Biomedical subjects

Yoosoo Chang

Publications and source records attributed to Yoosoo Chang.

4 recordsLinked to original sources

PubMed2006

gamma-Glutamyltransferase as a predictor of chronic kidney disease in nonhypertensive and nondiabetic Korean men.

BACKGROUND: Little research has been done to examine whether gamma-glutamyltransferase (GGT) is prospectively associated with the development of chronic kidney disease (CKD). We performed a prospective study to examine the association between GGT and the risk for the development of CKD. METHODS: The study cohort included a total of 10 337 healthy males with normal baseline kidney functions and no proteinuria. Participants were workers in a semiconductor manufacturing company and its 13 affiliates. CKD was defined as either the presence of proteinuria or a glomerular filtration rate (GFR) of < 60 mL x min(-1) x (1.73(2))(-1). Cox proportional hazards models were used to calculate the adjusted hazard ratios in separate models for CKD. RESULTS: During a follow-up period of 25,774.4 person-years, 366 men developed CKD. After adjustments were made for age, baseline GFR, triglyceride, and HDL-C, the risk for CKD increased with an increasing quartile of serum GGT (p for trend <0.001). The top one fourth of serum GGT vs the bottom one fourth of relative risks for CKD was 1.90 (95% confidence interval, 1.37-2.63). These associations were also apparent in participants who consumed < or = 20 g/day of alcohol and those with normal weight, with values of alanine aminotransferase within reference intervals, or with C-reactive protein < 3.0 mg/L, and participants without metabolic syndrome. CONCLUSIONS: Our findings, which were obtained from a large work-site cohort and excluded individuals with diabetes and hypertension, indicated that serum GGT may be an early predictor for the development of CKD, independent of baseline confounding factors.

Adult↗

PubMed2006

The sequential changes in the fasting plasma glucose levels within normoglycemic range predict type 2 diabetes in healthy, young men.

AIMS: We assessed whether the increased sequential changes in the fasting plasma glucose level (FPG) that is still within the normoglycemic range could be a predictor for future diabetes. METHODS: A prospective cohort study was conducted with 5296 male employees, aged 31-44 years. A sequential change in the FPG level was defined as the first follow-up FPG level minus the baseline FPG level. The incident diabetes was assessed at annual examinations during the next 4.1 years. Cox proportional hazard analyses were performed. RESULTS: During the 21,575.5 person-years follow-up among the 5,296 subjects, a total of 156 incident cases of type 2 diabetes occurred (116 cases among the 4,975 normoglycemic subjects and 40 cases among the 321 subjects with impaired fasting glucose). An increase in the FPG level from the baseline to the first follow-up, although still within the normoglycemic range (FPG<100 mg/dl), significantly predicted future diabetes: the multivariate hazard ratios associated with the sequential changes in the FPG of <-3, -3 to 3, 4-6, 7-9, and >9 mg/dl were 0.75, 1.00 (reference), 2.28, 3.28, and 6.10, respectively (p for trend <0.001). CONCLUSIONS: The increase of the sequential changes in the FPG level that were within the normal glucose range was associated with a higher risk for developing diabetes. Thus, conducting assessment for the serial changes in the FPG level may help to identify the young, healthy, normoglycemic individuals at risk for type 2 diabetes.

Adult↗

PubMed2006

Should the lower limit of impaired fasting glucose be reduced from 110 mg/dL in Korea?

The aims of this study were to determine if impaired fasting glucose should be redefined as a fasting plasma glucose (FPG) of 100 to 125 mg/dL (5.6-6.9 mmol/L) in Korea. A prospective cohort study was undertaken involving 13189 male workers aged 30 to 59 years who did not have medication for diabetes, a history of any cancer, or a fasting glucose level of 126 mg/dL or higher at the initial examination between January 1999 to December 2000. Subjects were reexamined at periodic annual health examination over a 5-year period. The receiver operating characteristic curve for predicting the future onset of diabetes was derived by plotting the sensitivity against 1 - specificity for a baseline FPG of less than 126 mg/dL. The age- and body mass index-adjusted incidence density of type 2 diabetes mellitus was examined according to the percentile of the distribution for the baseline FPG. The baseline FPG for predicting the future onset of diabetes at a point on the receiver operating characteristic curve that was closest to the ideal 100% sensitivity and 100% specificity was 92 mg/dL. There was a threshold for the age- and body mass index-adjusted incidence density of diabetes in the group with FPG of 93 to 95 mg/dL, at a mean of 93.9 mg/dL. Lowering the lower limit of impaired fasting glucose to 100 mg/dL (5.6 mmol/L) would optimize its sensitivity and specificity for predicting the future onset of diabetes in Korea.

Adult↗

PubMed2005

Spectrum of insulin sensitivity in the Korean population.

The aims of the present study were to (1) examine the range of values for insulin sensitivity measures such as fasting serum insulin, homeostasis model assessment (HOMA), and quantitative insulin sensitivity check index (QUICKI) and (2) to identify cutoffs for indirect indexes of insulin sensitivity such as insulin, HOMA, and QUICKI that confer increased risk of metabolic syndrome in a large sample of Korean adults. The total number of study subjects involved was 83186. All of them presented for a routine health status checkup at the Kangbuk Samsung Hospital between January 2003 and December 2004, and none of them was currently taking medication for hypertension, diabetes, or dyslipidemia. We used 3 measures of insulin sensitivity: the fasting serum insulin, the HOMA, and the QUICKI. The age- and sex-adjusted prevalence of metabolic syndrome was examined by tenths of the distribution of each index of insulin. The fasting serum insulin, HOMA, and QUICKI were compared by using receiver operating characteristic curves. The fasting serum insulin ranged from 1.71 to 70.40 microU/mL, with the 25th percentile = 5.97, the median = 7.69, and the 75th percentile = 9.82. The HOMA ranged from 0.34 to 17.72, with the 25th percentile = 1.33, the median = 1.74, and the 75th percentile = 2.27. The QUICKI ranged from 0.112 to 0.202, with the 25th percentile = 0.146, the median = 0.152, and the 75th percentile = 0.158. The insulin, HOMA, and QUICKI values at the point on the receiver operating characteristic curve closest to the ideal of 100% sensitivity and 100% specificity for detecting the presence of metabolic syndrome were 9.7 microU/mL, 2.43, and 0.145, respectively. In conclusion, these findings describe the spectrum of insulin sensitivity in Korean adults. This study is the first attempt to determine cutoff values for indirect indexes of insulin sensitivity such as insulin, HOMA, and QUICKI that confer an increased risk of metabolic syndrome. These findings may be useful for evaluating insulin resistance, particularly in epidemiological studies.

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