Biomedical subjects

Yoshihiro Miura

Publications and source records attributed to Yoshihiro Miura.

3 recordsLinked to original sources

PubMed2006

Atrophic dermatofibrosarcoma protuberans with diffuse eosinophilic infiltrate.

Atrophic dermatofibrosarcoma protuberans (atrophic DFSP) is a variant of dermatofibrosarcoma protuberans (DFSP), and is clinically characterized by depressed lesions. We report a patient with a typical atrophic DFSP lesion with marked eosinophilic infiltration. The patient was a 55-year-old woman with a dark-red, depressed lesion in the epigastric region. Histopathological examination of the lesion showed proliferation of fibroblast-like cells in a storiform pattern in the dermis and subcutaneous tissue. Immunohistochemical staining of tumor cells was positive for CD34. The lesion was histopathologically typical of DFSP, but no elevated lesion was clinically observed. Thus, a diagnosis of atrophic DFSP was made. Moreover, this tumor tissue exhibited marked eosinophilic infiltration. To our knowledge, they are no reports of eosinophilic infiltration in DFSP tissue. Therefore, this seems to be an extremely rare case of DFSP.

Dermatofibrosarcoma↗

PubMed2005

Epithelioid cell histiocytoma with underlying artery damage.

Although epithelioid cell histiocytoma is considered a variant of fibrous histiocytoma (dermatofibroma), the histogenesis of this condition remains controversial. A recent investigation suggested the possibility that epithelioid cell histiocytoma is an angioformative fibrous histiocytoma. We report a case of epithelioid cell histiocytoma underlying a damaged artery. This epithelioid cell histiocytoma with a central area of hemorrhage was associated with a medium-sized artery in the reticular dermis running vertically up to the lesion. Both the artery in the reticular dermis and its centrally branched artery in the subcutaneous tissue showed mural injury and intraluminal epithelioid endothelial proliferation. Immunohistochemically, the labeling rate for each of the antibodies studied in the epithlioid cells was as follows: 40% for Factor XIIIa, 5% for CD34, 20% for factor VIII-related antigen, and 10% for alpha-smooth muscle cell actin. This case may support the view that epithelioid cell histiocytoma is a vascular and angioformative fibrous histiocytoma.

Biopsy, Needle↗

PubMedDate not supplied

Giant polypoid basal cell carcinoma with features of fibroepithelioma of Pinkus and extensive cornification.

We report on a case of a 61-year-old woman with a giant polypoid BCC, measuring 7.1 x 5.0 x 2.2 cm, on the genital region (the pubic area). The histopathological features of this BCC interestingly showed fibroepithelioma of Pinkus with cornification, and merging with nodular BCC with extensive cornification (so-called keratotic BCC). The giant BCC with features of fibroepithelioma of Pinkus is exceedingly rare.

Basal Cell Carcinoma↗