Yong-Ming Li | PubMed Health

PubMed2006

A new strategy for urinary sediment segmentation based on wavelet, morphology and combination method.

This paper presents a strategy for segmenting urinary sediment based on wavelet, morphology and combination method. Firstly, the wavelet transforms and morphology are used to get rid of the effect of the defocusing and get the subimages that include the particles. Then based on the characteristics of the subimages, edge detection and adaptive thresholding are employed adaptively. Finally, a simplified watershed algorithm for the overlapping particles is used. The experiment results show that the method can segment the defocusing urinary sediment images effectively and precisely.

Humans↗

PubMed2006

Aquaporins as potential drug targets.

The aquaporins (AQP) are a family of integral membrane proteins that selectively transport water and, in some cases, small neutral solutes such as glycerol and urea. Thirteen mammalian AQP have been molecularly identified and localized to various epithelial, endothelial and other tissues. Phenotype studies of transgenic mouse models of AQP knockout, mutation, and in some cases humans with AQP mutations have demonstrated essential roles for AQP in mammalian physiology and pathophysiology, including urinary concentrating function, exocrine glandular fluid secretion, brain edema formation, regulation of intracranial and intraocular pressure, skin hydration, fat metabolism, tumor angiogenesis and cell migration. These studies suggest that AQP may be potential drug targets for not only new diuretic reagents for various forms of pathological water retention, but also targets for novel therapy of brain edema, inflammatory disease, glaucoma, obesity, and cancer. However, potent AQP modulators for in vivo application remain to be discovered.

Animals↗