Biomedical subjects

Yolanda Delgado

Publications and source records attributed to Yolanda Delgado.

5 recordsLinked to original sources

PubMed2006

Nodular herpes zoster with herpetic syringitis and no epidermal involvement in a patient with Burkitt lymphoma.

Herpes zoster (HZ) occurs with an increased incidence in immunosuppressed patients, in whom it frequently displays atypical clinical presentations. Herpetic syringitis, the involvement of the eccrine epithelium by herpes virus infection, is an infrequently described histologic pattern that has been rarely and almost exclusively reported in HIV-infected patients. We report the case of a woman with Burkitt lymphoma who developed 2 nodular, asymptomatic lesions while receiving treatment with chemotherapy and radiotherapy for her hematological disease. Histology showed viropathic changes in the epithelium of eccrine glands not in the epidermis. PCR was positive for varicella-zoster virus (VZV). Nodular herpes zoster seems to be an exceptional clinical presentation. We report another such case which is, as far as we know, the first report of herpetic syringitis with no concomitant epidermal involvement.

Adult↗

PubMed2005

[Cutaneous large B-cell lymphoma of the leg].

Large B-cell lymphoma of the leg (LBCLL) accounts for 2 % of primary cutaneous lymphomas, and the EORTC considers it to be of intermediate prognosis. It usually presents in elderly patients, and manifests clinically as erythematous nodules or tumors, often unilateral, on the lower third of the legs. On rare occasions, it presents with extracutaneous dissemination. We present the case of a 77-year-old male who consulted his physician because of an asymptomatic indurated erythematous papule which had appeared one month earlier on his left leg and had quickly and progressively increased in size. Concurrently, other similar lesions had been appearing on the thigh and back of the same leg. Histological analysis detected a large cell lymphoid infiltrate positive for CD20 and bcl-2 throughout the dermis. The extension study was normal. The patient was treated with an intravenous infusion of rituximab for four consecutive weeks, with full remission of the lesions.

Aged↗

PubMed2005

[Cutaneous marginal zone B-cell lymphoma treated with rituximab].

Marginal zone B-cell lymphoma (MZL) is probably the most frequent of the primary cutaneous B-cell lymphomas, which are entities with indolent behavior. Clinically, it appears in middle-aged patients as papules, nodules or erythematous plaques, solitary or multiple, on the trunk and proximal part of the limbs. The prognosis is excellent despite frequent cutaneous recurrences. We present the case of a 40-year-old male who, after having several recurrences of MZL over a ten-year period, was treated with rituximab for multiple skin lesions. The patient showed full remission after four weeks of treatment, and developed cytokine-release syndrome after the first infusion of the drug.

Adult↗

PubMed2005

[Focal epithelial hyperplasia].

Focal epithelial hyperplasia (FEH) is a benign proliferation of the oral mucosa with well defined clinical and histological characteristics. It has been associated with infection of the oral mucosa by types 13 and 32 of the human papillomavirus (HPV), and to a lesser extent, with other types. Its clinical course is variable, although it usually persists for months or years; cases with spontaneous resolution have been described, as have others with prolonged persistence. We present the case of an Ecuadorian boy whose visit was motivated by lesions in the oral mucosa consistent with a diagnosis of FEH, which were confirmed in the histological study, and in which HPV type 13 DNA was identified.

Child↗

PubMedDate not supplied

[Mycosis fungoides-type eruptions induced by carbamazepine].

Cutaneous pseudolymphomas are inflammatory diseases of the skin that simulate malignant lymphomas in their clinical and/or histological form. Those induced by drugs are infrequent and are characterized by their clinical and histological polymorphism. There is no consensus regarding the definition of these dermatoses, and they can be seen in different forms of presentation. There are two main groups of drug-induced pseudolymphomas: those that clinically and histologically simulate cutaneous lymphomas, and those known as hypersensitivity syndromes. Pseudolymphomas cannot be differentiated from true lymphomas through clinical, pathological or molecular findings. The definitive test for diagnosis is the resolution of the lesions after the medication involved is suspended. We present three cases of carbamazepine-induced cases of pseudolymphomas that histologically simulate mycosis fungoides, with different clinical presentations.

Adult↗