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Biomedical subjects

Yossi Rimar

Publications and source records attributed to Yossi Rimar.

9 recordsLinked to original sources

Human herpesvirus-8: beyond Kaposi's .

Today, more than 10 years and 2000 articles since human herpesvirus 8 was first described by Chang et al., novel insights into the transmission and molecular biology of HHV-8 have unveiled a new spectrum of diseases attributed to the virus. The association of HHV-8 with proliferative disorders--including Kaposi's sarcoma, multicentric Castleman disease and primary effusion lymphoma--is well established. Other aspects of HHV-8 infection are currently the subject of accelerated research. Primary HHV-8 infection may manifest as a mononucleosis-like syndrome in the immunocompetent host, or in various forms in the immunocompromised host. The association of HHV-8 with primary pulmonary hypertension was observed by Cool et al. in 2003, but six clinical trials evaluating the role of HHV-8 in pulmonary hypertension have not been able to replicate this intriguing observation. It has been speculated that HHV-8 may secondarily infect proliferating endothelium in patients with pulmonary hypertension. HHV-8 epidemiology, modes of transmission, new spectrum of disease and treatment are presented and discussed.

Adult↗

[The history of the speckled monster].

It demolished 3 empires, killed princess and peasants indifferently, blinded its victims and scarred them for life, changed the outcome of military conflicts and eventually induced the discovery of the vaccination technique. Although conquered in the late seventies of the 20th century, the spirit of "the speckled monster"--smallpox as it was called due to its coetaneous manifestation and high death rate, still roam the earth as a bioterrorist threat. From China to Turkey, from England to the U.S.A., smallpox plague history traverses nations and physicians. This paper discusses the history of the disease and brings forward some of the less famous characters who contributed to the eradication of smallpox.

History, 18th Century↗

[Mary Mallon, Mr. N and Mr. Koch as well].

Societal attitudes towards disease carriers is not ideal and is often associated with prejudice. This phenomenon was well documented in the era of Robert Koch who was one of the leading scientists claiming that disease carriers might cause epidemics. The authors recount the tale of two salmonella typhi carriers, Mr. N and Mary Mallon, who were responsible for transmitting typhoid. These cases highlight the problematic nature of the subject and the need for an enhanced medical and legal-social treatment model aimed at improving the status of disease carriers and limiting their impact on society.

Carrier State↗

[The history of blood transfusions].

Numerous lives are being saved each passing day via blood transfusions. Merely a century ago, blood transfusions were considered dangerous. Yet, for physicians of the 21st century, the absence of blood transfusions is unimaginable. The history of blood transfusion travels through states, religions and discoverers--from a pope to a French charlatan and from an English doctor to an Austrian converted Jewish physician. This article attempts to shade light upon some of the central events concerning the history of blood transfusions.

Blood Transfusion↗

[Everything you wanted to know about diagnosis but never dared to ask].

Making the correct diagnosis is essential for any physician. On occasions, this thorny task may demand profound knowledge combined with analytical skills. During the ages, logical devices were developed to help the bewildered physician accomplishing this task. This article will review some of the more celebrated devices. "Perfection is achieved, not when you have nothing more to add, but when you have nothing more to take away" Antoine de Saint-Exupery (Wind, Sand and Stars)

Diagnosis↗

[What causes English sweats?].

English sweating disease also known as Sudor Anglicus is one of the least familiar epidemics of the Middle Ages, striking England 5 times during the 15th and 16th centuries before fading. This article will discuss the knowledge available to us about this fascinating epidemic, its characteristics and causes.

England↗

[Elementary, my dear Watson].

Sherlock Holmes, the greatest detective who never lived, draws a great amount of influence from the medical world. Arthur Conan Doyle, Sherlock Holmes creator and the author of his many adventures, was a physician, before devoting himself to writing. Doyle was fascinated with the incredible abilities of his legendary teacher, Dr. Joseph Bell, to draw conclusions based on apparently minor unimportant details. At a later stage, Doyle admitted that Sherlock Holmes' character was based upon Joseph Bell way of practicing medicine. Sherlock Holmes' adventures are paved with medical descriptions of various illnesses. This article reviews the connection between the author, the detective and the medical world.

England↗

[Life and death at the tip of the tongue--the power of words].

The names of various common diseases have an etymological source derived from the names and revelations of scholars, scientists, physicians and famous figures from the near and distant past. This article unveils some of the mystery, the tales and the etymology behind those diseases.

Disease↗