimeter data.

Adult↗
PubMed2005

[Multi-institutional randomized controlled clinical trial on China made 4-demethoxydaunokrubicin (IDA) in the treatment of acute leukemia].

OBJECTIVE: To evaluate the efficacy and safety of IDA (Haizheng Parmacy, China) in the treatment of acute leukemia. METHODS: A multi-institutional single-blind randomized controlled clinical trial was carried out. A total of 155 newly diagnosed patients with AML and ALL were enrolled. The patients were randomly divided into two groups, one was given IDA (n = 77) and the other given zevodas (Pharnacia & Upjohn, n = 78) for comparison. RESULTS: All the patients enrolled in this trial were eligible for assessment of side effects, and 129 patients for evaluation of overall response rate. In patients treated with IDA vs zevodas, the overall response rate (OR) was 78.1% vs 76.9%, CR was 68.8% vs 67.7%; in AML patients, OR was 82.4% vs 71.8%, and CR was 76.5% vs 64.1%; in ALL patients, OR was 80.0% vs 81.8%, and CR was 68.0% vs 68.2%. There was no sitatistically significant difference in hematologic and non-hematologic toxicities between the two groups. CONCLUSION: The efficacy of IDA in the treatment of acute leukemia is comparable to that of zevodas. Both have similar toxic side effects.

Adolescent↗
PubMed2004

[The relationship between serum calcitonin gene-related peptide, sex hormone, homocysteine and coronary artery disease in postmenopausal women].

OBJECTIVE: To investigate the relationship between serum calcitonin gene-related peptide (CGRP), homocysteine (Hcy), sex hormone, and coronary heart disease (CHD) in postmenopausal women. METHODS: In a cross-sectional study, serum CGRP, estradiol (E(2)), progesterone (P) and Hcy levels of 144 postmenopausal women undergoing diagnostic CHD (75 with CHD and 69 without CHD) and 66 healthy young women were measured. RESULTS: The occurrence of CHD was correlated with high Hcy level and low CGRP level. The mean serum CGRP level was significantly lower in CHD postmenopausal women than in without CHD ones [(103.6 +/- 59.8) ng/L vs (164.6 +/- 50.7) ng/L, P < 0.01]. The mean serum E(2) level was significantly lower in CHD postmenopausal women than in without CHD ones [(67.9 +/- 24.4) pmol/L vs (91.7 +/- 23.0) pmol/L, P < 0.01]. The mean serum P level was significantly lower in CHD than in without CHD postmenopausal women [(0.89 +/- 0.46) nmol/L vs (1.11 +/- 0.45) nmol/L, P < 0.01]. The mean serum Hcy level was significantly higher in CHD than in without CHD postmenopausal women [(15.3 +/- 6.5) micromol/L vs (10.2 +/- 2.8) micromol/L, P < 0.01]. By multivariate logistic regression, the OR of high Hcy level > or = 1, P < 0.01, that means Hcy is an independent risk factor of CHD. The OR of CGRP, E(2) and P were all < or = 1, indicating that they were independent protective factor. CONCLUSIONS: Hcy is an independent risk factor of CHD. CGRP, E(2) and P are independent protective factors of CHD. There was no relationship between Hcy, CGRP and E(2) and P.

Adult↗
PubMed2003

[The value of autofluorescence spectrum analysis of gastric juice in diagnosing gastric carcinoma: a preliminary result].

OBJECTIVE: To reveal the difference of autofluorescence spectrums of gastric juice derived from malignancy and benignancy for screening and diagnosis of gastric carcinoma. METHOD: Gastric juice from 202 patients with different gastric diseases were collected, then detected their autofluorescence spectrums (the excitation wavelength is 288 nm, whereas the range of emission wavelength is 300 - 800 nm) after diluted by 1:10. The diagnostic model for gastric cancer was made by Classification and Regression Trees V2.0 software. RESULTS: There were three peaks (the emission wavelength were 320 - 360 nm, 576 nm and 670 - 690 nm respectively) in the autofluorescence spectrums of all patients, though the intensity of the first peak (with the emission wavelength of 320 - 360 nm) were enhanced distinctively in malignance than those in benignancy. The diagnostic model's sensitivity and specificity of prior probability were 91.4% and 83.2% respectively, whereas the sensitivity and specificity of posterior probability were 85.7% and 82.6%. CONCLUSION: Detection of autofluorescence spectrum of gastric juice has great prospect in the diagnosis and screening gastric carcinoma.

Adult↗