[Gene expression profile changes in human multiple myeloma].
OBJECTIVE: To determine the difference in gene expression between human multiple myeloma (MM) and normal bone marrow. METHODS: cDNA chip was used to detect the mRNA of mononuclear cell from 10 untreated MM patients and 10 cases of normal bone marrow. RESULTS: Of the 2,048 genes, we found 566 different expression genes, of which the expression of 237 genes was higher and 329 lower in MM than in the normal bone marrow. CONCLUSION: Many genes may be involved in the pathogenesis of MM. cDNA chip technology is an effective tool in the study of tumor related genes.
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