Biomedical subjects

Yong S Choe

Publications and source records attributed to Yong S Choe.

3 recordsLinked to original sources

PubMed2006

Effect of a viscous fiber-containing nutrition bar on satiety of patients with type 2 diabetes.

To assess the satiety-promoting effect of a novel viscous fiber-containing nutrition bar, overweight and obese adult subjects with type 2 diabetes (n=99) were randomized into a double blind, crossover study. They were fed a 300kcal lunch consisting of viscous fiber-containing nutrition bars (VF) or commercial nutrition control bars designed for people with diabetes (CH). VF resulted in a 27.1% increase in fullness (p<0.05), a 15.8% decrease in prospective consumption (p<0.001), and a 14.2% decrease in hunger (p<0.001) in the 120-240min post-lunch areas under the curve (AUC) compared to CH, but no differences were observed for nausea or thirst (p>0.05). Similar results were noted for 0-300min AUC values. VF were associated with greater frequencies and intensities of abdominal distention (p<0.001) and flatulence (p<0.001), and greater frequency of stools (p<0.001) compared to CH, but there were no differences in mean or maximum (loosest) stool consistency (p>0.05). Overall, these results suggest that VF could be a useful tool in weight management of type 2 diabetes.

Adolescent↗

PubMed2006

Effect of a viscous fiber bar on postprandial glycemia in subjects with type 2 diabetes.

OBJECTIVE: To compare the effect of an experimental viscous fiber (VF) crispy bar on the postprandial glucose, insulin, and C-peptide response in adult subjects with type 2 diabetes to two commercially available control crispy bars. DESIGN: The study was a randomized, double-blinded, three period, crossover study. SETTING: The study was conducted at two sites: Park Nicollet Institute, International Diabetes Center, Minneapolis, MN, and Radiant Research, Inc., Minneapolis, MN. SUBJECTS: A total of 60 adults with type 2 diabetes taking oral antihyperglycemic medication participated in the study. INTERVENTION: After an overnight fast, subjects consumed a test meal containing an equicaloric amount (300 kcal) of an experimental VF crispy bar or one of two commercially available crispy bars at each of three test visits, followed by a four hour meal tolerance test. Subjects also completed gastrointestinal (GI) response records for the 24 hours following each test visit. RESULTS: The VF crispy bars produced significantly lower glucose (p < 0.0001), insulin (p < 0.0001), and C-peptide (p < 0.0001) responses (as measured by positive area under the curve) in subjects with type 2 diabetes, as compared with the two commercially available bars. Intensity (p < 0.05) and frequency (p < 0.05) of flatulence were significantly higher with the VF bar as compared with the 2 commercial bars. While the VF bar produced significant subjective GI tolerance scoring values, the mean value was below 3 on a scale of 0 (no effect) to 10 (most severe effect) for all tested materials. CONCLUSIONS: The incorporation of VF into a crispy bar provided a means to improve blood glucose levels by reducing postprandial glucose, insulin, and C-peptide responses in subjects with type 2 diabetes. Though associated with some GI symptoms, VF may have application in improving the postprandial glycemic response in people with diabetes attempting intensive glucose control.

Area Under Curve↗

PubMed2003

Pullulan is a slowly digested carbohydrate in humans.

Pullulan is an extracellular polysaccharide excreted by the fungus Aureobasidium pullulans. To evaluate the glycemic and breath hydrogen responses and gastrointestinal tolerance to pullulan, nondiabetic healthy adult subjects (n = 28) were studied in a randomized, double-masked, crossover design. After an overnight fast, subjects consumed beverages containing 50 g of carbohydrate from either maltodextrin (control) or pullulan. Capillary blood glucose response was determined for 180 min postprandially. Breath hydrogen response was determined for 8 h postprandially. Compared with control, incremental peak blood glucose concentration was reduced (P < 0.01) when subjects consumed pullulan (4.24 +/- 0.35 vs. 1.97 +/- 0.10 mmol/L). In addition, pullulan reduced (P < 0.01) the positive incremental area under the glucose curve by 50%. When subjects consumed pullulan, the incremental blood glucose excursions were reduced (P < 0.01) at 15, 30, 45, 60 and 90 min, but were maintained above basal glucose concentrations at 150 and 180 min. At 180 min, the blood glucose concentration was higher (P < 0.05) when subjects consumed pullulan compared with control, supporting the hypothesis that pullulan is digested slowly. Breath hydrogen concentrations were increased (P < 0.01) at 3, 4, 5, 6, 7 and 8 h postprandially when subjects consumed pullulan. In the first 24-h postprandial period, the frequency and intensity of flatulence was higher (P < 0.05) after subjects consumed pullulan compared with control. In conclusion, pullulan attenuated the postprandial glycemic excursion compared with an equivalent maltodextrin challenge. Pullulan also increased breath hydrogen excretion and the incidence of gastrointestinal intolerance symptoms, indicating that a portion of pullulan was malabsorbed.

Adolescent↗