Biomedical subjects

Yoshie Kimura

Publications and source records attributed to Yoshie Kimura.

4 recordsLinked to original sources

PubMed2006

Reducing the dose of antipsychotic agents ameliorates visual hypersensitivity attack: an ideal treatment option in terms of the adverse effect.

There are sporadic reports of antipsychotic-induced visual hypersensitivity attack (VHA). VHA is characterized by hypersensitivity of perception mainly in the visual modality and sometimes accompanied by an oculogyric crisis. However, some researchers regard VHA as a schizophrenia symptom. To determine whether VHA is an adverse effect of antipsychotic agents, we examined the effect of dose reduction on VHA. This was an open-label 36-week study. We randomized 34 patients with VHA to a reduced-dose group and a fixed-dose group. Primary outcome measures were the frequency and duration of VHA, assessed with patients' self-reports, and the Clinical Global Impressions (CGI). Assessment also included the Drug-induced Extrapyramidal Symptoms Scale for extrapyramidal symptoms, the Positive and Negative Syndrome Scale (PANSS) for schizophrenia, and the CGI for other diagnoses. Data were collected from August 2000 to April 2005 at 4 psychiatric hospitals in Tokyo.VHA diminished in 16 patients (94.1%) in the reduced-dose group in the CGI score, the frequency (number of episodes per week), and the duration of the episodes (from 4.06 to 1.77, P < 0.001; from 2.59 to 0.82, P = 0.001; and from 1.92 to 0.66 hours, P = 0.007, respectively), but there were no changes in the fixed-dose group. There were no changes in the underlying illness as measured by the PANSS in both groups. Reducing the dose of antipsychotic agents ameliorates VHA and represents the ideal treatment option for patients with VHA.

Adolescent↗

PubMed2005

Relationships between temperament dimensions in personality and unconscious emotional responses.

BACKGROUND: In addition to character dimensions, personality includes temperament dimensions, defined as individual differences in implicit associative learning responses to environmental stimuli processed by unconscious memories. We examined whether temperament dimensions were associated with patterns of unconscious emotional responses of an autonomic nature. METHODS: From 70 healthy men, high and low novelty-seeking (NS) groups and high and low harm-avoidance (HA) groups were selected using scores on the Tridimensional Personality Questionnaire measuring temperament dimensions. Emotionally negative, neutral, and positive visual stimuli were presented subliminally using backward masking, and skin conductance responses (SCRs) were measured as an autonomic index of emotional responses. Skin conductance responses to the three emotional stimulus conditions were compared between groups. RESULTS: Skin conductance responses in the high NS group were significantly greater than in the low NS group when positive or negative emotional stimuli were presented but not neutral stimuli. Skin conductance responses in the high HA group were significantly greater than in the low HA group for stimuli of all three valences. CONCLUSIONS: Autonomic response patterns to unconscious emotional perception differed between NS and HA, suggesting that different dimensions of temperament may be associated with different patterns of unconscious emotional responses. Novelty seeking and HA may be associated with specificity and susceptibility of preattentive emotional perception, respectively.

Adult↗

PubMed2005

[Anesthetic management for Cesarean section in a patient with left ventricular noncompaction].

Left ventricular noncompaction (LVNC) is a rare disease characterized by heart failure, arrhythmia, and embolic events. We report anesthetic management of a pregnant woman with LVNC. At 24 weeks gestation of the first pregnancy, the patient was scheduled for Cesarean section. Preoperatively the patient had symptomatic heart failure, and was anesthetized with propofol and fentanyl aiming at stable intraoperative hemodynamics. About 2 years later, the patient also underwent cesarean section under spinal anesthesia at 34 weeks gestation of the second pregnancy, because her cardiac function was almost normal and she was not receiving anticoagulant therapy. Both perioperative courses were uneventful. Careful preoperative assessment and close anesthetic planning are necessary.

Adult↗

PubMed2004

Interhemispheric difference in emotional response without awareness.

To investigate interhemispheric differences concerning unconscious human emotional responses processed, we measured human skin conductance responses (SCRs) to masked (unseen) emotional stimuli presented to left or right visual fields. Backward masking was used to preclude conscious processing of emotional stimuli. Masked negative or neutral emotional pictures from the International Affective Picture System (IAPS) were presented to 11 right-handed male volunteers. Mean SCR for negative emotional stimuli presented to the left visual field was significantly greater than mean SCRs for negative emotional stimuli to the right visual field and for neutral stimuli to the left or right visual fields. Thus, the right rather than the left hemisphere appears to respond to preattentive negative emotional stimuli.

Adult↗