[Network construction on universal newborn hearing screening].
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China↗
Biomedical subjects
Yi-sheng Qi
Publications and source records attributed to Yi-sheng Qi.
[Flash visual evoked potentials on newborns and infants].
OBJECTIVE: To explore the feasibility of applying flash visual evoked potentials (FVEPs) for visual function test newborns and infants and bring out the consultable laboratory values of FVEPs. The technology of FVEP could be used as diagnostic tests for those who failed the screening and the infants who were cared for in the NICU. METHODS: 41 normal neonates (<or= 4 days) and 18 normal infants (<or= 5 months) were tested with FVEP by Nicolet Viking-IV model evoked potentials apparatus. RESULTS: Get the normal reference range of FVEPs latency in both groups and the consulting value of the difference between the left and right eyes. It has been observed from the paper that the latency of FVEPs has the tendency to shorten with the age increasing. It also shows that there are extreme significant changes of FVEPs (P < 0.05) by different frequency of stimulating light. CONCLUSION: The latency of FVEPs P1 is steady and could be applied to newborns-infants visual function test. While, the references of FVEPs according to different age group should be taken into account when we using this measure in clinic.
Age Factors↗
[The exploratory study of auto-auditory brainstem response in the high-risk infants on hearing screening].
OBJECTIVE: To compare the pass rate of auto-auditory brainstem response (AABR) in infants complicated with different high-risk factors. METHODS: 245 infants (488 ears) with different high-risk factors, including premature, low-weight, hyperbilirubinemia, asphyxiation and pulmonary diseases, were tested by transiently evoked otoacoustic emission (TEOAE) and AABR at the same time. RESULTS: The pass rate of AABR and that of TEOAE were different for the infants with different high-risk factors. The number that passed TEOAE test and referred to AABR test: premature 15 ears, low-weight 3 ears, for hyperbilirubinemia 1 ears, for asphyxiation 5 ears, and for pulmonary diseases 35ears. The pass rate of AABR was reduced evidently when infants had pulmonary diseases and the complicated high-risk factors (chi(2) = 35.723, P < 0.01). Different high-risk factors produced different pass rates of AABR (chi(2) = 40.556, P < 0.01). CONCLUSION: High-risk factors effect the auditory function. The pass rate of AABR is reduced evidently when an infant has both pulmonary diseases and the complicated high-risk factors. We should pay attention to these infants in universal newborn hearing screening.
Evoked Potentials, Auditory, Brain Stem↗
GJB2 gene mutations in newborns with non-syndromic hearing impairment in Northern China.
Mutations in GJB2 account for the majority of recessive forms of prelingual hearing loss. However, in most previous studies it was not possible to distinguish between congenital (present at birth) and non-congenital prelingual hearing loss. In the present study, the frequency of GJB2 alleles in 20 newborns with bilateral severe-to-profound non-syndromic hearing impairment (NSHI) who were found at birth through newborn hearing screening and clinical examination is reported. PCR was used to amplify the coding region of GJB2 gene followed by sequencing analyses. Fifty volunteers with normal hearing were included as controls. Results showed that three cases were 235delC/235delC homozygotes; one was 235delC/605ins46 compound heterozygotes, 605ins46 mutation was a novel mutation reported in the Chinese population; another was 235delC/299-300delAT compound heterozygotes. 25% (5/20) of the deafness in newborns studied was caused by GJB2 gene mutations. The frequency of 235delC allele carrier in patients and in control group was 22.5% and 1%, respectively. One case was identified as being a 235delC heterozygote without other mutations detected. Besides, multiple polymorphisms such as V27I, V37I, E114G, T123N were also detected. In conclusion, GJB2 analysis is an important test that identifies a major cause of newborns with bilateral severe-to-profound NSHI screened by universal newborn hearing screening in Northern China. The most common pathologic mutation of GJB2 in studied cases was 235delC. Molecular analysis and genetic counseling will be extremely important for congenital deafness present at birth.
Case-Control Studies↗
[Diagnosis and following-up and analysis of pathogenesis for congenital hearing loss].
OBJECTIVE: To investigate the incidence and the relevant high-risk factors of congenital hearing loss for infants from well-baby nursery and newborn intensive care unit. To explore the scientific and feasible mode of early diagnosis, following-up and early intervention. METHODS: Two-stage universal newborn hearing screening ( UNHS ) were performed by using transient otoacoustic emission ( TEOAE ). Auditory brainstem responses ( ABRs) and 40 Hz auditory event related potentials (40 Hz-AERPs) was used as diagnostic tests for those failed re-screening at three-month old. Two kinds of infants who had abnormal ABRs or high-risk factors of hearing loss received following-up and routine audiological evaluation from 6 months to 3 years of age. Each infant with congenital hearing loss received personalized intervention. RESULTS: The incidence of congenital hearing loss among infants who received UNHS was 5.73 per thousand. The incidence of congenital hearing loss was 20.02 per thousand in NICU and 3.67 in WBN. CONCLUSIONS: Whether passed the UNHS or not , infants from NICU should receive ABR and 40 HzAERP tests. The following-up population includes infants with abnormal ABRs or high-risk factors of hearing loss. Following-up and early intervention should be personalized.
Early Diagnosis↗
[A preliminary study of synchronous evoked potential in newborn-infant auditory and visual function test].
OBJECTIVE: The purpose of this study is to bring out the consultable laboratory values of synchronous evoked potential in normal neonates and infants, investigate the characteristic of the electric response waveform, and explore its feasibility on applying to newborn auditory and visual function test as an electric physiology detection method. METHODS: It was applied to go on measuring 19 cases of mature normal neonate (< or =4 days) and 11 cases of infants (< or =5 months), also comparing with the study of ABRs, FVEPs independently. RESULTS: Get the electric response wave form results of synchronous electric evoked potential in both groups of newborn-infants, through comparing with the result of independent ABRs and FVEPs, the monitoring result demonstrated that there were an extreme significant changes of the corresponding parameters (wave I, III, V latency) (P<0.01), and there were no significant changes of I-III, III-V interwave latency (P>0.05); it also shows that ABRs impact on FVEPs in N2 wave latency of newborn group and P1 wave latency of infant group (P<0.01). CONCLUSION: Auditory and vision pathway may be had communicated information by the neuron in the center. The technology of the auditory and visual synchronous evoked potential brings out the whole new electric physiology detection tools, it will definitely offer powerful technical support in step for newborn-infant auditory and visual function test.
Evoked Potentials, Auditory, Brain Stem↗
[A study on the risk indicators of newborn hearing loss].
OBJECTIVE: To explore the risk indicators of newborn hearing loss. METHODS: Statistic description was used to analyze the basic characteristics of 41 hearing loss infants screened from 8,262 newborns; one way analysis was used by 1:2 matched case control study to analyze the risk indicators of newborns with hearing loss; chi-square test and multivariate condition Logistic stepwise regression mode were also used to find risk the indicators. RESULTS: By one way analysis, there were 3 high risk indicators associated with newborn hearing loss: family history of hearing loss, craniofacial anomalies, and NICU care history. By analysis of multivariate condition Logistic stepwise regression mode, family history of hearing loss (OR=16.945, 95% CI 1.21-237.369) and craniofacial anomalies (OR=6.703, 95% CI 0.61-73.85) were 2 independent risk factors of newborn hearing loss. CONCLUSION: Appropriate intervention measure should be done to reduce the high risk indicators that cause newborn hearing loss.
Case-Control Studies↗
[Hearing screening of 10,501 newborns].
OBJECTIVE: To investigate the results of hearing screening in newborns so as to explore the appropriate clinical strategy of hearing screening among newborns. METHODS: Transiently evoked otoacoustic emission (TEOAE) was used to examine the hearing of 10,501 newborns 2 - 4 days after birth. Those who failed the initial screening underwent secondary screening with TEOAE. Acoustic brain-stem response (ABR) and 40 Hz AERP were used to monitor the hearing of those who failed the secondary screening every 6 months since the age of 3 months to the age of 3 years. RESULTS: The false-positive rate was 14.92% in the initial screening, and was 0.26% after the 2-stage screening. 62 infants were diagnosed with hearing loss with a prevalence of congenital hearing loss (in one ear or two ears) of 5.90 per thousand and a prevalence of bilateral hearing loss of 2.76 per thousand. CONCLUSION: Hearing screening in the procedure with TEOAE, ABR and 40 Hz AERP helps identify infants with hearing loss as early as possible so as to conduct appropriate intervention.
China↗
[The direction of universal newborn hearing screening in China].
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China↗